| apolipoprotein e variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. | three common protein isoforms of apolipoprotein e (apoe), encoded by the epsilon2, epsilon3, and epsilon4 alleles of the apoe gene, differ in their association with cardiovascular and alzheimer's disease risk. to gain a better understanding of the genetic variation underlying this important polymorphism, we identified sequence haplotype variation in 5.5 kb of genomic dna encompassing the whole of the apoe locus and adjoining flanking regions in 96 individuals from four populations: blacks from j ... | 2000 | 10986041 |