[potential filaricides. suramin analogs].a series of suramin analogues has been synthesized in which the methyl groups of suramin have been replaced by hydrogen, alkyl, phenyl, and fluoro substituents, or which contain more than two methyl groups. the substances have been screened against dipetalonema viteae in meriones unguiculatus, litomosoides carinii in sigmodon hispidus and l. carinii in mastomys natalensis, respectively. small structural modifications have a marked influence on the antifilarial activity. there are marked differen ...19863778551
studies of potential filaricides: part 14--activity of 1-iso-butoxycarbonyl-4-methylpiperazine against experimental filariasis.the synthesis and filaricidal activity of 1-iso-butoxycarbonyl-4-methylpiperazine against litomosoides carinii in sigmodon hispidus and dipetalonema viteae in mastomys natalensis is reported. at an intraperitoneal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariae but had no effect on adult l. carinii. however, it killed all microfilariae and adults of d. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. the compound also possessed chemo ...19846542118
antifilarial activity of some 2h-1-benzopyran-2-ones (coumarins).six synthetic 2h-1-benzopyran-2-one (cournarin) derivatives (cdri compounds # 1, 2, 3, 4, 5 and 6) were evaluated for filaricidal activity against litomosoides carinii and acanthocheilonema viteae infections in cotton rats (sigmodon hispidus) and mastomys coucha respectively. significant effects on macrofilariae (>80% death/sterilisation) were detected with compounds #2, 3 and 6 against l. carinii and/or a. viteae. thus detection of filaricidal activity in benzopyrones, which are so far known fo ...200010936568
antifilarial activity of a synthetic marine alkaloid, aplysinopsin (cdri compound 92/138).cdri compound 92/138, a synthetic analogue of aplysinopsin, was evaluated in experimental filarial infections, litomosoides carinii in cotton rats (sigmodon hispidus) and acanthocheilonema viteae in mastomys coucha. the compound killed 63.8 and 90% of adult l. carinii and a. viteae at doses of 30 and 50 mg/kg (i.p.) respectively given for 5 days. by the oral route, at 100 mg/kg for 5 days the compound caused 50.9 and 57% mortality of adult l. carinii and a. viteae, respectively. at 200 mg/kg adm ...19979236820
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