| igg response of rats to the excretory-secretory products of litomosoides carinii. | the nature of antibody responses to the excretory-secretory (es) products of adult worms and microfilariae (mf) of litomosoides carinii in albino rats and their possible role in protection have been studied. rats were immunized with es products derived from in vitro incubation of adults or mf. the sera from these rats promoted neutrophil-mediated killing of mf in vitro. the antibody responsible for the cytocidal activity was identified as igg isotype. indirect fluorescent antibody test showed th ... | 1990 | 2191288 |
| on the pathogenesis of anaemia and leukopenia in filarial (litomosoides carinii) infection of mastomys natalensis. | mastomys natalensis infected with the filarial parasite litomosoides carinii show anaemia and leukopenia. alterations start with the onset of microfilaraemia. anaemia is temporally macrocytic (up to 80 days after infection), subsequently normocytic and hypochromic, accompanied by reticulocytosis. increased intravascular haemolysis (i) and functional disorders of the haemopoetic system (ii) are involved in the pathogenesis. i: circulating erythrocytes showed increased osmofragility. hypoglycaemia ... | 1991 | 1853669 |
| [chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 5. alterations of haematological parameters after the administration of filaricidal compounds (author's transl)]. | the peripheral blood picture of multimammate rats (mastomys natalensis) infected with litomosoides carinii was studied. changes were followed in patent infections from 64 to 176 days after infection in animals treated with diethylcarbamazine (5 x 100 mg/kg per os), hoe 258 v (5 x 10 mg/kg subcutaneously), suramin (5 x 40 mg/kg subcutaneously) and with a combined treatment of diethylcarbamazine and suramin. in addition, haematological changes were followed in non-infected animals treated with sur ... | 1975 | 1096385 |
| fate of litomosoides carinii adults transplanted into the pleural or peritoneal cavity of infected and naive multimammate rats (mastomys natalensis). | in each of 4 experiments, 58 multimammate rats (mastomys natalensis) were subdivided into 5 groups. thirty-four rats were infected with litomosoides carinii and infections were allowed to become patent. ten days after patency adult worms were surgically transferred from donor rats to each of 1 group of infected rats and 1 group of naive rats. groups of infected and naive rats served as controls. transfers were made either intrapleurally or intraperitoneally. samples of blood and tissues were tak ... | 1976 | 1003278 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 7. filaricidal activity of furazolidone. | investigations were carried out on the filaricidal activity of furazolidone against litomosoides carinii infection in mastomys natalensis. oral administration of the drug in daily doses of 25, 50, 75, and 150 mg/kg body weight on 5 consecutive days revealed respectively 96,4, 99,3 and, with the two later doses, 100% reduction of macrofilariae in the pleural cavities, and produced a continuing dose-dependant decrease of microfilaraemia in the circulating blood. after oral doses of 5 x 50 mg/kg, a ... | 1978 | 675840 |
| effect of diethylcarbamazine on the microfilariae of litomosoides carinii in mastomys natalensis: dynamics of cell adhesion, immobilization and elimination of microfilariae. | | 1978 | 644656 |
| [simultaneous infection of mastomys natalensis with dipetalonema witei and litomosoides carinii (author's transl)]. | mastomys natalensis that has been described by lämmler et al. (1968) as suitable host for litomosoides carinii can also serve as final host for dipetalonema witei. at the end of the prepatency period the microfilaraemia increased as rapidly in mastomys as in the original final host meriones persicus. maximal microfilaraemia was observed earlier in mastomys (120 days p.inf.) than in meriones (250 days p.inf.). accordingly microfilariae counts decreased more rapidly in mastomys. the maximal counts ... | 1979 | 575582 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 8. the action of furazolidone on adult worms and microfilariae. | after oral administration of furazolidone in doses of 5 x 50 mg/kg and 1 x 100 mg/kg body weight to litomosoides carinii--infected mastomys natalensis microfilaraemia decreased continuously and was reduced by more than 98% 42 days after start of treatment. after the 5-day treatment all adult female and male worms were found dead and encapsulated within 2 weeks, whereas after the single dose 100% of the female parasites were encapsulated 28 days after treatment. in untreated animals quantiative e ... | 1979 | 543002 |
