| lmtk3 expression in breast cancer: association with tumor phenotype and clinical outcome. | interactions between kinases and the estrogen receptor ╬▒ (er╬▒) are thought to be a critical signaling pathway in the majority of human breast cancers. we have recently identified a previously uncharacterized molecule, lemur tyrosine kinase-3 (lmtk3) as a prognostic and predictive oncogenic er╬▒ regulator with a central role in endocrine resistance. unusually this protein has undergone darwinian positive selection between chimpanzees and humans suggesting it may contribute to human susceptibili ... | 2011 | 21671015 |