| geographical distribution of the subtype of hepatitis b surface antigen in chinese. | using the much more sensitive hemagglutination inhibition assay for subtyping of hepatitis b surface antigen (hbsag), we examined the determinants a, d, w and r in 192 from 228 hbsag positive adults who had been found after screening with reversed passive hemagglutination method. sixty-four subtypable cases were asymptomatic carriers and the remaining 128 were liver disease patients. among them there was no significant difference of the subtypes, invariably with adw as the main subtype. geograph ... | 1977 | 196971 |
| clustering of different subtypes of hepatitis b surface antigen in families of patients with chronic liver diseases. | clustering of hepatitis b surface antigen (hbsag) with both subtypes adr and adw in three families of patients with chronic liver diseases or hepatocellular carcinoma was demonstrated in taiwan where adw is the main subtype. the subtype in the children was similar to that in their mothers, suggesting maternal transmission. in all the family units clustered with different subtypes, the same pattern occurred, invariably with fathers carrying hbsag/adr and the children carrying hbsag/adw. the subty ... | 1978 | 210659 |
| hepatitis b virus infection and chronic liver disease in taiwan. | three hundred and eighty-five patients mostly with chronic liver diseases and 729 apparently healthy adults were studied for hepatitis b surface antigen (hbsag) with reversed passive hemagglutination and antibody (anti-hbs) with passive hemagglutination. in healthy adults around 15% was hbsag positive and in 45% was anti-hbs positive, estimating hepatitis b virus (hbv) infection in nearly two thirds of the population. the infection already occurred before adulthood. the prevalences of hbsag were ... | 1978 | 214987 |
| a seroepidemiologic study of hepatitis b virus infection in taiwan. | | 1978 | 284101 |
| hbeag and anti-hbe detection by radioimmunoassay: correlation with vertical transmission of hepatitis b virus in taiwan. | a sensitive radioimmunoassay technique was used to detect hepatitis b e antigen (hbeag). a strong correlation was found between hbeag positivity of the serum of hepatitis b surface antigen (hbsag) carrier women in taiwan and the subsequent development of surface antigenemia in their babies. all babies who became chronic hbsag carriers were born to hbeag positive women, maternal hbeag positivity being a better prior indication of chronic antigenemia developing in the baby than the hbsag titer in ... | 1979 | 479860 |
| hepatitis b virus infection on taiwan. | | 1977 | 757978 |
| influenza virus isolations from dogs during a human epidemic in taiwan. | during an islandwide outbreak of human influenza in june and july 1971, throat swabs were taken from dogs and cats in 3 urban communities of taiwan. eight influenza isolates were obtained from dogs in july 1971: two were identified as influenza a closely related to the human hong kong/68 virus, and one was a strain of influenza type b closely resembling human influenza b virus. the latter is the first such reported isolation from dogs under natural conditions. | 1976 | 977232 |
| anti-hcv antibody in chinese cirrhotic patients with or without hepatocellular carcinoma: relation to multitransfusion. | to investigate the positive rates of antibodies to hepatitis c virus (anti-hcv) in chinese cirrhotic patients with or without hepatocellular carcinoma and to evaluate the influence of blood transfusion on the prevalence of anti-hcv in such patients, a longitudinal study in 30 cirrhotic patients (17 combined with hepatocellular carcinoma) was carried out. five patients (16.7%) were anti-hcv positive before transfusion. the positive rate of anti-hcv in hbsag-positive patients and hbsag-negative pa ... | 1992 | 1315166 |
| hepatitis b virus infection among aboriginal children in eastern taiwan. | hepatitis b virus (hbv) infection is endemic in taiwan, with 15-20% of the adult population carrying the surface antigen (hbsag). hualien in eastern taiwan is relatively isolated from other parts of the island by the central mountains. the status of hbv infection among mountain aborigines in hualien has not been studied on a large scale before. a survey of serum hbsag and its antibody (anti-hbs) was conducted in 1989. a total of 3,287 children from 27 primary schools in three mountainous countie ... | 1992 | 1360296 |
| relationship between fatty liver, alanine aminotransferase, hbsag and hepatitis c virus. | a community health survey of 923 residents aged 30 years or more was performed in putai township of taiwan. to elucidate the relationships between hepatitis c virus (hcv) and surrogate tests for non-a, non-b hepatitis in hyperendemic areas of hepatitis b virus (hbv) serum levels of alanine aminotransferase (alt), triglycerides, cholesterol, hepatitis b surface antigen (hbsag) and antibody to hcv (anti-hcv) were examined. glucose tolerance tests and the history of diabetes treatment were used to ... | 1992 | 1382655 |
| current seroepidemiology of hepatitis d virus infection among hepatitis b surface antigen carriers of general and high-risk populations in taiwan. | in order to assess the current seroepidemiology of hepatitis d virus (hdv) infection in taiwan where hepatitis b virus (hbv) is hyperendemic, a total of 756 voluntary blood donors, 641 prostitutes, 1,014 patients with sexually transmitted diseases (stds), and 628 drug abusers were studied. radioimmunoassays were used for testing hbv infection markers and antibody against hdv (anti-hdv) among hbsag carriers. the anti-hdv prevalence among hbsag carriers was significantly higher in std patients (9. ... | 1992 | 1460460 |
| [seroepidemiological analysis of hepatitis b virus infection between anesthesia personnel and hospital administration staffs in changhua christian hospital]. | for hospital personnel, transmission of virus is a common and serious occupational hazard. other than suffering from physical discomfort, these infected hospital staffs may also transmit the disease to patients through their blood, mucous or secretion contamination. the purpose of this study is intended to understand the condition of hepatitis b virus infection between anesthetists and hospital administration staffs. forty-six anesthetists (study group) and 90 hospital administration staffs (con ... | 1992 | 1528103 |
| prevalence of antibodies to hepatitis c virus (anti-hcv) in different populations in taiwan. | the prevalence of antibodies to hepatitis c virus (anti-hcv) was investigated among different populations in taiwan, where anti-hcv was detected in 0.8% (24/2,994) of adult volunteer blood donors, 0.1% (1/1,305) of youngsters and children, 12.5% (8/64) of adult volunteer blood donors with elevated alanine aminotransferase (alt), 36.5% (23/63) of hemodialysis patients, 4.1% (13/318) of male homosexuals, 25.4% (16/63) of cases positive for antibodies to human immunodeficiency virus (anti-hiv), 82. ... | 1991 | 1657545 |
