| prevalence of serum neutralizing antibodies to adenovirus type 5 (ad5) and 41 (ad41) in children is associated with age and sanitary conditions. | neutralizing antibody (nab) can dampen the immunogenicity of adenovirus (ad) vector-based vaccine. vector systems based on human adenovirus type 41 (ad41) have been constructed and used to develop recombinant vaccines. here, we attempted to study the seroprevalence of nabs to ad5 and ad41 among children and adults in qinghai province, china. the positive rates (titerā©¾40) of ad5 and ad41 nab in adults from xining city were 75.7% and 94.7%, respectively. the moderate/high-positive rates (titerā©¾160 ... | 2016 | 27682509 |