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heterogeneity in levels of serum neutralizing antibodies against viral hemorrhagic septicemia virus genotype ivb among fish species in lake st. clair, michigan, usa.the presence of neutralizing antibodies against viral hemorrhagic septicemia virus (vhsv-ivb) was investigated in sera of 13 fish species collected from lake st. clair, michigan, usa, a vhsv-endemic water body. we tested 297 sera collected may 2004-june of 2010, using a complement-dependent 50% plaque neutralization test (50% pnt). neutralizing antibodies were detected in 23% (67/297) of the samples. the highest overall antibody prevalence (85%, 34/40) and mean positive antibody titer (12,113 ± ...201222493115
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