| [changing seroepidemiology pattern of hepatitis b virus infection among elementary and junior high school children in keelung, taiwan, 1988]. | a large-scale seroepidemiologic study of 20816 (35.6% of total) elementary and junior high school children (grades 1-9) in keelung, taiwan was conducted in april-may 1988. the study was to investigate the current status of hepatitis b virus (hbv) infection and to plan the extension of the present hbv prevention program to other age groups. two hbv markers, hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs), were determined by enzyme immunoassay. the overall seroposit ... | 1991 | 1677404 |
| minimal role of hepatitis b virus in posttransfusion non-a, non-b hepatitis in taiwan: a study by polymerase chain reaction. | using the polymerase chain reaction (pcr) for hepatitis b virus (hbv) dna and an enzyme linked immunosorbant assay for the antibody to the hepatitis c virus (anti-hcv), we studied the serum samples of 18 patients with posttransfusion non-a, non-b (nanb) hepatitis in a prospective study. they were all negative for both the hepatitis b surface antigen (hbsag) and the igm antibody to the hepatitis b core antigen (igm anti-hbc) by radioimmunoassay and were all negative for hepatitis b virus (hbv) dn ... | 1991 | 1680985 |
| prevalence of antibody to hepatitis c virus in pregnant taiwanese. | to assess the prevalence of an antibody to hepatitis c virus (anti-hcv) in pregnant women in taiwan, and elucidate whether or not there is superinfection of the hepatitis b virus (hbv) in such cases, we investigated two independent groups of pregnant women. group a included 294 without serum alanine aminotranferase (alt) screening, and group b included 171 pregnant women with an abnormal alt level (greater than 45 iu/l) who were recruited from 9,523 pregnant women screened for alt. blood samplin ... | 1991 | 1680986 |
| seroprevalence of hepatitis b virus infection in children in taipei, 1989: five years after a mass hepatitis b vaccination program. | a nationwide hepatitis b vaccination program was launched in taiwan in 1984. to study the impact of this ongoing program on hepatitis b virus (hbv) infection, a follow-up seroepidemiologic study was carried out in 1989 in a taipei district where pre-vaccination seroepidemiology had been studied. hbv markers were studied in 1134 apparently healthy children (619 boys and 515 girls) under 13 years of age between march and july 1989. the prevalence of hepatitis b surface antigen (hbsag) in children ... | 1991 | 1832440 |
| effects of hepatitis b virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma. | independent and interactive effects related to the development of hepatocellular carcinoma were assessed using a community-based case-control study for hepatitis b virus, habitual alcohol drinking, cigarette smoking, peanut consumption and history of hepatocellular carcinoma among the immediate family. all 200 male newly diagnosed hepatocellular carcinoma patients were recruited consecutively through the period of study as the case group from two teaching medical centers in northern and southern ... | 1991 | 1847891 |
| lack of immunity to hepatitis b virus among the expatriates residing in southern taiwan. | taiwan is an endemic area for hepatitis b virus (hbv) infection. there are more than 3-million carriers on this island. chronic hbv infections may result in liver cirrhosis and hepatocellular carcinoma, which are common in taiwan. however little information is available concerning the immunity and the susceptibility to hbv among the expatriate-population (non-permanent residents from foreign countries) in taiwan. thus controversies exist on the indications for hbv vaccination among the foreign v ... | 1991 | 1885944 |
| hepatitis c virus infection in patients with chronic liver diseases in an endemic area for hepatitis b virus infection. | taiwan is an endemic area for hepatitis b virus (hbv) infection, which is responsible for up to 80% of chronic liver diseases there. in contrast to an hbv carrier rate of 15-20% in the general population, only 1% of its population are seropositive for anti-hcv. to evaluate the role of hcv infection in chronic liver diseases in taiwan, serum anti-hcv was studied using an enzyme immunoassay in 123 "healthy" administration staff of the hospital, 724 hepatitis b surface antigen (hbsag)-positive and ... | 1991 | 1909260 |
| hepatitis d virus infection in a hyperendemic area of chronic hepatitis b virus infection: the taiwan experience. | | 1991 | 2020724 |
| horizontal transmission of hepatitis b virus from siblings and intramuscular injection among preschool children in a familial cohort. | the authors followed 147 children from 113 families who were susceptible to hepatitis b virus infection for a total of 275 person-years. among these children, 19 became infected with the hepatitis b virus and thus became new subclinical cases. in this cohort study, parents played a minor role in hepatitis b virus horizontal transmission. on the other hand, the estimated incidence rate ratio of hepatitis b virus infection for siblings of a hepatitis b e antigen (hbeag) carrier was 2.8 (95% confid ... | 1991 | 2035502 |
| serum hepatitis b virus dna in healthy hbsag-negative chinese adults evaluated by polymerase chain reaction. | serum hepatitis b virus (hbv) dna was assayed using polymerase chain reaction, in 107 hbsag-negative normal chinese subjects. the results showed that eight subjects (7.5%) had hbv dna. in the subgroup with antibody to hepatitis b surface antigen (anti-hbs) and to hepatitis b core antigen (anti-hbc), 7.3% (5/68) were positive for hbv dna; hbv dna was not detected in six individuals with anti-hbs only and in nine with anti-hbc only. in four persons with anti-hbc and anti-hbe, one had hbv dna. in 2 ... | 1990 | 2081972 |
| identification and characterization of intrahepatic hepatitis b virus dna in hbsag-seronegative patients with chronic liver disease and hepatocellular carcinoma in taiwan. | to clarify the role of hepatitis b virus infection in hbsag-seronegative patients with chronic liver disease and hepatocellular carcinoma in taiwan, we examined the hepatitis b virus dna in liver biopsy tissues of 112 patients by southern blot analysis. the patients studied included 43 patients with nonalcoholic chronic liver disease, 21 patients with hepatocellular carcinoma and 48 control patients with other hepatobiliary and gastrointestinal diseases. to confirm the specificity of the intrahe ... | 1990 | 2169454 |
