| immunodeficiency to hepatitis b virus infection and genetic susceptibility to development of hepatocellular carcinoma. | the high frequency of hepatitis b antigen (hbsag) in hepatocellular carcinoma (hcc) patients has led to the hypothesis that immunoresponsiveness to hepatitis b virus (hbv) may be deficient in some patients, and that the immune response deficiency may have a genetic basis. radioelectrocomplexing (rec), a radioimmunoassay in gel based on the principle of counterimmunoelectrophoresis (cie), has been used to identify four hbv immune status subgroups: 1) hbsag +ve/hbsab +ve; 2) hbsag +ve/hbsab -ve; 3 ... | 1975 | 173228 |
| incidence and etiology of primary liver cancer in the pacific basin. | the incidence of plc in the pacific basin varies from 0.9/100,000 (age-standardized) in women in new south wales, australia, to 34.2/100,000 in singapore chinese men. proportional incidence data suggest that other areas of the pacific basin, such as hong kong, taiwan, indonesia, and papua new guinea, may have plc incidence rates as high or higher than those in singapore chinese. infection with hepatitis-b virus has been associated with plc in some areas, and aflatoxin contamination of food has a ... | 1979 | 537620 |
| comparison of the immune response of four different dosages of a yeast-recombinant hepatitis b vaccine in singapore children: a four-year follow-up study. | the immunogenicity of four different dosages of yeast-derived hepatitis b vaccine (merck, sharp & dohme: 0.6 micrograms, 1.25 micrograms, 2.5 micrograms and 5.0 micrograms), administered at 0, 1 and 6 months (0-1-6 schedule) intramuscularly, was evaluated in 122 seronegative healthy children 1-12 years of age. three months after the first dose, 83.9-100% of the vaccinees seroconverted. peak geometric mean titres (gmt) of between 1088 mlu/ml and 1699 mlu/ml were attained 3 months after completion ... | 1992 | 1600584 |
| horizontal or vertical transmission of hepatitis b virus? a serological survey in family members of hepatitis b carriers in singapore. | hepatitis b serology was performed on 270 family members of 78 hepatitis b carriers and hepatitis b e antigen status determined in those found to be hbsag positive. the mean age of index patients was 38 years (range 3-74) and that of family members was 28 years (range 1-71). 67 family members (25%) were hbsag positive. the proportions of family members positive for hbsag and those negative for hbsag but positive for anti-hbs and/or anti-hbc were 25% and 20% for children, 10% and 68% for spouses, ... | 1991 | 1781002 |
| chronic hepatitis b infection in singapore. | four hundred and four patients (273 men, 131 women) aged 3 to 85 years with chronic hepatitis b virus (hbv) infection seen during a five year period were analysed. at presentation, 177 patients (44%) were hepatitis b e antigen (hbeag) positive (mean age 32 years) and 217 patients (54%) were anti-hbe-positive (mean age 40 years). ten patients (2%) were negative for hbeag and anti-hbe. serum hbv-dna was detected in 169 patients (42%). 85% of the hbeag-positive patients had detectable serum hbv-dna ... | 1991 | 1793464 |
| hepatocyte hepatitis b surface antigen expression in chronic hepatitis b virus carriers in singapore: correlation with viral replication and liver pathology. | the hepatocyte hepatitis b surface antigen (hbsag) expression in 149 liver biopsies from 124 chronic hepatitis b virus (hbv) carriers was correlated with serum hbv dna status and histologic activity. hepatocyte hbsag was stained by the peroxidase-antiperoxidase method and serum hbv dna was determined by dot blot hybridization. sixty-five biopsies (44%) showed minimal changes (mc), 82 biopsies (55%) showed chronic liver disease (cld) and 2 biopsies (1%) showed hepatocellular carcinoma. hepatocyte ... | 1991 | 1932667 |
| awareness and acceptance of hepatitis b vaccination in clementi, singapore. | hepatitis b virus infection, a public health problem in singapore, can be effectively controlled by vaccination. this paper reports on a study conducted in 1988/89 to ascertain the awareness and uptake rate of hepatitis b vaccination. a list of children born between november 1986 and may 1987 in the catchmen zone of the clementi maternal and child health (mch) clinic was obtained. out of a total of 257 children, 226 (87.9%) responded to our study in may 1988 which was part of a larger community ... | 1990 | 2151840 |