| litomosoides carinii: effect of splenectomy on the ability of naive mastomys natalensis to accept transplanted adults. | | 1978 | 680080 |
| morphological alterations in female litomosoides carinii after treatment with two benzthiazole derivatives in vivo. | multimammate rats (mastomys natalensis) infected with litomosoides carinii were treated 65 days after infection with a single oral dose of 50 mg/kg of cgp 20308 or cgp 20376 (ciba geigy limited, basel). autopsies were performed between 1 and 28 days after treatment. the numbers of worms and the numbers and condition of intrauterine developmental stages in the females were determined. other female filariae were investigated by transmission electron microscopy (tem). female filariae were observed ... | 1987 | 3602833 |
| histopathological and electron microscopical studies in litomosoides carinii infected mastomys natalensis. | | 1987 | 3591109 |
| reaginic and homocytotropic igg antibody response of mastomys natalensis in experimental infections of filarial parasites (litomosoides carinii, dipetalonema viteae, brugia malayi, b. pahangi). | reaginic and homocytotropic igg antibodies in sera using passive cutaneous anaphylaxis (pca) test and antigen from litomosoides carinii were followed in mastomys natalensis, infected with l. carinii, dipetalonema viteae, brugia malayi or b. pahangi. groups of animals with infections of various ages so as to cover a total infection period of up to 300 to 420 days post-infection (p.i.), depending on the species of parasites, were bled at 1- to 3-week intervals over periods of 50-112 days. in addit ... | 1987 | 3588585 |
| immunity to litomosoides carinii in mastomys natalensis. ii. effects of chemotherapeutically abbreviated and postpatent primary infections on challenges with various stages of the parasite. | naive mastomys natalensis, litomosoides carinii-infected m. natalensis at a postpatent stage of the infection and l. carinii-infected m. natalensis treated chemotherapeutically with furazolidone (fur), fur and diethylcarbamazine (fur/dec) or amoscanate (amos) were challenged by either injection or implantation of 40 third stage larvae (l3, s.c.), 40 fourth stage larvae (l4, 16 days old, i.p.), 20 male and 20 female preadult worms (36 days old, i.p.), 12 adult female worms (i.p.) or 6 x 10(6) mic ... | 1986 | 3541424 |
| detection of circulating and urinary antigens in mastomys natalensis experimentally infected with brugia malayi, brugia pahangi, or litomosoides carinii. | the time-course of the detection of circulating and urinary filarial antigens was followed with a 2s-irma assay, using a mouse monoclonal antibody raised against brugia malayi larvae, in mastomys natalensis experimentally infected with brugia malayi, brugia pahangi, or litomosoides carinii. in the prepatent phase of the infections, filarial antigen was detected 4-7 weeks before microfilariae appeared in the peripheral blood. moreover, the sensitivity of the test was greater with urine than with ... | 1987 | 3438300 |
| effect of cyclosporin a and some derivatives in litomosoides carinii-infected mastomys natalensis. | litomosoides carinii-infected mastomys natalensis were treated 85 days post infection with cyclosporin a (cya) or 8 derivatives with different immunosuppressive capacities. cya (oral doses of 5 x 25 mg/kg, 5 x 50 mg/kg, 5 x 80 mg/kg on consecutive days) reduced parasitaemia levels in a dose dependent way, beginning 3 weeks after first drug administration. using 5 x 50 and 5 x 80 mg/kg animals were free from circulating microfilariae on the day of necropsy (day 56). derivatives were administered ... | 1987 | 3437108 |