| complications of bone marrow transplantation in chinese. | forty-three patients with hematopoietic disease were treated with intensive chemotherapy and radiotherapy, followed by allogeneic bone marrow transplantation (bmt) from 28 hla-identical and 10 one to two antigen haploidentical sibling donors and autologous bmt (5 cases). of these cases, there were 21 with acute nonlymphocytic leukemia (anll), 5 with acute lymphocytic leukemia (all), 6 with chronic myelocytic leukemia (cml), 2 with hodgkin's disease (hd), 8 with severe-form aplastic anemia (saa) ... | 1990 | 2323672 |
| an increased risk of hepatitis b virus infection from tattooing in taiwan. | from among 2,375 young men, examined by doctors, 111 tattooed subjects were found. twenty one subjects reported engaging in promiscuous sexual behavior or being intravenous drug abusers, and so were excluded. the other 90 were evaluated. to make up the control group, 180 non-tattooed subjects from the remaining 2,264, who neither engaged in promiscuous sexual activity nor were intravenous drug abusers, were matched from household registry reports by age, sex, education, occupation, and geographi ... | 1990 | 2362302 |
| sexual transmission of hepatitis d virus infection in taiwan. | multivariate analysis of the risk factors for hepatitis d virus infection among 53 men with acute hepatitis d virus superinfection, 59 men with acute exacerbation of chronic hepatitis b and 54 asymptomatic male hepatitis b carriers revealed that sexual contact with prostitutes and use of nondisposable needles were the factors significantly associated with hepatitis d virus infection in taiwan (odds ratio = 5.5, 95% confidence interval = 3.3 to 9.2; odds ratio = 2.4, 95% confidence interval = 1.3 ... | 1990 | 2365283 |
| hepatitis d virus infection among intravenous drug abusers in taiwan: analysis of risk factors and liver function tests. | to investigate the prevalence of hepatitis d virus (hdv) and hepatitis b virus (hbv) infection among intravenous drug abusers in taiwan, a total of 761 male prisoners, including 680 intravenous drug abusers, were studied for serological markers of hbv and hdv. questionnaires were distributed to evaluate the risk factors for hdv infection and also to estimate the strength of association among hdv infection and the risk factors. hbv infection was common, and the positive rates of hbv markers betwe ... | 1990 | 2388047 |
| early detection of hepatocellular carcinoma in patients with chronic type b hepatitis. a prospective study. | a prospective surveillance of hepatocellular carcinoma (hcc) using serum alpha-fetoprotein and high-resolution, linear-array, real-time ultrasonography was carried out in 432 patients with clinicopathologically proven chronic type b hepatitis. during a follow-up period of 6-85 mo (median 23, mean 26.9 +/- 16.8 mo), asymptomatic hcc was identified in 8 patients, with a calculated annual incidence of 826/100,000, and 2768/100,000 for patients over age 35 yr. the relative risk of developing hcc in ... | 1986 | 2416625 |
| alpha-fetoprotein monitoring in chinese patients with chronic hepatitis b virus infection: role in the early detection of hepatocellular carcinoma. | two hundred ninety patients (203 men, 87 women), age 7 to 74 years (mean: 39.1 years), with chronic hepatitis b virus infection, were prospectively followed for a period of 1 to 4 years to determine the value of alpha-fetoprotein monitoring in the early detection of hepatocellular carcinoma. at presentation, 66% of the patients were asymptomatic, 19% had chronic hepatitis and 15% had established cirrhosis. forty-four (15%) patients had elevated alpha-fetoprotein levels on one or more occasions d ... | 1989 | 2461890 |
| changing aetiologic patterns of acute viral hepatitis in taiwanese children. | during 1981-86, 76 children were diagnosed as having acute viral hepatitis at the department of pediatrics, national taiwan university hospital, which is a major referral centre for hepatitis in children in northern taiwan. the majority (64%) of children had acute hepatitis b which had occurred mainly during infancy. perinatal transmission from a hepatitis b e negative surface antigen (hbsag) carrier mother or infection through blood transfusion from a donor who had escaped notice by a less sens ... | 1989 | 2535240 |
| membranous nephropathy in 52 hepatitis b surface antigen (hbsag) carrier children in taiwan. | to elucidate the prognosis and the causative viral antigens of hepatitis b virus (hbv)-associated childhood membranous nephropathy (mn), the clinical course and glomerular hbv antigens were studied in 52 hbsag carrier children with mn (40 boys, 12 girls). with fab fragments of monoclonal antibodies, hepatitis be antigen (hbeag) was detected in the glomerular deposits in 41 (95%) of 43 cases but hbsag and hepatitis b core antigen (hbcag) in none. hbeag was detected in sera from 43 (93%) of 46 chi ... | 1989 | 2689751 |
| immunization of newborns of hbsag-positive mothers: a successful first step in control of hepatitis b virus in taiwan. | | 1989 | 2714740 |
| acute viral hepatitis in chronic carriers of hepatitis b virus: different patterns in different places. | | 1989 | 2744733 |
| seroepidemiology of hepatitis b virus, hepatitis d virus, and human immunodeficiency virus infections among parenteral drug abusers in southern taiwan. | a total of 390 parenteral drug abusers (pdas) at the kaohsiung municipal narcotics abstention institute were examined for markers of hepatitis b virus (hbv), hepatitis d virus (hdv), and human immunodeficiency virus (hiv). all sera were tested for hepatitis b surface antigen (hbsag), surface antibody (anti-hbs), and core antibody (anti-hbc) by radioimmunoassay (ria) and for antibody to hiv (anti-hiv) by enzyme-linked immunosorbent assay (elisa). hepatitis b e antigen (hbeag) and antibody to hdv ... | 1989 | 2778445 |
| childhood hepatocellular carcinoma develops exclusively in hepatitis b surface antigen carriers in three decades in taiwan. report of 51 cases strongly associated with rapid development of liver cirrhosis. | to elucidate the etiologic role of chronic hepatitis b virus (hbv) infection and the role of liver cirrhosis in hepatocellular carcinoma (hcc), pathologic and virologic features of the disease were studied in 51 children with hcc; these accounted for 4.3% of 1195 pathologically proven hcc patients examined in the last three decades. males predominated (m/f = 3.3:1), and the mean age was 11 years (range: 4-15 years). hepatitis b surface antigen (hbsag) was detected in the liver and/or serum of 10 ... | 1987 | 2828461 |