| hepatitis b vaccination in chronic renal failure patients undergoing haemodialysis: the immunogenicity of an increased dose of a recombinant dna hepatitis b vaccine. | thirty-two patients with end stage renal failure who were on haemodialysis and who had no previous exposure to hepatitis b virus were given four intramuscular injections of 40 micrograms (twice the recommended dose) recombinant dna hepatitis b vaccine (engerix b, smith kline biologicals) at 0, 1, 2 and 6 months to determine the immunogenicity of this increased vaccine dose. the ages of these patients ranged from 23-54 years with a mean age of 40 years. there were 11 males and 21 females. three p ... | 1990 | 2151841 |
| the hepatitis b immunization programme in singapore. | a voluntary immunization programme to prevent perinatal transmission of hepatitis b virus (hbv) infection in singapore was implemented on 1 october 1985 as an integral component of the national childhood immunization programme. up to april 1988, a total of 68,845 mothers who attended government maternal and child health clinics were screened for the disease. of these, 2432 (3.5%) were positive for hepatitis b surface antigen (hbsag) and 904 (1.3%) for hepatitis b e antigen (hbeag). virtually all ... | 1989 | 2523251 |
| the prevalence of hepatitis b virus markers in dental personnel in singapore. | a seroepidemiological survey of the prevalence of hepatitis b virus (hbv) markers was conducted in a group of 693 dental personnel in singapore where hbv infection is endemic. the overall prevalence of hbsag (4.5%) and anti-hbc (29%) was no higher than that in the general population. however, dentists had a significantly higher hbsag prevalence (11.4%) compared with that in the general population (4.2%) (p less than 0.01) and of other categories of dental personnel (3.1%) (p less than 0.001). si ... | 1988 | 3256997 |
| influenza surveillance in singapore: 1972-86. | prospective laboratory surveillance of influenza viruses has been carried out since 1973 in singapore. the results indicate that antigenic shift variants caused epidemics at various times of the year over this period, whereas drift variants were associated with a regular increase in incidence during the second and fourth calendar quarters. outbreaks due to influenza a virus occurred every year and to influenza b virus at intervals of 16-24 months. between outbreaks, viruses belonging to either o ... | 1988 | 3260142 |
| hepatitis b virus markers in prostitutes in singapore. | the prevalence of hepatitis b virus markers in 121 men and 239 women prostitutes was studied. of 33 (9.7%) with hepatitis b surface antigen (hbsag), nine (27.3%) also had hepatitis be antigen, which was more prevalent in men than women. antibodies to hbsag (anti-hbs) and to hepatitis b core antigen (anti-hbc) were found in about 71% of men and women prostitutes. hepatitis b virus markers were more prevalent in men than in women prostitutes. compared with other people, prostitutes had a significa ... | 1985 | 3980022 |
| maternal-child hepatitis b virus transmission in singapore. | a study of maternal-infant transmission of hepatitis b virus (hbv) was conducted in singapore between june 1980 and june 1982. hbsag carrier rate was highest among chinese (6.2%) followed by malay (2.3%) and indian (0.6%) mothers. the presence of hbeag in maternal sera correlated well with high titre hbsag (p = 7.34 x 10(-5)). overall hbv transmission occurred in 27/56 (48.2%) infants from carrier mothers. the majority of the transmission was perinatal. there was a very strong correlation betwee ... | 1985 | 3988432 |
| coxsackie b virus infection in singapore children. | | 1985 | 4009785 |
| hepatitis b virus and alphafetoprotein in liver diseases in singapore. | | 1980 | 6156492 |
| the immune status of singapore children to hepatitis b virus. | in a cross-sectional survey of hepatitis b immune status, 458 consecutive children below the age of 12 years were studied. 37.3% of these children were positive for one of three markers, hbsag, anti-hbs or anti-hbc. 15.5% were positive for two and 1.3% were positive for all three. 10.9% were positive for hbsag, 27.8% for anti-hbc and 19.6% for anti-hb2. the males showed a higher hbsag carrier rate than the females, 13.5% and 6.8% respectively. this difference was significant (p less than 0.05). ... | 1983 | 6605143 |
| immune status of various populations to hepatitis b virus in singapore and a strategy for its prevention and immunoprophylaxis. | | 1983 | 6653887 |
