| chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). | principles of concentration addition and independent action have been used as effective tools to predict mixture toxicity based on individual component toxicity. the authors investigated the toxicity of a pharmaceutical mixture composed of the top 10 detected active pharmaceutical ingredients (apis) in the tama river (tokyo, japan) in a relevant concentration ratio. both individual and mixture toxicities of the 10 apis were evaluated by 3 short-term chronic toxicity tests using the alga pseudoki ... | 2016 | 26472177 |