| anti-hbc igm in cases of hepatocellular carcinoma and cirrhosis in taiwan. | the sera of apparently healthy carriers of hepatitis b virus surface antigen enrolled in the taiwan prospective study were tested retrospectively for anti-hbc igm, to determine whether this test would be useful in predicting the development of hepatocellular carcinoma (hcc) and/or cirrhosis. in comparison with men who did not develop hcc or cirrhosis, the relative risk of those with anti-hbc igm elevations was 3.4 and 5.6, respectively. each of these factors was highly statistically significant, ... | 1987 | 2828462 |
| hepatitis b virus. the major etiology of hepatocellular carcinoma. | | 1988 | 2834034 |
| evolution of expression of hepatitis b surface and core antigens (hbsag, hbcag) in resected primary and recurrent hepatocellular carcinoma in hbsag carriers in taiwan. correlation with local host immune response. | studies were conducted on the evolution of hepatitis b virus (hbv) surface and core antigens (hbsag and hbcag) in the tumors of both primary and recurrent hepatocellular carcinoma (hcc) in 27 hbsag carriers; these were followed for up to 8 years after the resection of the primary tumor. twenty-seven primary and 34 recurrent tumors were included. hbv antigens were detected in the tumor of the primary hcc in ten cases (37%): six (22.2%) had both antigens (group i) and four (14.8%) had hbsag alone ... | 1988 | 2842026 |
| a case-control study of primary hepatocellular carcinoma in taiwan. | a case-control study was carried out to explore possible risk factors of primary hepatocellular carcinoma (phc) in taiwan. one hundred thirty-one phc patients and 207 hospital control patients were interviewed and blood samples were collected for blood type and hepatitis b virus (hbv) infection marker tests. eighty-three percent of the phc patients were found to be hepatitis b surface antigen (hbsag) positive as compared with 21.0% of the control patients with an odds ratio (or) of 21.5. hepatit ... | 1988 | 2844388 |
| female to male transmission of hepatitis b virus between chinese spouses. | three hundred thirty-seven community-based spouses were tested for the presence of hepatitis b virus (hbv) markers to assess the direction of hbv transmission between couples. the prevalence rate of hbv infection among husbands whose wives were hepatitis b surface antigen (hbsag)-positive was higher compared with those whose wives were hbsag-negative. moreover, the frequency of hbv seropositivity among husbands was 100% if their wives carried hbeag and showed a trend correlation (p = .009). the ... | 1989 | 2921601 |
| baseline seroepidemiology of hepatitis b virus infection in children in taipei, 1984: a study just before mass hepatitis b vaccination program in taiwan. | hepatitis b virus (hbv) markers were studied by radioimmunoassays in serum samples of 1,200 (647 male, 553 female) apparently healthy children under 15 years of age in taipei between june and october 1984. the prevalence rate of hepatitis b surface antigen (hbsag) was 5.1% in infancy, increased to 10.7% between 1 and 2 years of age, and then remained constant at about 10% thereafter. the prevalence rate of surface antibody (anti-hbs), core antibody (anti-hbc), and seropositivity (at least one ma ... | 1986 | 2940332 |
| efficacy of a mass hepatitis b vaccination program in taiwan. studies on 3464 infants of hepatitis b surface antigen-carrier mothers. | to evaluate the efficacy of the mass hepatitis b vaccination program in taiwan in interrupting perinatal hepatitis b virus transmission, 3464 randomly selected 18-month-old infant vaccinees born to hepatitis b surface antigen-carrier mothers were recruited from 9697 eligible infants during a six-month period of the program. they were divided into ten groups according to maternal infectivity and compliance with the vaccination schedule. serum samples were tested for hepatitis b surface antigen, a ... | 1988 | 2971827 |
| restriction endonuclease mapping of the hepatitis b viral genome isolated from taiwan. | the eco ri fragment of hepatitis b virus (hbv) dna isolated from human blood plasma dane particles were inserted into plasmid puc8 eco ri site and transformed into e. coli jm103 host. two recombinants ptwl1 and ptwl2 were found to carry 3.2 kbp fragment and proved to have hbv genome by southern hybridization method. the 1.4 kbp bam hi fragment which carried the hepatitis b viral surface antigen (hbsag) gene, obtained via bam hi digestion of dane particles dna which was made fully double stranded ... | 1985 | 2996043 |
| mortality of hepatoma and cirrhosis of liver in taiwan. | a study of mortality from hepatoma and hepatic cirrhosis was conducted in taiwan, where their mortality rates are among the highest in the world in 1980 being 26.10 and 8.14 per 100,000 population for males and females, respectively, for hepatoma, and 33.01 and 12.90 for males and females, respectively, for cirrhosis. the secular trends of hepatoma and hepatic cirrhosis death rates have been increasing, especially in males, with consequent increase in the sex ratio. the large difference in morta ... | 1986 | 3026426 |
| fulminant hepatitis in children in taiwan: the important role of hepatitis b virus. | in a recent period of 64 months, fulminant hepatitis was diagnosed in 17 children at national taiwan university hospital. eleven patients were younger than 12 months of age. hepatitis a igm antibody and delta-antibody were negative in all 17. eleven (65%) patients had hepatitis b core igm antibody, fulminant hepatitis b. two to 5 months before onset of hepatitis. five of the 11 children had received blood transfusions. three of the five donors had hepatitis b e antibody (anti-hbe) and were hepat ... | 1987 | 3110389 |
| the aetiology of acute hepatitis in taiwan: acute hepatitis superimposed on hbsag carrier state as the main aetiology of acute hepatitis in areas with high hbsag carrier rate. | the aetiology of sporadic acute hepatitis in taiwan was studied in a consecutive series of 273 patients, 209 males and 64 females, aged from less than 1 to 73 years. only eight patients (2.9%) had acute hepatitis a, 36 (13.2%) acute hepatitis b and 57 (20.9%) had acute non-a, non-b hepatitis (nanb). the remaining 172 patients (63.0%) were hbsag positive but anti-hbc igm negative and were classified as acute hepatitis in chronic hbsag carriers. age-specific analysis revealed that acute hepatitis ... | 1988 | 3141291 |
| combined passive and active immunization for interruption of perinatal transmission of hepatitis b virus in taiwan. | we attempted a clinical trial to interrupt transmission of hepatitis b virus (hbv) infection from hepatitis b surface antigen (hbsag) positive and hepatitis be antigen (hbsag) positive mothers to their infants in taiwan. screening of 5,595 pregnant women revealed that 856 (15.3%) were hbsag positive. three hundred and sixty-one (42.2%) of the hbsag positive pregnant women were hbeag positive. infants born to hbsag and hbeag positive mothers were randomized into 3 groups to receive the hbv vaccin ... | 1985 | 3159639 |