| antifilarial activities of benzazole derivatives. 1. macrofilaricidal effects against litomosoides carinii, dipetalonema viteae, brugia malayi, and b. pahangi in mastomys natalensis. | eighteen 2-tert-butyl-benzazole derivatives were evaluated comparatively as macrofilaricidal agents against l. carinii (l.c.), d. viteae (d.v.), b. malayi (b.m.) and b. pahangi (b.p.). upon repeated treatment (once daily) for five consecutive days the eight benzoxazole derivatives were invariably less potent than the corresponding benzothiazole derivatives. the minimal curative dose (dcm) of the benzoxazoles varied depending on the species and on the chemical structure between 25 and 100 mg/kg p ... | 1988 | 3387822 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 6. the filaricidal activity of organophosphorus compounds. | several organophosphorus compounds have been evaluated for their efficacy against micro- and macrofilariae in experimental investigations on litomosoides carinii infection in the multimammate rat mastomys natalensis. the anthelmintic haloxon proved to be the most effective compound with high activity against microfilariae and a favourable chemotherapeutic range. the organophosphates fenthion, dursban, metrifonate, coumaphos, crufomate and naphthalophos also showed pronounced microfilaricidal act ... | 1975 | 1189030 |
| litomosoides carinii in rodents: immunomodulation in potentiating action of diethylcarbamazine. | the antifilarial activity of combination of diethylcarbamazine (dec) and an immunomodulator, n-palmitoylmuramyl-l-alanyl-d-isoglutamine (np-mdp) was evaluated against litomosoides carinii in cotton rat (sigmodon hispidus) and mastomys natalensis. dec was used at 6 mg/kg in cotton rat whereas it was 75 mg/kg x 5 days in mastomys. the immunomodulator was administered at 62.5 to 500 micrograms/animal x 2 days. combination therapy with optimum dose of immunomodulator resulted in prolonged and signif ... | 1988 | 3075985 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 4. the prophylactic and suppressive activity of suramin. | | 1974 | 4857965 |
| 19s and 7s antibody response of mastomys natalensis in experimental filarial (litomosoides carinii, acanthocheilonema viteae, brugia malayi, b. pahangi) infections. | specific total antibody (ab), 19s and 7s ab levels in the serum of m. natalensis were investigated after infection with l. carinii, a. viteae, b. malayi and b. pahangi for period of about 500 days p.i., using elisa (homologous adult antigen) and indirect immunofluorescence tests (iift: homologous adult and microfilariae antigen). total ab levels in l. carinii infected animals rose moderately during prepatency maximum levels occurred during patency. the response during prepatency was stronger in ... | 1989 | 2781895 |
| altered immune response (humoral and delayed-type hypersensitivity reactions) to sheep red blood cells in the course of experimental filarial infections (litomosoides carinii, brugia malayi, acanthocheilonema viteae) of mastomys natalensis. | litomosoides carinii-, acanthocheilonema viteae- or brugia malayi-infected mastomys natalensis were sensitised against sheep red blood cells (srbc) on various occasions after infection to determine the effect of filarial infections on the immune response to a non-filarial antigen. the phagocytic activity of the reticuloendothelial system (res) was controlled in vivo by the elimination of 51cr-labelled srbc. antibody titres against srbc (agglutinating and lytic antibodies) were similar to those o ... | 1989 | 2726721 |
| 2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone--a new antifilarial agent. | the activity of 2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone (ii, c.d.r.i. comp. 82/437) has been evaluated for its micro- and macro-filaricidal efficacy against litomosoides carinii in rodents. a dose of 3 mg/kg (i.p.) and 50 mg/kg (oral) x 5 days of comp. 82/437 was found to eliminate almost 100% of adult worms and microfilariae of l. carinii in cotton rat. it also killed 100% and 97% of adult worms and microfilariae of dipetalonema viteae and brugia malayi in mastomys natalensis resp ... | 1989 | 2575867 |
| effect of ivermectin on filariae of mastomys natalensis. | the efficacy of ivermectin (iv) was evaluated against four species of filariae, litomosoides carinii, acanthocheilonema viteae, brugia pahangi and brugia malayi in mastomys natalensis. animals with patent infections, induced with l3 larvae, by intravenous (iv) infusion of the respective microfilariae (mf) (5 x 10(4) mf per animal) or by intraperitoneal (ip) route (2 x 10(4) mf per animal) were used in this study. a single dose of iv (100 micrograms.kg-1) given subcutaneously (sc) to mastomys inf ... | 1990 | 2381895 |