| chronic hepatitis in singapore. | about two thirds of chinese patients with chronic hepatitis were found to be associated with hepatitis b virus infection as reflected by hbsag (ria) and nearly all patients have been exposed to the virus as reflected by presence of anti-hbcag. both subdivisions of chronic hepatitis, chronic active and chronic persistent hepatitis were equally associated with hbv. auto-antibodies were observed in 2/24 (8%) patients. both patients were female and had chronic active hepatitis. the presence of hbeag ... | 1980 | 7425528 |
| molecular epidemiology of hepatitis b virus vaccine variants in singapore. | perinatal infection with variants of hepatitis b virus occurs despite combined immunoprophylaxis with hepatitis b immunoglobulin and currently licensed plasma-derived and recombinant yeast hepatitis b vaccines. several variants have been detected during a large study of infants born to carrier mothers in singapore. the most frequent variant was a virus in which a single amino acid substitution gly to arg occurred at amino acid position 145 of the outer protein coat of the virus. similar mutation ... | 1995 | 7483783 |
| prevalence of hepatitis b virus (hbv) infection in singapore men with sexually transmitted diseases and hiv infection: role of sexual transmission in a city state with intermediate hbv endemicity. | to describe the prevalence of hepatitis b virus (hbv) infection in patients with sexually transmitted diseases (std) and human immunodeficiency virus (hiv) infection, and to determine the role of sexual transmission of hbv infection in singapore. | 1995 | 7629470 |
| aflatoxin exposure in singapore: blood aflatoxin levels in normal subjects, hepatitis b virus carriers and primary hepatocellular carcinoma patients. | blood screening conducted on singaporeans over 1991-1992 showed exposure to predominantly aflatoxin b1 and to a lesser extent g1. the extent of exposure to b1 among three groups of residents in singapore, namely normal subjects (n = 423), hepatitis b virus carriers (n = 302) and primary hepatocellular carcinoma (phc) patients (n = 58) were extensive as reflected by the positive rates of 15.1, 0.7 and 1.7 per cent respectively. however, the degree of individual exposure to this toxin among the th ... | 1994 | 7830511 |
| seroepidemiology of hepatitis a and hepatitis b virus infection in a gurkha community in singapore. | the overall prevalence of hepatitis a virus (hav) infection among the gurkhas and their families stationed in singapore was 83.2%, with antibody to hav detected in 67 (38.1%) of 176 children under 5 years of age, 121 (76.6%) of 158 children between 5 and 14 years, and 600 (97.9%) of 613 older children and adults over age 15 years. children born in singapore (102/223 or 45.7%) had a significantly lower crude prevalence than those born in nepal (85/110 or 77.3%) (p < 0.000001). the age-adjusted di ... | 1993 | 8283176 |
| hepatitis b virus infection in singapore. | although singapore is in an endemic region for hepatitis b infection, the hepatitis b carriage rate of 5-6% is relatively low. the highest positivity rates for hepatitis b surface antigen (hbsag) are found in the paediatric age group, with another peak in 40-49 year olds. studies suggest that, although perinatal transmission is an important route of infection, most children acquire the virus through horizontal transmission between family members. viral replication continues at a high rate in you ... | 1996 | 8786046 |
| prevention and control of hepatitis b virus infection in singapore. | hepatitis b virus (hbv) accounted for 24% to 54% of the reported acute viral hepatitis cases in singapore from 1982 to 1996. the prevalence of hbv infection, as indicated by the presence of markers of hbv, increased from 9.3% in children below 5 years of age to 54.6% in adults above 55 years. the overall hepatitis b surface antigen (hbsag) prevalence was 5.7% for males and 3.4% for females, with the highest rate among the chinese. about 39% of the hbsag carriers were hepatitis b 'e' antigen posi ... | 1997 | 9494677 |
| identification of hepatitis b surface antigen variants with alterations outside the "a" determinant in immunized singapore infants. | vaccine-associated hepatitis b surface antigen (hbsag) mutations have been mainly identified within the "a" determinant (aa 124-147). now changes have been detected that are located outside the "a" determinant from immunized singapore infants born to hepatitis b virus (hbv) carrier mothers. these include asn116 to thr116, val118 to ala118, pro120 to ser120, ala159 to val159, phe183 to cys183, and val184 to ala184. decreased binding to "a" determinant-specific monoclonal antibody was observed for ... | 1999 | 9841851 |