| seroepidemiological studies on hepatitis b and d viruses infection among five ethnic groups in southern taiwan. | in order to compare the prevalence of hepatitis b virus (hbv) and hepatitis d virus (hdv) infection among five ethnic groups in pingtung county of southern taiwan, a total of 240 serum samples were collected from september to october, 1985, from the following five ethnic groups: taiwanese, hakka, mainland chinese, aboriginal paiwanese, and aboriginal rukaiese. ages of subjects ranged from 5 to 69 years. all sera were tested for hepatitis b surface antigen (hbsag), surface antibody (anti-hbs), an ... | 1988 | 3209993 |
| hepatitis b virus infection in children in taiwan. | | 1988 | 3273357 |
| assessment of hbv persistent infection in an adult population in taiwan. | in order to study the prevalence of hepatitis b virus (hbv) in the adult population of taiwan, we screened for the presence of hbv dna in 205 blood samples from adult (20-59-year-old) volunteers. according to the serological markers of hbv, samples were divided into three groups: group i (173 subjects) was negative for both hbsag and hbeag; group ii (14 subjects) was positive for both hbsag and hbeag; and group iii consisted of 18 subjects who were hbsag-positive but hbeag-negative. plasma hbv d ... | 1988 | 3367138 |
| symptomatic anti-hbe positive chronic hepatitis b in taiwan with special reference to persistent hbv replication and hdv superinfection. | ninety-four patients, who were admitted with symptoms of liver disease and found to be positive for hepatitis b surface antigen and antibody to hepatitis b e antigen (anti-hbe), were examined for hepatitis b virus (hbv) dna in serum and immunoglobulin antibody to hepatitis b core antigen and liver biopsies were stained for hepatic hepatitis b core antigen. of 94 patients, 34 (36%) had evidence of hbv replication and 35 (37%) evidence of hepatitis d virus (hdv) superinfection. most of the latter ... | 1988 | 3392522 |
| delta infection in asymptomatic carriers of hepatitis b surface antigen: low prevalence of delta activity and effective suppression of hepatitis b virus replication. | we examined the prevalence of serum anti-delta antibody among 769 intravenous drug abusers in taiwan. delta infection was found extremely common in the hbsag-positive carriers with drug abuse, because 128 (85%) of 151 carriers were positive for anti-delta. however, most of antibody titers were low (less than 1:5,000). by molecular hybridization, delta rna genomes were detectable in only five (4%) of 128 asymptomatic carriers positive for anti-delta. the results suggested that most of them had pr ... | 1988 | 3417233 |
| perinatal transmission of hepatitis b virus in the taoyuan area. | | 1986 | 3462318 |
| [prevalence of hepatitis b virus infection among hospital personnel]. | | 1986 | 3482690 |
| [an epidemiological study on hepatitis b virus infection in kaohsiung medical college freshmen]. | | 1987 | 3482998 |
| correlation between hepatic hepatitis b core antigen and serum hepatitis b virus-dna levels in patients with chronic hepatitis b virus infections in taiwan. | paired liver biopsy specimens and serum samples from 76 patients with chronic hepatitis b virus (hbv) infection were taken for staining of hepatitis b core antigen (hbcag) by immunoperoxidase and testing of hbv-dna by a spot hybridization technique, respectively. thirty-two tissue specimens showed positive staining for hbcag in their hepatocytes. the two patients with diffuse hbcag expression in liver tissue also had high serum concentrations of hbv-dna (greater than 10 pg/10 microl). among 30 p ... | 1987 | 3545139 |
| a mass vaccination program in taiwan against hepatitis b virus infection in infants of hepatitis b surface antigen-carrier mothers. | to combat hepatitis b virus (hbv) infection in taiwan, a mass immunoprophylaxis program was launched on july 1, 1984, aiming first at prevention of chronic hbv carriage from perinatal mother-to-infant infection. in the first 15-month period, 352,721 (78%) of 450,585 pregnant women were screened for hepatitis b surface antigen (hbsag); hbsag was present in 62,359 (18%), with 50% of them categorized as highly infectious. infants born to hbsag-positive women were given 5 micrograms of a plasma-deri ... | 1987 | 3573257 |
| [epidemiological study on hepatitis b virus infection among five ethnic groups in pingtung county, taiwan]. | | 1987 | 3625156 |
| analysis of the dna of hepatitis b virus in the sera of chinese patients infected with hepatitis b. | | 1986 | 3701109 |
| hepatitis b and d virus infection among drug abusers in taiwan. | approximately 15 to 20% of the general population in taiwan are chronic hepatitis b surface antigen (hbsag) carriers. however, the incidence of hepatitis d virus (hdv) infection is low (5-8%) in patients with hbsag-positive chronic liver diseases in this area. to evaluate the prevalence of hepatitis b virus (hbv) and hdv infection among drug abusers in taiwan, serum samples were collected from 152 drug abusers at the taipei municipal anti-narcotic institute and test for hbv and hdv markers. of t ... | 1986 | 3783132 |
| occupational exposure to hepatitis b virus among hospital personnel. | | 1985 | 3864921 |
| natural history of chronic hepatitis b virus infection in taiwan: studies of hepatitis b virus dna in serum. | hepatitis b virus dna (hbv dna) in serum was measured by a spot hybridization technique in a consecutive series of 79 cases with chronic hbv infection from taiwan. hbv dna was found in 96.3% (52/54) of hbeag-positive, 66% (2/3) with neither hbeag or anti-hbe and in 63.6% (14/22) of anti-hbe positive patients. the levels of hbv dna in the hbe-ag-positive patients were significantly higher than in the anti-hbe positive patients (median, 944 vs. 58 pg per ml, p less than 0.001). the mean ages incre ... | 1985 | 3997072 |
| inadequacy of immunoglobulin m hepatitis b core antibody in detecting acute hepatitis b virus infection in infants of hbsag carrier mothers. | to study the usefulness of igm hepatitis b core antibody (anti-hbc igm) for detecting hepatitis b virus infections in infants of hepatitis b surface antigen (hbsag) carrier mothers, serial serum samples from 86 infants of carrier mothers were tested for anti-hbc igm with a highly specific enzyme immunoassay. asymptomatic hepatitis b infection occurred frequently in infants under 12 mo of age. anti-hbc igm never became positive in 25 infants infected under 9 mo old. it was positive in only 1 of 6 ... | 1985 | 4031828 |
