| azole-resistant aspergillus fumigatus containing a 34-bp tandem repeat in cyp51a promoter is isolated from the environment in japan. | azole-resistant strains of aspergillus fumigatus containing a tandem repeat in the cyp51a promoter and amino acid substitution(s) have been isolated in the environment worldwide; however, this type of resistant strain had never been isolated from the environment in japan. our previous study indicated that an azole-resistant a. fumigatus strain okh50 containing a 34-bp tandem repeat in cyp51a promoter with l98h substitution in cyp51a was isolated from a patient in obihiro of hokkaido, japan. in t ... | 2017 | 28566661 |
| azole susceptibility in clinical and environmental isolates of aspergillus fumigatus from eastern hokkaido, japan. | azole antifungals are used not only clinically for fungal infections but also used as agricultural fungicides. recently, azole-resistant aspergillus fumigatus containing a tandem repeat in the promoter region of cyp51a combined with amino acid substitution(s) appears in the environment in eurasia, especially in several european countries. although azole fungicides have been used in japan, especially in hokkaido, surveillance and characterization of a. fumigatus in hokkaido have not been reported ... | 2016 | 27050399 |