kinase inhibitory, haemolytic and cytotoxic activity of three deep-water sponges from north western australia and their fatty acid composition. | the c-amp dependent protein kinase (pka) inhibition, haemolytic activity, and cytoxicity of 21 extracts obtained from north western australian sponges collected from depths of 84-135 m were investigated. hexane extracts from ircinia/sarcotragus sp. and geodia sp. displayed pka inhibitory activities of 100 and 97% respectively (at 100 microg/ml), while aq. methanol extracts from haliclona sp. exhibited potent haemolytic activity (75%) and hexane extracts from geodia sp. were highly toxic (88%) to ... | 2011 | 22312740 |