| hepatocellular carcinoma and hepatitis b virus. | | 1984 | 6087457 |
| hepatocellular carcinoma and hepatitis b virus. a prospective study of 22 707 men in taiwan. | | 1981 | 6118576 |
| immunogenicity of hepatitis b virus vaccine in healthy chinese neonates. | the immunogenicity of hepatitis b virus vaccine was studied in 38 chinese neonates, 23 of whom were healthy and susceptible and 15 of whom had passive serum antibody to hepatitis b surface antigen (anti-hbs). initially, each infant received two 20-micrograms doses of vaccine by the intramuscular route, with a one-month interval between doses. no adverse reactions occurred, and all susceptible neonates had a brisk antibody response that was comparable to that in older infants and children and sup ... | 1983 | 6225807 |
| immunogenicity of hbv vaccine in healthy chinese children. | the immunogenic response of healthy chinese children to three different doses of hepatitis b virus (hbv) vaccine was compared. one hundred susceptible children received two doses of 10, 20 or 40 micrograms a month apart. a month following the first dose 33% of all the children had antibodies. the response rate rose to 78% a month later and 99% four months later. ninety percent of the 100 children still had antibody at 12 months after vaccination was initiated. the response rate, antibody levels ... | 1983 | 6241767 |
| hepatitis b surface antigen and hepatocellular carcinoma in the people's republic of china. | eighteen cases of heptocellular carcinoma from the people's republic of china were investigated for the presence of hepatitis b surface antigen (hbsag) in the cytoplasm of hepatocytes and tumor cells. the sternberger-pap immunoperoxidase technique utilizing monospecific antibody to hbsag and a modified orcein method demonstrated cytoplasmic hbsag in hepatocytes of 15 cases (83.3%) and tumor cells of 3 cases (16.7%). thirteen of these cases were also investigated for hbs antigenemia and of these ... | 1980 | 6251965 |
| maternal transmission of hepatitis b surface antigen in patients with hepatocellular carcinoma in taiwan. | to determine the source of the highly prevalent hepatitis b virus (hbv) infection in our patients with hepatocellular carcinoma (hcc), we examined hepatitis b surface antigen (hbsag) and its subtypes and antibody in 11 patients with hcc and their parents. all the patients were positive for hbsag. eight (73%) of the mothers were also hbsag-positive, whereas only one of the seven fathers was an hbsag carrier (p = 0.025). the observation is compatible with maternal transmission as a source of hbv i ... | 1980 | 6254137 |
| hepatitis b virus and primary hepatocellular carcinoma: family studies in korea. | chronic infection with hepatitis b virus (hbv) is closely associated with the etio-pathogenesis of primary hepatocellular carcinoma (phc). it has been proposed that infection with hbv early in life, frequently transmitted by an hbv-carrier mother, leads to persistent infection with hbv, which in turn is associated with the development of chronic active hepatitis (cah), post-necrotic cirrhosis and phc. if this view is correct, then there should be clustering of chronic carriers of hbv in families ... | 1982 | 6288579 |
| hepatitis-b surface antigen and hepatocellular carcinoma in taiwan. with special reference to types and localization of hbsag in the tumor cells. | the relationship between hepatitis b virus (hbv) infection and hepatocellular carcinoma (hcc), with or without cirrhosis, was assessed immunopathologically through the detection of tissue hepatitis b surface antigen (hbsag) on paraffin sections of 284 biopsy and surgical specimens of hcc, which were performed from 1970 to 1979, by the indirect immunoperoxidase technique. in 190 cases with nontumorous liver tissue available for histologic and etiologic analyses, cirrhosis was identified in 69.8% ... | 1983 | 6313175 |
| fraternal hepatocellular carcinoma in young children in two families. | two pairs of young brothers from two families with histologically verified hepatocellular carcinoma (hcc) occurred with almost simultaneous onset in each family. in the first family, the boys were 5 and 7 years of age, respectively. both of them, their parents, and a younger sister were hepatitis-b-surface-antigen (hbsag)-positive. in the second family, the two brothers were 9 and 7 years of age, respectively. both patients, their mother, and maternal grandmother were hbsag-positive. the fratern ... | 1984 | 6321015 |
| age-specific prevalence and significance of hepatitis b e antigen and antibody in chronic hepatitis b virus infection in taiwan: a comparison among asymptomatic carriers, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. | the age-specific prevalence of hepatitis b e antigen (hbeag) and its antibody (anti-hbe) were studied by radioimmunoassay, and compared in a large series of patients with chronic hepatitis b virus (hbv) infection, including 268 asymptomatic carriers, 389 chronic hepatitis, 114 liver cirrhosis, and 278 hepatocellular carcinoma (hcc). the prevalence of hbeag/anti-hbe in asymptomatic carriers and patients with chronic hepatitis correlated closely with age as hbeag prevalence decreased and anti-hbe ... | 1984 | 6330293 |
| efficacy of hepatitis b immune globulin for prevention of perinatal transmission of the hepatitis b virus carrier state: final report of a randomized double-blind, placebo-controlled trial. | a randomized double-blind, placebo-controlled efficacy trial of hepatitis b immune globulin (hbig) for prevention of the mother-to-infant transmitted hbsag carrier state was conducted in taiwan where the carrier rate in the general population is 15 to 20%. hbig was given immediately after birth to infants of e antigen positive hbsag carrier mothers, and all infants were followed for at least 15 months. among 61 placebo recipients, the carrier rate was 92%; compared with 26% among 57 infants who ... | 1983 | 6339349 |
| association of hepatitis b surface (hbs) antigenemia and membranous nephropathy in children in taiwan. | fourteen out of 63 children with primary glomerular disease had membranous nephropathy (mn) that was not associated with systemic lupus erythematosus. hepatitis b surface antigen (hbsag) was detected in the sera of all 13 patients tested, but was found in only 6.25% of their parents, in 28.57% of their siblings, and in 18.8% of the children with other types of primary glomerular disease. these findings strongly suggest that mn in children in taiwan is closely related to hepatitis b virus (hbv) i ... | 1983 | 6354538 |
| hepatitis b virus infection and its sequelae in taiwan. | | 1984 | 6489693 |
