| experimental infection and the state of viral latency of adult tupaia with herpes simplex virus type 1 and 2 and infection of juvenile tupaia with temperature-sensitive mutants of hsv type 2. | the susceptibility of adult tupaia belangeri to infection with herpes simplex virus (hvs) was investigated. adult animals were inoculated intraperitoneally with hsv type 1 or 2. with the exception of hsv-2, strain hg-52, 10(5)--10(6) pfu of all hsv strains caused lethal infection irrespective of the age of the animals. infections hsv was recovered from the spinal cord of those animals which had survived infection with a low dose of virus. the dna of the recovered viruses was compared to the dna ... | 1980 | 6251787 |
| [sero-epidemiology of six viruses natural infection in tupaia belangeri chinensis]. | tupaia (tupaia belangeris chinensis, tree shrew) as a new experiment animal in medicine are non-rodent, small animals and close to primates in evolution. experimental animals infected with viruses will affect the animal's health, interference experiment, and even endanger the operator's safety. therefore, the viral infection in experimental animals has long been considered an important part of quality control. lack of clearer viral natural infection information on the t. belangeris limits its us ... | 2011 | 21341379 |
| herpes simplex virus 1 infection of tree shrews differs from that of mice in the severity of acute infection and viral transcription in the peripheral nervous system. | studies of herpes simplex virus (hsv) infections of humans are limited by the use of rodent models such as mice, rabbits, and guinea pigs. tree shrews (tupaia belangeri chinensis) are small mammals indigenous to southwest asia. at behavioral, anatomical, genomic, and evolutionary levels, tree shrews are much closer to primates than rodents are, and tree shrews are susceptible to hsv infection. thus, we have studied herpes simplex virus 1 (hsv-1) infection in the tree shrew trigeminal ganglion (t ... | 2015 | 26512084 |