| characterization of primate trypanosome lytic factors. | humans are one of the few species that resist infection by trypanosoma brucei brucei because the parasites are killed by lytic factors found in human serum. trypanosome lytic factors (tlfs) are protein/lipid complexes that contain apolipoprotein a-i (apoa-i), and are therefore a class of high density lipoproteins (hdls). haptoglobin-related protein (hpr) is a unique protein component of tlfs, and its expression has only been demonstrated in humans. trypanolytic activity has only been found in th ... | 2004 | 15500911 |
| wild chimpanzees are infected by trypanosoma brucei. | although wild chimpanzees and other african great apes live in regions endemic for african sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. in present work, we established a diagnostic its1-based pcr assay that allows detection of the dna of all four trypanosoma brucei subspecies (trypanosoma brucei brucei, trypanosoma brucei rhodesiense, trypanosoma brucei gambiense, and trypanosoma brucei evansi) in f ... | 2015 | 26110113 |
| a survey for a trypanocidal factor in primate sera. | the sera of 21 different species of primates were surveyed for the presence of a trypanocidal factor to a monomorphic human serum-sensitive clone of trypanosoma brucei gambiense (t.b.g.); human, gorilla, baboon (2 species), and the mandrill were found to contain this factor. the factor in all the sera is in the high density lipoprotein (hdl) fraction, and has similar modes of biological action. it has been shown that the human and gorilla trypanocidal factor share cross-reactive antigenic epitop ... | 1990 | 2120433 |