Publications
| codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the tibet plateau. | mutational changes in p53 correlate well with tumorigenesis. remarkably, however, relatively little is known about the role that p53 variations may play in environmental adaptation. here we report that codon asparagine-104 (104n) and glutamic acid-104 (104e), respectively, of the p53 gene in the wild zokor (myospalax baileyi) and root vole (microtus oeconomus) are adaptively variable, meeting the environmental stresses of the tibetan plateau. they differ from serine-104 (104s) seen in other rode ... | 2013 | 24297887 |
| distinct post-transcriptional regulation of igfbp1 gene by hypoxia in lowland mouse and qinghai-tibet plateau root vole microtus oeconomus. | our previous study revealed the particular expression patterns of insulin-like growth factor 1 (igf1) and insulin-like growth factor binding protein 1 (igfbp1) in the qinghai-tibet plateau root vole (microtus oeconomus) under hypoxic challenge. here we report the molecular mechanisms of igf gene regulation associated with adaptation to hypoxia. m. oeconomus igf1 and igfbp1 were shown to be highly conserved. hypoxia (8.0% o2, 6h) did not change the liver-derived igf1 expression in either m. oecon ... | 2013 | 23748030 |