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neutralizing antibodies against adenovirus type 2 in normal and hiv-1-infected subjects: implications for use of ad2 vectors in vaccines.pre-existing neutralizing antibodies (nabs) directed against vaccine vectors have attracted considerable research attention. therefore, our aim was to establish a high-throughput economical neutralization assay to investigate the epidemiology of adenovirus type 2 (ad2)-specific immunity in china and developed countries, including in a chinese human immunodeficiency virus (hiv)-1-infected population, and to guide the application of ad2-vectored vaccines. we established a fluorospot-based anti-ad2 ...201728301274
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