| response surface methodology optimization of fermentation conditions for rapid and efficient accumulation of macrolactin a by marine bacillus amyloliquefaciens esb-2. | in the present work, an antibiotic-producing marine bacterium was isolated from a seawater sample collected from yuhuan, zhejiang, china, identified and named as bacillus amyloliquefaciens esb-2 on the basis of phenotypic characteristics and 16s rrna gene sequencing. response surface methodology was applied to optimize the fermentation conditions for rapid and efficient accumulation of macrolactin a, a pharmacologically important marine antibiotic. eight fermentation conditions were examined for ... | 2012 | 23275049 |