| heterologous expression and functional characterization of avian mu-class glutathione s-transferases. | hepatic glutathione s-transferases (gsts: ec2.5.1.1.8) catalyze the detoxification of reactive electrophilic compounds, many of which are toxic and carcinogenic intermediates, via conjugation with the endogenous tripeptide glutathione (gsh). glutathione s-transferase (gst)-mediated detoxification is a critical determinant of species susceptibility to the toxic and carcinogenic mycotoxin aflatoxin b1 (afb1), which in resistant animals efficiently detoxifies the toxic intermediate produced by hepa ... | 2013 | 23712008 |