| hepatitis b virus infection in taiwan with reference to anti-hbc versus hbsag and anti-hbs. | | 1980 | 6939789 |
| incidence of hepatitis b virus infections in preschool children in taiwan. | to determine the incidence of infections with hepatitis b virus (hbv) among chinese preschool children, 1,510 children (mean age, 29 months) were tested for hbv markers; 15.9% were infected with hbv (7.8% positive for hepatitis b surface antigen [hbsag] and 8.1% positive for antibody to hbsag) and 84.1% were susceptible when the children were enrolled in the study. the average length of follow-up was 2.1 years among 1,110 children. among the 924 susceptible children who were followed up, 10.6% h ... | 1982 | 7108271 |
| hepatitis b e antigen and antibody in asymptomatic chinese with hepatitis b surface antigenemia in taiwan. | two hundred and twenty two asymptomatic carriers of hepatis b surface antigen (hbsag) with age between 4 months and 68 years, 172 healthy persons with antibody to hbsag (anti-hbs) and 85 healthy persons seronegative for both hbsag and anti-hbs were studied by double immunodiffusion for the evaluation of the meaning of hepatitis b e antigen (hbeag) and its antibody (anti-hbe). in 222 asymptomatic carriers, hbeag was detected in 32.4% and anti-hbe in 31.5%. the geometric titer of hbsag was 1:2159 ... | 1982 | 7141198 |
| hbeag and anti-hbe in chronic hepatitis b virus infection. | | 1981 | 7202958 |
| low prevalences of hbv and hcv infection in patients with primary biliary cirrhosis in taiwan: a case control study. | to study the role of hepatitis b virus (hbv) and hepatitis c virus (hcv) infection in patients with primary biliary cirrhosis (pbc) against the background of hbv and hcv infection in the general population, serum specimens from a consecutive series of 27 patients with pbc and 108 age/sex matched 'healthy subjects' as control group were submitted to assays for hepatitis b surface antigen (hbsag), antibody to hepatitis b core antigen (anti-hbc), antibody to hepatitis b surface antigen (anti-hbs) a ... | 1993 | 7506585 |
| the role of hepatitis c virus in chronic hepatitis b virus infection. | to investigate the influence of hepatitis c virus (hcv) infection on patients with chronic hepatitis b virus (hbv), the presence of antibody against c100-3 antigen of hcv (anti-hcv) was examined in 420 patients with chronic hbv infection and 275 healthy subjects. it was found that the prevalence of hcv infection increased in parallel with the severity of liver damage. the positive rates of anti-hcv were as follows: healthy subjects, 2.9% (8/275); asymptomatic carriers, 2.6% (5/193); chronic hepa ... | 1993 | 7689504 |
| precore mutant of hepatitis b virus in childhood fulminant hepatitis b: an infrequent association. | serum hbv dna from infants and children with fulminant hepatitis b (fhb) or acute self-limiting hepatitis b (ahb) and patients believed to be contamination sources was amplified by polymerase chain reaction (pcr) followed by direct sequencing of the precore region. a precore mutation from g to a at nucleotide 1896 was found in 5 of 14 fhb patients and in 3 of 10 ahb patients. among the 10 infants who developed hepatitis during the first 6 months of age, the precore mutation was detected in only ... | 1995 | 7706802 |
| liver disease after bone marrow transplantation--the taiwan experience. | to investigate the causes of impaired liver function (lf)* after bmt, 88 patients were included for analysis of hepatitis b virus (hbv) and hepatitis c virus (hcv) infections, transplant methods, preconditioning regimens, and graft-versus-host disease (gvhd). fifty of them (56.8%) developed abnormal lf after bmt and among them, 29 (32.9%) developed chronic hepatitis (ch). by univariate analysis, hcv infection, pretransplant abnormal lf, allogeneic bmt, and preconditioning regimen with total body ... | 1995 | 7732560 |
| long-term follow-up of hepatitis b virus carrier infants. | one hundred twenty-two hepatitis b surface antigen (hbsag) carrier infants were followed-up for 8-10 years. one hundred eleven had antibody to hepatitis b core antigen (anti-hbc; 83 had been vaccinated) and the remaining 11 were without anti-hbc (7 had been vaccinated). during the follow-up period, 29 (26.1%) carrier infants with anti-hbc had one or more episodes of alanine aminotransferase (alt) elevation and up to 32.8% (21/64) of the carriers in this group lost their hepatitis b e antigen (hb ... | 1994 | 7897365 |
| bone marrow transplantation in taiwan: an overview. | in taiwan, a country with 21 million people, 388 bone marrow transplants (bmts), 308 allografts and 80 autografts, were performed in 5 bmt centers from november 1983 to october 1993. the commonest indications were leukemia, aplastic anemia, lymphoma and thalassemia. campaigns promoting an unrelated marrow donor registry were started in august 1993 and recruited approximately 26,000 volunteers. a peripheral stem cell program is just beginning. the overall results of bmt in taiwan are comparable t ... | 1994 | 7920298 |
| analysis of integrated hepatitis b virus dna and flanking cellular sequences in the hepatocellular carcinoma cell line hcc36. | a hepatocellular carcinoma cell line, hcc36, was established from an adult hbv carrier in taiwan. from southern blot analysis, there were at least four sites of integration of hbv dna, and no viral replicative intermediates were detected. a genomic library was constructed from hcc36 dna, and two phage clones, designated lambda 36a and lambda 36b, were shown to contain hbv dna and flanking cellular sequences. in lambda 36a, hbv dna sequences were quite conserved, and 7.4% base variation was detec ... | 1994 | 7928289 |
| outcome of perinatal hepatitis b virus exposure is dependent on maternal virus load. | to evaluate the role of maternal hepatitis b virus (hbv) dna levels in perinatal infection, two nested case-control studies were done within a cohort of 773 hepatitis b surface antigen (hbsag)-positive taiwanese women and their infants. as serum hbv dna levels increased from < 0.005 to > or = 1.4 ng/ml among the hepatitis b e antigen (hbeag)-positive mothers, the odds ratio (or) for having a persistently infected infant increased from 1.0 to 147.0 (p for trend < .001). among hbeag-negative mothe ... | 1994 | 7995980 |
| multiple viral infection as the most common cause of fulminant and subfulminant viral hepatitis in an area endemic for hepatitis b: application and limitations of the polymerase chain reaction. | we tested serum samples from 25 fulminant hepatitis and 7 subfulminant hepatitis patients for hepatitis a, b, c, d and e viral markers and nucleic acids by means of polymerase chain reaction to determine the role of each virus on such catastrophic events in an area endemic for hepatitis b. of these 32 patients, 14 (44%) were hepatitis b virus carriers with hepatitis d virus superinfection (1 with hepatitis c virus infection), 3 others had coexisting hepatitis b virus and hepatitis c virus infect ... | 1994 | 8138254 |
