| tau as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of guam. | a guam variant of amyotrophic lateral sclerosis (als-g) and parkinsonism dementia complex (pdc-g) are found in the chamorro people of guam. both disorders have overlapping neuropathologic findings, with neurofibrillary tangles in spinal cord and brain. the cause of als-g-pdc-g is unknown, although inheritance and environment appear important. because neurofibrillary tangles containing tau protein are present in als-g-pdc-g, and because mutations in the tau gene (tau) cause autosomal dominant fro ... | 2001 | 11708997 |