nectin-4 interactions govern measles virus virulence in a new model of pathogenesis, the squirrel monkey (saimiri sciureus).in addition to humans, only certain nonhuman primates are naturally susceptible to measles virus (mev) infection. disease severity is species dependent, ranging from mild to moderate for macaques to severe and even lethal for certain new world monkey species. to investigate if squirrel monkeys (saimiri sciureus), which are reported to develop a course of disease similar to humans, may be better suited than macaques for the identification of virulence determinants or the evaluation of therapeutic ...201728331086
host and viral traits predict zoonotic spillover from mammals.the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...201728636590
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