| hepatitis b virus surface antigen as an interpretation factor for serum biochemical tests in young adults. | with ages between 14-17 years, none of the 2157 subjects studied in the central taiwan area had ever been inoculated with the hepatitis b vaccine. whether a hepatitis b virus surface variable, either the hepatitis b surface antigen (hbsag) or its antibody (anti-hbs), was an interpretation factor in reading laboratory data for a common serum biochemical test was analyzed by two-way analysis of variance (anova). the two independent variables were gender and the hepatitis b surface variable. either ... | 1993 | 8171166 |
| hepatitis b and hepatitis c among institutionalized psychiatric patients in taiwan. | to investigate the seroprevalence of hepatitis b surface antigen (hbsag) and antibodies to hepatitis c virus (anti-hcv) in a psychiatric institution in taiwan, where hepatitis b virus (hbv) is hyperendemic, a total of 780 patients with psychiatric disorders were studied. enzyme-linked immunosorbent assays (elisa) were used for testing hbsag and anti-hcv. the prevalence of hbsag was higher than that of anti-hcv among these patients (18.1% vs. 6.8%, p < 0.0001). the hbsag carrier rate in these pat ... | 1993 | 8360635 |
| prevalence of hepatitis c viral infection in a community in taiwan. detection by synthetic peptide-based assay and polymerase chain reaction. | the prevalence of antibodies to hepatitis c virus (anti-hcv) in a hepatitis b virus hyperendemic region was evaluated with a second-generation enzyme immunoassay. a general population of 1500 from northern taiwan was tested with this immunoassay which includes synthetic peptides from the capsid and non-structural protein region as the solid-phase antigen. a total of 37 subjects out of 1500 (2.5%) were positive, with no significant difference in distribution between hepatitis b antigenemic and no ... | 1993 | 8383160 |
| urinary aflatoxin levels, hepatitis-b virus infection and hepatocellular carcinoma in taiwan. | using a urinary immunoassay to measure aflatoxin metabolites, we examined the associations between exposure to aflatoxin, chronic infection with the hepatitis-b virus (hbv) and background rates of hepatocellular carcinoma (hcc) mortality in a cross-sectional survey of 250 residents from 8 areas of taiwan with a 4-fold variation in age-adjusted hcc mortality. specimens of fasting blood and overnight urines were used to determine hbv carrier status and excretion of aflatoxin in the subjects survey ... | 1993 | 8392983 |
| secular trend and geographical variation in hepatitis a infection and hepatitis b carrier rate among adolescents in taiwan: an island-wide survey. | during the last two decades an economic boom has occurred in taiwan, a region where the prevalence of both hepatitis a and b virus infection was formerly very high. to examine the impact of socioeconomic developments on the secular trend and geographical variation in hepatitis a and b virus infection, 875 adolescents selected randomly from 20 junior high schools were studied. serum samples collected from the subjects were tested for hepatitis a antibody (anti-hav) and hepatitis b surface antigen ... | 1993 | 8423454 |
| heterosexual transmission as the most common route of acute hepatitis b virus infection among adults in taiwan--the importance of extending vaccination to susceptible adults. | sixty adult patients with acute viral hepatitis b (avhb) and 93 controls were interviewed to assess potential risk factors of hepatitis b. heterosexual contact was the only significant factor, and it was associated with 83% of cases. a history of having new sex partners or multiple sex partners within 6 months before the onset of avhb or first sexual contact before 20 years of age were significantly associated with hbv infection (p < .005, respectively). there was a dose-response relationship be ... | 1993 | 8450259 |
| sex difference in chronic hepatitis b virus infection: studies of serum hbeag and alanine aminotransferase levels in 10,431 asymptomatic chinese hbsag carriers. | to study the difference between the sexes with regard to chronic hepatitis b virus infection, we surveyed levels of serum hepatitis b e antigen (hbeag) and alanine aminotransferase (alt) among 10,431 asymptomatic chinese carriers of hepatitis b surface antigen (hbsag) in taiwan. there were 7,095 men and 3,336 women in this study; ages ranged from 15 to 70 years. hbeag was detected in 19.6% of hbsag carriers. the prevalence of hbeag decreased significantly with increasing age. hbeag was detected ... | 1993 | 8507764 |
| alcoholism, hepatitis b and c viral infections, and impaired liver function among taiwanese aboriginal groups. | viral hepatitis and alcoholism prevail in four major taiwanese aboriginal groups. to study the relative importance of the acquisition of hepatitis b virus or hepatitis c virus infection and alcoholism to the presence of impaired liver function in these groups, the authors conducted a semistructured clinical interview for alcoholism and test for seromarkers for viral hepatitis among 993 cohort members enrolled in 1990-1992 in an ongoing prospective study (taiwan aboriginal study project). the sub ... | 1996 | 8610707 |
| ethnic differences in immune responses to hepatitis b vaccine. | a national vaccination program against hepatitis b virus (hbv) to immunize every newborn was initiated in taiwan in 1986. a serologic survey of 1,812 fully vaccinated children residing in four aboriginal villages and four adjacent nonaboriginal han chinese rural villages was conducted in 1993. children in three of the four aboriginal villages had significantly lower titers of antibody against hepatitis b surface antigen (anti-hbs) than did children in the nonaboriginal villages. evaluation of co ... | 1996 | 8651234 |
| a program for eradication of hepatitis b from taiwan by a 10-year, four-dose vaccination program. | approximately 15 percent of the taiwanese population are chronic carriers of hepatitis b virus (hbv), among the highest rates in asia. in july 1984, the taiwanese government initiated a nationwide hbv-vaccination program. the program began with educational efforts and voluntary prenatal screening for hbsag. infants of hbsag-carrier mothers received a four-dose regimen of hepatitis b vaccine. those born to highly infectious mothers also received a dose of hepatitis-b immune globulin within 24 hou ... | 1996 | 8734823 |