| development of a dna-mva/hiva vaccine for kenya. | without going into the details of the devastation that human immunodeficiency virus (hiv) infection causes especially in the developing world, the best hope for changing the course of this epidemic is development of a safe, effective, accessible prophylactic hiv vaccine. while the inaccessibility of potentially neutralising epitopes on primary hiv isolates has hampered the development of envelope-based vaccines, there is a number of new potent technologies capable of inducing high levels of circ ... | 2002 | 11983261 |
| drug evaluation: dna/mva prime-boost hiv vaccine. | oxford university and nairobi university are jointly developing a hiva.dna/modified vaccinia ankara (mva) prime-boost vaccine for the potential prevention of infection with hiv subtype a. the vaccination strategy consists of priming with a dna vaccine made from hiv-1 clade a gag p24/p17 consensus sequence (pthr.hiva) then boosting with a mva virus expressing hiva (mva.hiva). phase ii clinical trials of the vaccine are underway in kenya and the uk. | 2007 | 17328232 |
| a dna/mva-based candidate human immunodeficiency virus vaccine for kenya induces multi-specific t cell responses in rhesus macaques. | the minimum requirement for candidate human immunodeficiency virus (hiv) vaccines to enter clinical evaluation in humans should be their demonstrable immunogenicity in non-human primates: induction of antibodies neutralizing primary hiv isolates or elicitation of broad t cell-mediated immune responses. here, we showed in rhesus macaques that the very same vaccines that had entered clinical trials in oxford and nairobi, plasmid pthr.hiva dna and recombinant modified vaccinia virus ankara mva.hiva ... | 2002 | 11752703 |
| pedvacc 002: a phase i/ii randomized clinical trial of mva.hiva vaccine administered to infants born to human immunodeficiency virus type 1-positive mothers in nairobi. | a safe, effective vaccine for breastfeeding infants born to hiv-1-positive mothers could complement antiretroviral therapy (art) for prevention of mother-to-child transmission of hiv-1. to date, only a few hiv-1 vaccine candidates have been tested in infants. | 2014 | 25173484 |