| unresponsiveness of lymphocytes in patent filarial infection: modulation by diethylcarbamazine. | the lymphocytes of lymph nodes and spleen of mastomys natalensis infected with litomosoides carinii were unresponsive to specific filarial antigens during patent stage of the infection. the effect of diethylcarbamazine (dec) on these responses has been investigated. dec administered orally at 150 mg/day for 5 days to the animals reduced markedly the circulating levels of microfilariae. at this stage the lymphocyte proliferative responses improved to specific microfilarial antigens. on follow-up ... | 1986 | 3704471 |
| effect of ivermectin in dipetalonema viteae and litomosoides carinii infections of mastomys natalensis. | in d. viteae infected m. natalensis oral or subcutaneous (s.c.) treatment with ivermectin on 5 consecutive days with at least 0.05 mg/kg and single dose treatment with 0.1 mg/kg caused a 100% reduction of microfilaraemia throughout the investigation period of 42 days. using lower doses (lowest dose used 5 x 0.003 mg/kg) animals were free from circulating microfilariae at least until day 7. the drug was active against adult worms. treatment with doses of 5 x 0.2 mg/kg and above resulted in 81-93% ... | 1987 | 3629133 |
| the effect of diethylcarbamazine on microfilariae of litomosoides carinii in vitro and in vivo. | culture-derived litomosoides carinii microfilariae (mff) were used in in vitro and in vivo systems to investigate the effect of diethylcarbamazine (dec) on these mff. in vivo: male rats, mastomys natalensis, all of the same age, were injected intrathoracically (12) or intraperitoneally (36) with 10(3) or 10(4) mff. after 30 min one half of each group of rats was given dec per os. at 30, 60, and 120 min after dec administration, two rats from the treated and two from the untreated group were bled ... | 1986 | 3799010 |
| synthesis and anthelmintic activity of 5(6)-(benzimidazol-2-ylcarbamoyl) and (4-substituted piperazin-1-yl)benzimidazoles. | the synthesis of alkyl 5(6)-(benzimidazol-2-ylcarbamoyl)benzimidazole-2-carbamates (6, 7), and alkyl 5(6)-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (31-40) has been carried out. when the compounds were tested for their anthelmintic activity against ancylostoma ceylanicum in hamsters, hymenolepis nana in rats, litomosoides carinii in cotton rats, and dipetalonema viteae in mastomys natalensis, methyl 5(6)-(4-benzoylpiperazin-1-yl)benzimidazole-2-carbamate (31), methyl 5(6)-[4-(2-fu ... | 1985 | 3906129 |
| immunity to litomosoides carinii in mastomys natalensis. i. effect of immunization with microfilariae and existing primary infections on the parasitaemia after microfilariae injection and challenge infection. | subcutaneous injections of intrauterine stages of litomosoides carinii into mastomys natalensis induced strong immunity to i.v. injected blood microfilariae. immunity, developed after boostering with an i.p. and an i.v. injection of microfilariae, did not totally suppress the parasitaemia of a challenge infection but reduced significantly the microfilaraemia level. no effect was found on number and size of the worms of the challenge infection, the number of microfilariae or the number of leucocy ... | 1985 | 4050030 |
| antifilarial activities of benzazole derivatives. 2. microfilaricidal effects against litomosoides carinii, acanthocheilonema. vitae, brugia malayi and b. pahangi in mastomys natalensis. | the spectrum of antimicrofilarial activities of eighteen 2-tertbutylbenzazole derivatives was evaluated comparatively in mastomys natalensis infected with litomosoides carinii, acanthocheilonema viteae, brugia malayi or b. pahangi. the minimal effective dose (dem) against microfilariae (greater than 95% reduction of microfilariae counts in the peripheral blood) was determined on day 3 (dem-3), on day 7, 14, 21, 28 and 42 (dem-7, dem-14, dem-21, dem-28 and dem-42) after the first treatment. all c ... | 1988 | 3227232 |
| [litomosoides carinii infection of mastomys natalensis: serological studies with the complement fixation and the indirect haemagglutination test in the course of infection (author's transl)]. | | 1974 | 4833626 |
| [chemoprophylactic activity of filaricidal compounds on litomosoides carinii infection of mastomys natalensis (author's transl)]. | | 1977 | 70091 |
