| development and efficacy of novobiocin and rifampicin-resistant aeromonas hydrophila as novel vaccines in channel catfish and nile tilapia. | three attenuated aeromonas hydrophila vaccines were developed from the virulent 2009 west alabama isolates through selection for resistance to both novobiocin and rifampicin. when channel catfish (ictalurus punctatus) were ip injected with 4×105 colony-forming unit (cfu) of the mutants, no fish died. however, when the same age and size matched channel catfish were ip injected with similar amount of their virulent parents, 80-100% fish died. similarly, when nile tilapia (oreochromis niloticus) we ... | 2011 | 21872628 |