| hepatitis b virus surface antigen (hbsag) mutants in singapore adults and vaccinated children with high anti-hepatitis b virus antibody levels but negative for hbsag. | | 2000 | 10979749 |
| mutations and deletions in core promoter and precore stop codon in relation to viral replication and liver damage in singaporean hepatitis b virus carriers. | the core promoter of hepatitis b virus (hbv) is crucial for the viral replication and mutations may lead to the establishment of chronic infection and development of liver diseases. we analysed this region in singaporean hbv carriers and assessed their association with viral replication and liver damage. | 2000 | 10998078 |
| frequent occurrence of hepatitis b virus surface antigen mutants in subtype adw in vaccinated singapore infants. | | 2001 | 11738727 |
| hepatitis b seroprevalence study 1999. | hepatitis b is a disease of public health importance in singapore. a study was conducted in 1999 to estimate the overall and gender-, age- and ethnic-specific prevalence of hepatitis b surface antigen (hbsag), hepatitis b e antigen (hbeag) and antibody to hepatitis b surface antigen in the singapore population. a cross-sectional sample of the singapore population constituting 4,698 singapore residents aged 18-69 years was surveyed. this was the first time a large-scale study has been conducted t ... | 2001 | 11811609 |
| pre-s deletion mutants co-exist with wild-type virus at low viral replication stage in singapore chronic hepatitis b virus carriers. | | 2002 | 11815861 |
| hepatitis b virus surface antigen mutants persist in chronic carriers receiving lamivudine therapy in singapore. | | 2002 | 12039904 |
| molecular characterization of hepatitis b virus surface antigen mutants in singapore patients with hepatocellular carcinoma and hepatitis b virus carriers negative for hbsag but positive for anti-hbs and anti-hbc. | mutations on the a-determinant of hepatitis b virus surface antigen (hbsag), capable of escaping detection and vaccination, are identified in hbsag-positive/anti-hbs-positive vaccinated infants. we studied the prevalence of these mutants in hbsag-negative/anti-hbc-positive chronic hbv carriers and patients with hepatocellular carcinoma (hcc). | 2002 | 12534784 |
| the majority of hepatitis b carriers are not on regular surveillance in singapore. | carriers of hepatitis b virus (hbv) are at risk of developing long-term complications. regular surveillance helps detect treatable chronic hepatitis, cirrhosis and liver cancer, and is recommended by practice guidelines in the united states, europe and singapore. however, there have been few studies evaluating the follow-up of hbv carriers. this study seeks to determine the proportion of hbv carriers on regular follow-up in singapore and the impact on hepatitis b disease. | 2004 | 15334285 |
| a cost comparison of management of chronic hepatitis b and its associated complications in hong kong and singapore. | to estimate and compare the direct medical cost in the management of chronic hepatitis b (chb) infection and its complications from the perspective of public health organizations in hong kong and singapore. | 2004 | 15602161 |
| characterization of mutations in crf01_ae virus isolates from antiretroviral treatment-naive and -experienced patients in singapore. | to determine the frequency of drug resistance mutations among antiretroviral treatment-naive and -experienced patients infected with crf01_ae virus. | 2005 | 15608517 |
| what barriers do primary care physicians face in the management of patients with chronic hepatitis b infection in primary care? | asymptomatic chronic hepatitis b virus (hbv) carriers, followed-up in primary care, present a challenge to primary care physicians as they encounter problems in monitoring this group of patients. the study aims to explore the barriers faced by primary care physicians in the management of patients with chronic hepatitis b infection in primary care. | 2005 | 15968445 |
| adult living donor liver transplantation in singapore: the asian centre for liver diseases and transplantation experience. | living donor liver transplantation (ldlt) has progressed dramatically in asia due to the scarcity of cadaver donors and is increasingly performed in singapore. the authors present their experience with adult ldlt. | 2007 | 17767331 |