| [precipitating antibodies in the serum of mastomys natalensis in the course of litomosoides carinii infection]. | | 1970 | 4993040 |
| [potential filaricides. suramin analogs]. | a series of suramin analogues has been synthesized in which the methyl groups of suramin have been replaced by hydrogen, alkyl, phenyl, and fluoro substituents, or which contain more than two methyl groups. the substances have been screened against dipetalonema viteae in meriones unguiculatus, litomosoides carinii in sigmodon hispidus and l. carinii in mastomys natalensis, respectively. small structural modifications have a marked influence on the antifilarial activity. there are marked differen ... | 1986 | 3778551 |
| [litomosoides carinii infection of mastomys natalensis: alterations of haematological parameters (author's transl)]. | | 1973 | 4770091 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 3. the activity of drugs against adult parasites. | comparative studies of the chemotherapeutic activity of various filaricides were carried out and the results in litomosoides carinii infections of mastomys natalensis were analysed with special reference to macrofilaricidal activity. the administration of suramin in daily subcutaneous doses of 40 mg per kg of body weight for 5 consecutive days showed marked activity against macrofilariae and killed the adult worms within 6 weeks after the beginning of treatment. the microfilarial count of the ci ... | 1971 | 5317447 |
| [the albumin-globulin ratio in the serum of mastomys natalensis (smith, 1834) in the coruse of infection with litomosoides carinii]. | | 1970 | 5436819 |
| some developments in techniques for the study of the rodent filarial parasite litomosoides carinii. i. a preliminary comparison of the host effciency of the multimammate rat, praomys (mastomys) natalensis, with that of the cotton rat, sigmodon hispidus. | | 1968 | 5729256 |
| some developments in techniques for the study of the rodent filarial parasite litomosoides carinii. ii. a quantitative method for the culture of the mite ornithonyssus bacoti and for the routine transmission of litomosoides carinii to praomys (mastomys) natalensis. | | 1968 | 5729257 |
| stage-specific protective immunity to microfilariae of litomosoides carinii in mastomys natalensis. | | 1988 | 3058997 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 2. the activity of drugs against microfilariae. | comparative investigations of the chemotherapeutic activity of various filaricidal compounds and other anthelmintics were made with litomosoides carinii infections in mastomys natalensis, special consideration being given to the microfilaricidal activity of the compounds. diethylcarbamazine, cyclohexanecarboxylic acid-n-methylpiperazide citrate (hoe 28637a), tetrahydropyranecarboxylic acid-n-methylpiperazide citrate (hoe 29691a), (+/-)-tetramisole, (-)-tetramisole (levamisole), and metrifonate p ... | 1971 | 5317446 |
| diethylcarbamazine dependent, complement mediated, adherence and cytotoxicity of cells on microfilariae of litomosoides carinii. | diethylcarbamazine (dec) induced dose dependent adherence of normal spleen cells from mastomys natalensis to microfilariae of l. carinii in the presence of serum from mastomys infected with l. carinii or normal serum. the effect could be also induced, using fresh, normal human serum and human blood leucocytes. the responsible serum factor was heat labile (56 degrees c, 30 min) and was eliminated from the sera by pretreatment with inulin. the activity could be reconstituted by normal serum. cell ... | 1983 | 6136173 |
| different suitability of 3 filarial antigens (litomosoides carinii, dipetalonema viteae, dirofilaria immitis) to act as allergens in the passive cutaneous anaphylaxis test and to serve as antigens in an elisa in the course of experimental filarial infections (l. carinii, d. viteae, brugia malayi, b. pahangi) of mastomys natalensis. | crude extracts of adult worms of 3 different filariae (litomosoides carinii, dipetalonema viteae, dirofilaria immitis) were evaluated for their suitability to serve as allergens in the passive cutaneous anaphylaxis test (pca) and as antigens in an elisa which detected mainly igg antibodies. studies were done in the course of 4 different filarial infections (l. carinii, d. viteae, brugia malayi, b. pahangi) of mastomys natalensis, using sera from different times after infection up to 350 days p.i ... | 1984 | 6143483 |
