| properties of aleutian disease virus assayed with feline kidney cells. | properties of aleutian disease virus (adv) were studied using feline kidney cells, line crfk, to assay virus by the induction of nuclear antigen. adv nuclear antigen was detected by immunofluorescent staining. titers of virus obtained from mink spleens at 10-8 days after infection were usually between 10(3) and 10(5) infectious units per gram of spleen. adv was purified by fluorocarbon extraction, differential centrifugation, biogel a-15 chromatography and cscl equilibrium centrifugation. the mo ... | 1977 | 202229 |
| restricted viral antibody specificity in many ferrets infected with the ferret aleutian disease parvovirus. brief report. | the majority of ferrets infected with a ferret strain of aleutian disease virus (adv) produce antibody only to a detergent-sensitive common determinant on the two closely related virion proteins. ferrets with high antibody titers and mink infected with this virus also produce antibody to one or more virion immunogenic determinants unaffected by detergent. | 1987 | 2434063 |
| experimental transmission of aleutian disease virus (adv) to different animal species. | two animals from each of 8 different species (mink, finn raccoon, cat, dog, ferret, blue fox, mouse and rabbit) were inoculated with the highly virulent utah i strain of adv. only the mink developed hypergammaglobulinemia. all animals produced antibodies to adv antigens, but with different titres. mink sera had much higher antibody titres than the other animal sera. antibodies to the adv-coded, non-structural polypeptide (p71) were found in mink, finn raccoons and dogs only. presence of this kin ... | 1985 | 2994362 |
| aleutian disease virus in b and t lymphocytes from blood and spleen and in bone marrow cells from naturally infected mink. | in the nuclei of 4% of peripheral blood or spleen mononuclear cells (mnc), aleutian disease virus(adv)-specific antigens were found by a direct immunofluorescence test. the mnc were further fractionated by nylon wool, affinity chromatography using staphylococcus aureus protein, or percoll gradient techniques. adv and specific antigens were detected in mnc fractions enriched in either the b or t lymphocytes. in the bone marrow, up to 40% antigen-positive cells were demonstrated over a period of 1 ... | 1984 | 6096293 |
| aleutian disease in ferrets. | when 32 antibody-free ferrets were inoculated with the highly mink-virulent utah-1 strain of aleutian disease virus (adv), most developed adv antibody starting 15 days after infection, but the antibody titers were much lower than those seen in mink. relatively small amounts of adv were demonstrated in crfk cell culture, using ferret spleen and lymph node homogenates only 4 to 10 days after experimental infection, but low-level viral persistence for 180 days was shown by mink inoculation. the fer ... | 1982 | 6176546 |
| clusters of lymphoma in ferrets. | cluster outbreaks of lymphoma and leukemia have been associated with viral infections in many species including humans, cattle, and cats. this study describes epidemiological, clinical, and pathological features of cluster outbreaks of lymphoma in multiferret households and examines and compares the aleutian disease virus (adv) and feline leukemia virus (felv) status of cases, ferrets at risk, and controls. three ferret groups with 21 cases of histologically diagnosed lymphoma (12.6% cumulative ... | 1996 | 8630683 |
| identification of a dna segment in ferret aleutian disease virus similar to a hypervariable capsid region of mink aleutian disease parvovirus. | a 401bp dna fragment of ferret aleutian disease virus (adv) was amplified using pcr primers spanning a hypervariable region of mink adv capsid sequence. the amplified fragment was 88-89% homologous to the same region of previously known sequence of three different strains of mink adv, however, as low as 54% homology was observed when compared with a 39bp segment known as hypervariable region. within the predicted 13 amino acid hypervariable region, the ferret adv sequence differed at 6 positions ... | 1996 | 8774691 |
| a cluster of cases of juvenile mediastinal lymphoma in a ferret colony. | three cases of juvenile mediastinal lymphoma developed in a laboratory colony of ferrets. two ferrets became acutely moribund, and one was found dead with no preceding signs of illness. splenomegaly, hepatomegaly, and a large thoracic mass were the primary features in each case. all three ferrets had multiorgan metastasis of the tumor. two ferrets were tested for feline leukemia virus and aleutian disease virus with negative results. | 1996 | 8799931 |
| nucleotide sequence and polymerase chain reaction/restriction fragment length polymorphism analyses of aleutian disease virus in ferrets in japan. | two ferrets with spontaneous aleutian disease (ad) were found in japan. the diagnosis was verified by polymerase chain reaction (pcr) amplification of part of the capsid gene specific to ad virus (adv). the nucleotide sequences (365 bp in length) of the amplified fragments from the 2 ferrets differed by a single nucleotide, producing an amino acid alteration. compared with other types of adv, these isolates had 96% sequence similarity to a published ferret adv (fadv) in contrast to <91% homology ... | 2001 | 11478607 |
| persistent viral shedding during asymptomatic aleutian mink disease parvoviral infection in a ferret. | a 2-year-old domestic ferret that appeared clinically healthy was repeatedly seropositive for aleutian mink disease parvovirus (adv) over a 2-year observation period. antibody titers, determined by counter-immunoelectrophoresis, ranged from 1024 to 4096. viral dna also was identified in serum, urine, feces, and blood cell fractions by polymerase chain reaction analysis. ultimately, dna in situ hybridization revealed adv dna in histologic sections of various tissues and organs. these data indicat ... | 2005 | 16475522 |
| amdoparvoviruses in small mammals: expanding our understanding of parvovirus diversity, distribution, and pathology. | many new viruses have been discovered recently, thanks in part to the advent of next-generation sequencing technologies. among the parvoviridae, three novel members of the genus amdoparvovirus have been described in the last 4 years, expanding this genus that had contained a single species since its discovery, aleutian mink disease virus. the increasing number of molecular and epidemiological studies on these viruses around the world also highlights the growing interest in this genus. some aspec ... | 2015 | 26528267 |
| driving forces behind the evolution of the aleutian mink disease parvovirus in the context of intensive farming. | aleutian mink disease virus (amdv) causes plasmacytosis, an immune complex-associated syndrome that affects wild and farmed mink. the virus can also infect other small mammals (e.g., ferrets, skunks, ermines, and raccoons), but the disease in these hosts has been studied less. in 2007, a mink plasmacytosis outbreak began on the island of newfoundland, and the virus has been endemic in farms since then. in this study, we evaluated the molecular epidemiology of amdv in farmed and wild animals of n ... | 2016 | 27774297 |
| corrigendum: amdoparvoviruses in small mammals: expanding our understanding of parvovirus diversity, distribution, and pathology. | [this corrects the article on p. 1119 in vol. 6, pmid: 26528267.]. | 2016 | 26973636 |
| aleutian disease: an emerging disease in free-ranging striped skunks (mephitis mephitis) from california. | aleutian disease virus (adv, amdovirus, parvoviridae) primarily infects farmed mustelids (mink and ferrets) but also other fur-bearing animals and humans. three aleutian disease (ad) cases have been described in captive striped skunks; however, little is known about the relevance of ad in free-ranging carnivores. this work describes the pathological findings and temporospatial distribution in 7 cases of ad in free-ranging striped skunks. all cases showed neurologic disease and were found in a 46 ... | 2015 | 25445322 |