| application of a new bioassay technique using goldfish for assessment of water toxicity. | there are a variety of chemicals in aquatic environment, so it is important to assess the toxicity. the biomarkers such as induction of dna damage, micronuclei, vitellogenin, and hepatic p450 in fish are known to be effective for monitoring genotoxic and/or estrogenic chemicals. however, there is little study to use these biomarkers in same fish. goldfish (carassius auratus) is widely used and is suitable in size to collect blood or organs. in this study, validity of multiple-biomarkers in goldf ... | 2008 | 18344213 |
| isolation and identification of non-chlorinated phenylbenzotriazole (non-clpbta)-type mutagens in the ho river in shizuoka prefecture, japan. | we previously identified 2-[2-(acetylamino)-4-amino-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2h-benzotriazole (pbta) congeners as major mutagens in water concentrates from several rivers that flow in three different areas, i.e. kyoto, aichi, and fukui prefectures, in japan. in synthesis studies, these pbtas were shown to be formed from corresponding dinitrophenylazo dyes via non-chlorinated derivatives (non-clpbtas). however, only non-clpbta-1, i.e. 2-[2-(acetylamino)-4-[bis(2-methoxyethyl)amin ... | 2006 | 16962368 |