| antigenic diversity among onchocerca volvulus in nigeria, and immunological differences between onchocerciasis in the savanna and forest of cameroon. | onchocerciasis is a remarkably chronic infection and, in west africa, there are distinct clinical and pathological differences between the disease in the savanna and in the forest. experiments were carried out to see whether antigenic diversity among ochocerca volvulus worms might contribute to these features. extracts of adult worms and or microfilariae were analysed by disc electrophoresis on polyacrylamide gels and showed a remarkable diversity of protein patterns but no consistent savanna/fo ... | 1976 | 949872 |
| onchocerca-simulium complexes. i. transmission of forest and sudan-savanna strains of onchocerca volvulus, from cameroon, by simulium damnosum from various west african bioclimatic zones. | | 1966 | 5971132 |
| population biology of human onchocerciasis. | human onchocerciasis (river blindness) is the filarial infection caused by onchocerca volvulus and transmitted among people through the bites of the simulium vector. some 86 million people around the world are at risk of acquiring the nematode, with 18 million people infected and 600,000 visually impaired, half of them partially or totally blind. 99% of cases occur in tropical africa; scattered foci exist in latin america. until recently control programmes, in operation since 1975, have consiste ... | 1999 | 10365406 |
| studies on the macrofilarial population of onchocerca volvulus in hyper-endemic villages of the central province of cameroon. | the population structure of onchocerca volvulus macrofilariae was studied in villages of central cameroon where onchocerciasis is hyper-endemic. one nodule selected at random was removed from each of 576 adult males, and examined by histology. the numbers of male and female worms/nodule, and the status of the female worms (fecund, non-fecund, or dead) were recorded. the observations were analysed to evaluate whether the mean numbers of worms of each category varied in relation to the patient's a ... | 2001 | 11454247 |
| experimental studies on the transmission of onchocerca volvulus by its vector in the sanaga valley (cameroon): simulium squamosum b. intake of microfilariae and their migration to the haemocoel of the vector. | as large-scale ivermectin distribution is becoming the mainstay of onchocerciasis control in africa, the issue of its impact on local transmission is increasing in importance. the vector competence of simulium squamosum b in the severe focus of the sanaga valley, cameroon, was therefore investigated, by feeding 1320 flies on 14 carriers of onchocerca volvulus microfilariae (mff). the results enabled the relationships between skin microfilarial load, microfilarial intake by the flies, the proport ... | 2003 | 12831524 |
| genetic polymorphism of the beta-tubulin gene of onchocerca volvulus in ivermectin naïve patients from cameroon, and its relationship with fertility of the worms. | observations of low response of patients infected with onchocerca volvulus to ivermectin suggest that the parasite may be under a selection process toward potential resistance. to limit the extension of this phenomenon, it is crucial to characterize the genes of o. volvulus that are involved. for this, o. volvulus adult worms collected before the introduction of ivermectin in an onchocerciasis endemic area of central cameroon were genotyped for beta-tubulin. to derive a baseline to investigate t ... | 2006 | 16197589 |
| onchocerciasis-associated limb swelling in a traveler returning from cameroon. | travelers to west central africa are at risk for infection with onchocerca volvulus. we describe the case of an adventurous traveler who became infected with o volvulus after a 10-day stay in rural cameroon. two years after his return, he was diagnosed with a 3-month history of limb swelling with pruritus and fixed edema of the right arm. he was successfully treated by a single dose of ivermectin, with an additional treatment with doxycycline. the patient was followed-up during 1 year after ther ... | 2006 | 16412109 |
| factors associated with ivermectin non-compliance and its potential role in sustaining onchocerca volvulus transmission in the west region of cameroon. | community directed treatment with ivermectin is the cornerstone of current efforts to eliminate onchocerciasis. however recent studies suggest there are foci where long-term annual distribution of the drug alone has failed to ensure elimination thresholds are reached. it is important to achieve high levels of compliance in order to obtain elimination targets. an epidemiological and entomological evaluation conducted in the western region of cameroon in 2011 revealed that two health districts rem ... | 2016 | 27529622 |
| ongoing transmission of onchocerca volvulus after 25 years of annual ivermectin mass treatments in the vina du nord river valley, in north cameroon. | recent reports of transmission interruption of onchocerca volvulus, the causing agent of river blindness, in former endemic foci in the americas, and more recently in west and east africa, raise the question whether elimination of this debilitating disease is underway after long-term treatment of the population at risk with ivermectin. the situation in central africa has not yet been clearly assessed. | 2016 | 26926855 |
| the mitogenome of onchocerca volvulus from the brazilian amazonia focus. | we report here the first complete mitochondria genome of onchocerca volvulus from a focus outside of africa. an o. volvulus mitogenome from the brazilian amazonia focus was obtained using a combination of high-throughput and sanger sequencing technologies. comparisons made between this mitochondrial genome and publicly available mitochondrial sequences identified 46 variant nucleotide positions and suggested that our brazilian mitogenome is more closely related to cameroon-origin mitochondria th ... | 2016 | 26814648 |
| cutaneous onchocerciasis in dumbu, a pastoral area in the north-west region of cameroon: diagnostic challenge and socio-economic implications. | onchocerciasis is a severe parasitic infestation caused by onchocerca volvulus which causes disabling skin and subcutaneous tissue changes and ultimately leads to blindness. it has a huge public health impact due to its socioeconomic burden and the vast number of people it affects in developing countries. in this case, a 60 years old woman was encountered with leopard skin like changes, rashes and pruritus on the left leg; which had been managed as cutaneous mycosis for over a period of 8 years. ... | 2015 | 26966494 |