| public misperceptions about transmission of hepatitis b virus in singapore. | hepatitis b virus (hbv) infection is endemic in asia. good public knowledge on disease transmission is one way of controlling spread of hbv. we aimed to study the general knowledge on hbv among the general public in singapore, which is moderately prevalent with hbv. | 2007 | 17987228 |
| primary vaccination of infants against hepatitis b can be completed using a combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis b-inactivated poliomyelitis-haemophilus influenzae type b vaccine. | children in singapore receive vaccination against hepatitis b virus (hbv) at 0, 1 and 5 or 6 months of age, and vaccination against pertussis, diphtheria, tetanus, and polio at 3, 4 and 5 months of age. parents often choose to vaccinate with the combined acellular-pertussis-inactivated polio-hib vaccine (dtpa-ipv/hib). we investigated whether a combined hexavalent vaccine, dtpa-hbv-ipv/hib, could replace the separate administration of dtpa-ipv/hib and hbv for the final vaccination at 5 months of ... | 2007 | 17987229 |
| understanding the immunopathogenesis of chronic hepatitis b virus: an asian prospective. | the study of hepatitis b virus (hbv) immunity has been mainly focused on understanding the differences between subjects who are able to control hbv infection and patients with persistent infection. these studies have been instrumental in increasing our knowledge on the pathogenesis of the disease caused by hbv. however, it is possible that heterogeneity of host and virus factors which segregate in ethnically distinct hbv infected populations might modify important aspects of the immune response ... | 2008 | 18565018 |
| how big is the financial burden of hepatitis b to society? a cost-of-illness study of hepatitis b infection in singapore. | hepatitis b virus (hbv) infection is the most common cause of chronic viral liver disease in singapore. nevertheless, very little data exist on the financial burden of hbv infection to the society as a whole. the aim of this study was therefore to assess the direct and indirect cost of hbv infection in a cost-of-illness analysis. the combined data from the direct and indirect cost with the estimated prevalence for different disease stages of hbv infection would represent the annual financial bur ... | 2009 | 19192158 |
| cultural adaptation and validation of a questionnaire for use in hepatitis b patients. | health-related quality of life (hrqol) is an important aspect of the overall management of hepatitis b virus (hbv) infection. the major challenge is to find a valid and reliable disease-specific hrqol instrument designed specifically for measuring health status in hepatitis b patient. consequently, this study was undertaken to adapt culturally the hepatitis quality of life questionnaire (hqlq) and assess its suitability for use in english-speaking hepatitis b virus-infected (hbv) patients in sin ... | 2009 | 19200131 |
| reliability and validity of a chinese version's health-related quality of life questionnaire for hepatitis b patients. | to culturally adapt a chinese version of the hepatitis quality of life questionnaire (hqlq) and assess its suitability for use in chinese-speaking hepatitis b virus (hbv patients in singapore. | 2010 | 19804432 |
| viral agents responsible for febrile respiratory illnesses among military recruits training in tropical singapore. | military personnel are highly susceptible to febrile respiratory illnesses (fri), likely due to crowding, stress and other risk factors present in the military environment. | 2010 | 20079688 |
| comparison of the technical and clinical performance of the elecsys hbsag ii assay with the architect, axsym, and advia centaur hbsag screening assays. | south east asia has some of the highest prevalence rates of hepatitis b virus (hbv) infection (>or=8%) in the world, and the emergence of hepatitis b surface antigen (hbsag) mutant strains is a growing problem. assays with the highest levels of sensitivity, including mutant detection, should be used for routine hbsag screening. in this large multicenter study, the clinical and technical performance of the fully automated elecsys hbsag ii assay was compared with the architect, axsym, and advia ce ... | 2010 | 20336717 |
