| incidence of toxigenic vibrios in foods available in taiwan. | a total of 1088 vibrios and related species were isolated from seafood and aquacultured foods available in taiwan. they were identified as vibrio alginolyticus, v. cholerae, v. fluvialis i, v. fluvialis ii, v. parahaemolyticus, v. mimicus, aeromonas caviae, a. hydrophila, a. sobria and other species. incidence of these vibrio and aeromonas species in these foods was high. vibrio parahaemolyticus was frequently found in seawater and in foods of freshwater origin. the vibrio isolates were examined ... | 1992 | 1399913 |
| pesticide clastogenicity in chinese hamster ovary cells. | paraquat, alachlor, butachlor, phorate and monocrotophos, several of the most extensively used pesticides in taiwan, were investigated for their clastogenicity using chromosome aberration (cab) induction in chinese hamster ovary (cho) cells. significance levels of the binomial trend analysis and binomial mutagenicity data test were two criteria for the summary judgement of the pesticide clastogenicity. except for phorate, all pesticides tested were clastogenic to cho cells in the absence of in v ... | 1987 | 3600690 |
| effect of fermentation conditions on the enterotoxigenicity, cytotoxicity and pesticidal activity of bacillus thuringiensis strains isolated in taiwan. | a total of 75 bacillus thuringiensis strains, among them 62 of taiwan's microbiota, were screened for their enterotoxin genes, hemolysin bl activity and cytotoxicity. all the strains harbored enterotoxin genes and were cytotoxic to the cultivated chinese hamster ovary (cho) cells. the hemolysin bl and cytotoxicity titers of the b. thuringiensis culture in casitone yeast sucrose (cys) broth were lower than those in brain heart infusion (bhi) broth, and when the b. thuringiensis strains were culti ... | 2010 | 19880313 |
| colorectal cancer and genetic polymorphism of dna double-strand break repair gene xrcc4 in taiwan. | the dna repair gene x-ray repair complementing defective repair in chinese hamster cells 4 (xrcc4) is thought to play a major role in the caretaking of the whole genome via double-strand break repair. however, the association of polymorphic variants of xrcc4 with colorectal cancer susceptibility has never been reported. in this hospital-based case-control study, the association of xrcc4 polymorphisms c-1622t (rs7727691), g-1394t (rs6869366), g-652t (rs2075685), c-571t (rs2075686), intron 3 dip ( ... | 2010 | 20683005 |
| in vitro and in vivo safety of aqueous extracts of graptopetalum paraguayense e. walther. | ethnopharmacological relevance: graptopetalum paraguayense e. walther, a widely consumed vegetable in taiwan, has many biological effects and has been used in folk medicine to alleviate hepatic disorders, exert diuretic effects, and relieve pain and infections. however, little data exist regarding its safety. materials and methods: two genotoxicity assays were performed: chromosomal aberration of chinese hamster ovary (cho-k1 cells) (in vitro) and micronucleus assay in mice (in vivo). acute oral ... | 2012 | 22240512 |
| a novel scn9a mutation responsible for primary erythromelalgia and is resistant to the treatment of sodium channel blockers. | primary erythromelalgia (pe) is an autosomal dominant neurological disorder characterized by severe burning pain and erythema in the extremities upon heat stimuli or exercise. mutations in human scn9a gene, encoding the α-subunit of the voltage-gated sodium channel, na(v)1.7, were found to be responsible for pe. three missense mutations of scn9a gene have recently been identified in taiwanese patients including a familial (i136v) and two sporadic mutations (i848t, v1316a). v1316a is a novel muta ... | 2013 | 23383113 |
| association of dna double-strand break gene xrcc6 genotypes and lung cancer in taiwan. | the dna repair gene x-ray repair complementing defective repair in chinese hamster cells 6 (xrcc6) is thought to play an important role in the repair of dna double-strand breaks. it is known that defects in double-strand break repair capacity can lead to irreversible genomic instability. however, the association of polymorphic variants of xrcc6 with lung cancer susceptibility has never been reported. in this hospital-based case-control study, the association of xrcc6 promoter t-991c (rs5751129), ... | 2012 | 22399625 |
| functional characterisation of a complex mutation in the α(1,4)galactosyltransferase gene in taiwanese individuals with p phenotype. | individuals with p phenotype lack p1, p(k) and p antigens on red blood cells, presumably as a result of deficiency in the enzyme α(1,4)galactosyltransferase (a4galt). the aim of this study was to explore the molecular background of a taiwanese family with p phenotype. | 2011 | 21092013 |
| structural basis of citrate-dependent and heparan sulfate-mediated cell surface retention of cobra cardiotoxin a3. | anionic citrate is a major component of venom, but the role of venom citrate in toxicity other than its inhibitory effect on the cation-dependent action of venom toxins is poorly understood. by immobilizing chinese hamster ovary cells in microcapillary tubes and heparin on sensor chips, we demonstrated that heparan sulfate-mediated cell retention of the major cardiotoxin (ctx) from the taiwan cobra, ctx a3, near membrane surfaces is citrate-dependent. x-ray determination of a ctx a3-heparin hexa ... | 2005 | 15590643 |