| shared antigens between litomosoides carinii and its hosts sigmodon hispidus and mastomys natalensis. | using a indirect immunofluorescent technique it has been shown that host or host-like antigens are present on adults and microfilariae of litomosoides carinii from cotton rats and multimammate rats. red blood cell components were seldom detected on any stage but serum antigens were found associated with the cuticle of adults worms. serum components were absent from in utero and in vitro microfilariae but were found on microfilariae from pleural exudate and host blood. these components were lost ... | 1981 | 6179274 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 1. the filaricidal action of 2,6-bis-benzimidazoles. | the antifilarial action of 2-[2-(4-hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl) benzimidazole (hoe 33258) was investigated in mastomys natalensis infected with litomosoides carinii. the subcutaneous administration of hoe 33258 in a single daily dose for 5 consecutive days, or at other intervals, produced, depending on the dosage, a rapid reduction in the number of microfilariae in the circulating blood. the reduction amounted to more than 90% within 7-14 days after the treatment was ... | 1971 | 5317445 |
| sequential changes in antibody response of mastomys natalensis during the course of litomosoides carinii infection. | | 1983 | 6429235 |
| microfilarial periodicity in mastomys natalensis. | the microfilarial level in the peripheral blood of mastomys natalensis infected with the filarial parasites, litomosoides carinii, brugia pahangi, b. malayi and dipetalonema viteae was monitored at two-hour intervals for 24 hours. the microfilariae of b. pahangi and b. malayi exhibited nocturnal and diurnal subperiodicity, respectively; no such periodicity was seen in l. carinii and d. viteae infections. the level of b. pahangi and d. viteae microfilariae in peripheral blood was significantly in ... | 1984 | 6540281 |
| studies of potential filaricides: part 14--activity of 1-iso-butoxycarbonyl-4-methylpiperazine against experimental filariasis. | the synthesis and filaricidal activity of 1-iso-butoxycarbonyl-4-methylpiperazine against litomosoides carinii in sigmodon hispidus and dipetalonema viteae in mastomys natalensis is reported. at an intraperitoneal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariae but had no effect on adult l. carinii. however, it killed all microfilariae and adults of d. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. the compound also possessed chemo ... | 1984 | 6542118 |
| [filariasis of the eye: problems with animal models]. | twelve rodents (mastomys natalensis and meriones persicus) were infected, with l3 larvae of litomosoides carinii and dipetalonema viteae. eighty days after infection the number of microfilariae (l1 larvae) was determined by smears from the peripheral venous blood. it was found that there were 48 and 69 x 10(3) microfilariae per ml blood. the hosts were killed and the eyes (conjunctiva, cornea, uvea, posterior part of the globe, optic nerve) as well as other organs (skin, brain, liver, heart and ... | 1983 | 6645261 |
| comparative efficacy of some benzimidazoles and amoscanate (go.9333) against experimental filarial infections. | the comparative efficacy of mebendazole, fenbendazole, oxibendazole, oxfendazole, albendazole, flubendazole and micronized amoscanate (particle size 5-8 micron) against litomosoides carinii and brugia pahangi infections in mastomys natalensis was studied on administration of the compounds per os (150 mg/kg/day for 5 days) and subcutaneous (100 mg/kg/day for 5 days) routes. it was found that benzimidazoles when given by the oral route had no effect on adults of l. carinii and b. pahangi. with mos ... | 1983 | 6665868 |
| time courses of antibody levels in mastomys natalensis after infections with litomosoides carinii, dipetalonema viteae, brugia malayi or b. pahangi, determined by elisa. | using a litomosoides carinii adult antigen, time courses of antibody levels were followed by an elisa in l. carinii, dipetalonema viteae, brugia malayi and b. pahangi infected mastomys natalensis. using various groups of infected animals, periods up to 400 days after infection were covered. in l. carinii infected mastomys, antibodies were first detected 11 days p.i. and levels increased rapidly until day 40. temporarily reduced levels about the beginning of patency were followed by increasing va ... | 1983 | 6685415 |