| the asia-pacific consensus on ulcerative colitis. | inflammatory bowel disease (ibd) is increasing in many parts of the asia-pacific region. there is a need to improve the awareness of ibd and develop diagnostic and management recommendations relevant to the region. this evidence-based consensus focuses on the definition, epidemiology and management of ulcerative colitis (uc) in asia. a multi-disciplinary group developed the consensus statements, reviewed the relevant literature, and voted on them anonymously using the delphi method. the finalize ... | 2010 | 20370724 |
| changing seroprevalence of hepatitis b virus markers of adults in singapore. | we presented the findings from 2 seroprevalence studies conducted 6 years apart, so as to determine changes in the hepatitis b surface antigen (hbsag) positivity rate and immunity to hepatitis b virus (hbv) among singapore residents aged 18 to 69 years, and to assess the impact of a 4-year catch-up hepatitis b immunisation programme for adolescents and young adults launched in 2001. | 2010 | 20838699 |
| risk of hepatitis b virus (hbv) reactivation in hepatitis b surface antigen negative/hepatitis b core antibody positive patients receiving rituximab-containing combination chemotherapy without routine antiviral prophylaxis. | the use of rituximab has been associated with increased risk of hepatitis b virus (hbv) reactivation in patients who are hepatitis b surface antigen (hbsag) negative and antihepatitis b core antibody (anti-hbc) positive. we aim to determine the rate of hbv reactivation in this group of patients who received rituximab-containing combination chemotherapy without concomitant antiviral prophylaxis and to identify potential risk factors for reactivation. sixty-two hbsag negative/anti-hbc positive pat ... | 2011 | 21520001 |
| missed diagnosis of influenza b virus due to nucleoprotein sequence mutations, singapore, april 2011. | a new influenza b variant was discovered in singapore in april 2011 during diagnostic testing of a 3-year-old boy with respiratory symptoms. influenza b virus was isolated from culture and confirmed by standard immunofluorescence testing, but was not detected by the routine, in-house influenza screening reverse-transcription polymerase chain reaction assay that targets the nucleoprotein (np) gene. subsequent sequencing investigations demonstrated that several other published assays targeting np ... | 2011 | 21871229 |
| ten years of dengue drug discovery: progress and prospects. | to combat neglected diseases, the novartis institute of tropical diseases (nitd) was founded in 2002 through private-public funding from novartis and the singapore economic development board. one of nitd's missions is to develop antivirals for dengue virus (denv), the most prevalent mosquito-borne viral pathogen. neither vaccine nor antiviral is currently available for denv. here we review the progress in dengue drug discovery made at nitd as well as the major discoveries made by academia and ot ... | 2013 | 24076358 |
| defining cd8+ t cell determinants during human viral infection in populations of asian ethnicity. | the identification of virus-specific cd8(+) t cell determinants is a fundamental requirement for our understanding of viral disease pathogenesis. t cell epitope mapping strategies increasingly rely on algorithms that predict the binding of peptides to mhc molecules. there is, however, little information on the reliability of predictive algorithms in the context of human populations, in particular, for those expressing hla class i molecules for which there are limited experimental data available. ... | 2013 | 24058176 |
| surveillance and clinical characterization of influenza in a university cohort in singapore. | southeast asia is a potential locus for the emergence of novel influenza strains. however, information on influenza within the region is limited. | 2015 | 25790305 |
| prospective surveillance and molecular characterization of seasonal influenza in a university cohort in singapore. | southeast asia is believed to be a potential locus for the emergence of novel influenza strains, and therefore accurate sentinel surveillance in the region is critical. limited information exists on sentinel surveillance of influenza-like illness (ili) in young adults in singapore in a university campus setting. the objective of the present study was to determine the proportion of ili caused by influenza a and b viruses in a university cohort in singapore. | 2014 | 24520371 |
