| evaluation of plasma (1-->3) beta-d-glucan concentrations in birds naturally and experimentally infected with aspergillus fumigatus. | avian aspergillosis, most often caused by aspergillus fumigatus, is a common and devastating disease affecting a range of bird species. early diagnosis is difficult and often unreliable. the current study evaluated the utility of measuring (1-->3)-beta-d-glucan (bg) concentrations in avian plasma samples to aid in the diagnosis of aspergillosis. we evaluated a commercially available bg assay (fungitell, beacon diagnostics) using 178 plasma samples from naturally infected, experimentally infected ... | 2012 | 22545545 |
| efficacy of voriconazole in japanese quail (coturnix japonica) experimentally infected with aspergillus fumigatus. | aspergillus fumigatus causes disease in birds. our objectives were to determine pharmacokinetic parameters and evaluate efficacy of voriconazole (vcz) in a novel experimental quail model. after a single oral vcz dose of 20 or 40 mg/kg, plasma concentrations peaked 2 h postdose (5.8 and 6.9 microg/ml) and remained above 0.5 microg/ml for 4 and 12 h postdose, respectively. for the efficacy study, ten-day-old japanese quail (n = 60) were infected intratracheally with a. fumigatus conidia. daily ora ... | 2010 | 19548171 |
| experimental aspergillus fumigatus infection in quails and results of treatment with itraconazole. | this study was performed to investigate (i). the clinical, histopathological and biochemical changes in quails (coturnix coturnix japonica) with experimentally induced aspergillosis; and (ii). the efficiency of itraconazole treatment on these infected birds. a total of 18021-day-old male quails was randomly divided into three groups (control, infected untreated and infected treated), each containing 60. the experimental infection was set by intratracheal inoculation of 0.2 ml inoculum of aspergi ... | 2004 | 14995975 |
| sequential pathological studies in japanese quails infected experimentally with aspergillus fumigatus. | intratracheal inoculation of young quail chicks with aspergillus fumigatus spores resulted in the development of characteristic gross and microscopic lesions. the lesions were restricted to respiratory tract and there was no dissemination of infection to other tissues of the body. gross changes in lungs and air sacs were observed within 24 hours and continued up to 20 days while in trachea these were noticed from the 3rd to the 9th day post-infection. the lesions, in general, included congestion ... | 1988 | 3057379 |
| experimental aspergillosis in japanese quails (coturnix coturnix japonica). clinical signs and haematological changes. | intratracheal inoculation of 2-week-old quail chicks with aspergillus fumigatus resulted in the development of clinical signs within 24 h of infection. these were characterized by anorexia, depression, accelerated respiration and gasping followed by death. the acute course of the disease lasted for 7-10 days followed by recovery in the surviving chicks. the overall mortality during a 6-week observation period was 20%. although the mean body weight of a. fumigatus infected quail chicks continued ... | 1988 | 3050527 |
| a model for treating avian aspergillosis: serum and lung tissue kinetics for japanese quail (coturnix japonica) following single and multiple aerosol exposures of a nanoparticulate itraconazole suspension. | aspergillosis is frequently reported in parrots, falcons and other birds held in captivity. inhalation is the main route of infection for aspergillus fumigatus, resulting in both acute and chronic disease conditions. itraconazole (itra) is an antifungal commonly used in birds, but administration requires repeated oral dosing and the safety margin is narrow. we describe lung tissue and serum pharmacokinetics of a nanoparticulate itra suspension administered to japanese quail by aerosol exposure. ... | 2013 | 23815436 |
| inflammatory marker profiles in an avian experimental model of aspergillosis. | aspergillosis is a common infection in avian species, but can be a challenge to diagnose. inflammatory markers have been successfully used in mammals for diagnostic and monitoring purposes of various diseases. the aim of this study was to identify inflammatory markers that could aid in the diagnosis of aspergillosis in an avian species. five-week-old japanese quail were infected experimentally with aspergillus fumigatus, and inflammatory markers were measured in plasma. in addition, lung tissues ... | 2013 | 23651177 |
| activity and safety of inhaled itraconazole nanosuspension in a model pulmonary aspergillus fumigatus infection in inoculated young quails. | pulmonary aspergillosis is frequently reported in parrots, falcons, and other birds held in captivity. inhalation is the main route of infection for aspergillus fumigatus, resulting in both acute and chronic disease conditions. itraconazole (itra) is an antifungal commonly used in birds, but its administration requires repeated oral dosing, and the safety margin is narrow. to investigate the efficacy of inhaled itra, six groups of ten young quails (coturnix japonica) were inoculated intratrachea ... | 2015 | 25790942 |