Publications

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properties and dissemination of h5n1 viruses isolated during an influenza outbreak in migratory waterfowl in western china.h5n1 influenza a viruses are widely distributed among poultry in asia, but until recently, only a limited number of wild birds were affected. during late april through june 2005, an outbreak of h5n1 virus infection occurred among wild birds at qinghai lake in china. here, we describe the features of this outbreak. first identified in bar-headed geese, the disease soon spread to other avian species populating the lake. sequence analysis of 15 viruses representing six avian species and collected a ...200616731936
characterization of a highly pathogenic h5n1 influenza virus derived from bar-headed geese in china.influenza a viruses are usually non-pathogenic in wild aquatic birds, their natural reservoir. however, from may to july 2005, at qinghai lake in china, an unprecedented outbreak of highly pathogenic h5n1 avian influenza virus caused the death of thousands of wild migratory waterbirds. herein, h5n1 influenza virus from bar-headed geese collected during the outbreak was characterized. genomic analysis showed that a/bar-headed goose/qinghai/0510/05 (bh h5n1 virus) is a reassortant virus. amino aci ...200616760384
protective efficacy of the h5 inactivated vaccine against different highly pathogenic h5n1 avian influenza viruses isolated in china and vietnam.an inactivated h5n1 avian influenza (ai) vaccine generated by reverse genetics and containing the hemagglutinin and neuraminidase genes of the h5n1 a/goose/guangdong/1/96 (gs/gd/06) virus has been used in domestic poultry in china and vietnam as an important control strategy for h5n1 ai. the efficacy of this vaccine against early h5n1 isolates has been fully evaluated in chicken, ducks, and geese. however, there are no reports about its efficacy against h5n1 viruses recently isolated in china an ...201020521646
flying over an infected landscape: distribution of highly pathogenic avian influenza h5n1 risk in south asia and satellite tracking of wild waterfowl.highly pathogenic avian influenza (hpai) h5n1 virus persists in asia, posing a threat to poultry, wild birds, and humans. previous work in southeast asia demonstrated that hpai h5n1 risk is related to domestic ducks and people. other studies discussed the role of migratory birds in the long distance spread of hpai h5n1. however, the interplay between local persistence and long-distance dispersal has never been studied. we expand previous geospatial risk analysis to include south and southeast as ...201121267626
wild bird migration across the qinghai-tibetan plateau: a transmission route for highly pathogenic h5n1.qinghai lake in central china has been at the center of debate on whether wild birds play a role in circulation of highly pathogenic avian influenza virus h5n1. in 2005, an unprecedented epizootic at qinghai lake killed more than 6000 migratory birds including over 3000 bar-headed geese (anser indicus). h5n1 subsequently spread to europe and africa, and in following years has re-emerged in wild birds along the central asia flyway several times.201121408010
characterisation of a highly pathogenic h5n1 clade 2.3.2 influenza virus isolated from swans in shanghai, china.in spring 2009, one strain of h5n1 clade 2.3.2 virus was isolated from wild swans in shanghai, indicating the importance of the wild swan in the ecology of this highly pathogenic avian influenza virus (hpaiv) in eastern china. pathogenicity experiments conducted in this study indicated that the virus was highly pathogenic for chickens but lowly pathogenic for mammalian hosts, as evidenced by reduced infection of mice. the analysis of complete genome sequences and genetic evolution showed that a/ ...201121904849
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