| the transcriptomic g1-g6 signature of hepatocellular carcinoma in an asian population: association of g3 with microvascular invasion. | in this study, a transcriptomic group classification based on a european population is tested on a singapore cohort. the results highlight the genotype/phenotype correlation in a southeast asian population. the g1-g6 transcriptomic classification derived from hepatocellular carcinoma (hcc) resected from european patients, robustly reflected group-specific clinical/pathological features. we investigated the application of this molecular classification in southeast asian hcc patients.gene expressi ... | 2016 | 27893662 |
| dietary fatty acids and risk of hepatocellular carcinoma in the singapore chinese health study. | lipidomic signature of lipid metabolism suggests that omega-6 polyunsaturated fatty acids (pufa) may play a role in oncogenesis of hepatocellular carcinoma (hcc). hence, we examined the association between dietary fatty acids and risk of hcc. | 2016 | 26443688 |
| rates of cirrhosis and hepatocellular carcinoma in chronic hepatitis b and the role of surveillance: a 10-year follow-up of 673 patients. | development of cirrhosis and hepatocellular carcinoma (hcc) are critical milestones in the natural history of chronic hepatitis b virus (hbv) infection. there are no prospective data on the risk of these critical milestones in hbv patients in singapore. the efficacy and justification of hcc surveillance is determined by the rate of hcc development. our study aims to determine the rates of cirrhosis and hcc in hbv patients in singapore and hence the appropriateness of hcc surveillance. | 2015 | 25831135 |
| hepatitis b immunoprophylaxis failure and the presence of hepatitis b surface gene mutants in the affected children. | hepatitis b virus (hbv) infection is usually vertically transmitted from the mother to child during birth in asian countries. despite immunization, immunoprophylaxis failure is well-documented. the aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chronic hbv-infected mothers and to determine risk factors for failure. this was an observational study involving chronic hepatitis b infected mothers seen at a tertiary care center in singapore between ... | 2015 | 25782362 |
| immunoprevalence and immunodominance of hla-cw*0801-restricted t cell response targeting the hepatitis b virus envelope transmembrane region. | hla-c-restricted t cells have been shown to play an important role in hiv control, but their impact on protection or pathogenesis in other viral infections remains elusive. here, we characterized the hierarchy of hla class i-restricted hepatitis b virus (hbv) epitopes targeted by cd8 t cells in hbv-infected subjects. the frequency of cd8 t cells specific for a panel of 18 hbv epitopes (restricted by hla-a∗0201/03/07 [hereinafter hla-a0201/03/07], -a1101, -a2402/07, -b5801, -b4001, -b1301, and -c ... | 2014 | 24227846 |
| seroepidemiology of hepatitis b virus infection among adults in singapore: a 12-year review. | we undertook a national hepatitis b seroprevalence study to assess the seroprevalence of hepatitis b virus (hbv) markers in the adult population in singapore in 2010 and make comparisons with the seroprevalence in 1998 and 2004. the study involved residual sera from national health surveys conducted every six years since 1998. the tests for hbv markers were carried out using commercial chemiluminescent microparticle immunoassay. in 2010, the prevalence of hepatitis b surface antigen (hbsag) amon ... | 2013 | 24200974 |
| seroprevalence of hepatitis b virus infection among children and adolescents in singapore, 2008-2010. | a national pediatric survey was undertaken to determine the prevalence of hepatitis b virus markers in singapore. the aim was to assess the impact of the national childhood immunization program against hepatitis b implemented for all newborns since 1987. the survey involved prospective collection of residual sera from singapore residents aged 1-17 years attending inpatient services or day surgery in two public hospitals between august 2008 and july 2010. a total of 1,200 sera were collected comp ... | 2013 | 23400872 |
| genetic characterisation of influenza b viruses detected in singapore, 2004 to 2009. | influenza b viruses are classified into two main lineages: yamagata-like and victoria-like, which differ antigenically and phylogenetically. to understand the evolution of influenza b viruses in south east asia as well as to determine the vaccine efficacy, we genetically characterised gene segments 4, 6 and 8 from non-tissue culture adapted influenza b viruses detected in singapore from 2004 to 2009. | 2014 | 25435177 |