| the response to litomosoides carinii to antifilarial agents in cotton rat (sigmodon hispidus) & multimammate rat (mastomys natalensis). | | 1984 | 6394476 |
| [litomosoides carinii infection of mastomys natalensis: relationship between microfilaraemia and adult worm population (author's transl)]. | | 1974 | 4836671 |
| notes on the host-parasite relationship during infection of praomys (mastomys) natalensis with the filarial parasite litomosoides carinii. | | 1974 | 4853378 |
| [infection experiments with the cotton rat filaria litomosoides carinii in mastomys natalensis (smith, 1834)]. | | 1968 | 5746888 |
| synthesis of some novel amodiaquine analogues as potential antimalarial and antifilarial compounds. | ten amodiaquine analogues, which are hybridized molecules of amodiaquine and diethylcarbamazine, were designed and synthesized. six analogues, all bearing a basic tertiary amino function at their side chain, were active against plasmodium berghei in mice and inhibited the mobility of adult worms and microfilariae of breinlia booliati in vitro. they were inactive against litomosoides carinii in mastomys natalensis. the most active antimalarial compound, 7-chloro-4-[alpha-[[n-(4-methyl-1-piperazin ... | 1981 | 7031248 |
| [experiments in vitro with litomosoides carinii (nematoda: filarioidea) ii. influence of different sera on the release of microfilariae and experiments on the readiness for copulation of the worms (author's transl)]. | when fetal calf serum or human serum is added to the culture medium tc 199, adult females of litomosoides carinii release the same amount of microfilariae in vitro as after addition of cotton rat serum. in contrast, in media with serum of meriones unguiculatus or mastomys natalensis only a few microfilariae are released; moreover, addition of mastomys serum immobilizes them. when males and females are kept together, the same amount of microfilariae is released as compared with single females. wo ... | 1982 | 7051596 |
| litomosoides carinii: effect of diethylcarbamazine on microfilaremias of mastomys natalensis harboring old infections, new infections, and transfused microfilariae. | mastomys natalensis, matched according to age and microfilaremia, were divided into experimental and control groups. the former were given diethylcarbamazine (caricide, 500 mg/kg) per os. microfilariae counts were made at 15, 30, 60, and 120 min and at 1, 5, and 12 days. this protocol was performed on rats with: old infections (patent for 7 mo), new infections (patent for 10 days), and no infection but made microfilaremic by injection of blood or culture-derived microfilariae. in all treated gro ... | 1982 | 7175613 |
| filarial infections of mastomys natalensis and their relevance for experimental chemotherapy. | experimental filarial infections of mastomys natalensis, strain gra giessen, with litomosoides carinii, dipetalonema viteae, brugia malayi (subperiodic), and brugia pahangi were compared. mean prepatent periods of 52, 57, 107, and 73 days p.i. were observed after subcutaneous inoculation of 40, 50, 85, and 70 infective larvae of l. carinii, d. viteae, b. malayi, and b. pahangi, respectively, in the neck region. all of the l. carinii, d. viteae, and b. pahangi infected mastomys showed a regularly ... | 1981 | 6118036 |
| effect on host metabolism of litomosoides carinii infection in mastomys natalensis. | | 1981 | 7348724 |
| occurrence of microfilariae in various hollow organs and in the peritoneal cavity after treatment of litomosoides carinii infected mastomys natalensis with diethylcarbamazine and haloxon. | treatment of litomosoides carinii infected mastomys natalensis with diethylcarbamazine (dec: 500 mg/kg p.o.) was followed by increased occurrence of microfilariae in the bronchi of the host after 40 min and lasting at least until 6 h after treatment. after 4 h, increased levels of larvae were observed in the gut. only a few microfilariae occurred in the bladder and sputum. accumulations of microfilariae were found furthermore in the lnn. hepaticae whereas no changes were observed in the inguinal ... | 1983 | 6880345 |