| l-658,310, a new injectable cephalosporin. iii. experimental chemotherapeutics and pharmacokinetics in laboratory animals. | the therapeutic activity of l-658,310 was demonstrated in experimental bacteremias in normal, diabetic and neutropenic mice. especially potent activity was shown against the usually difficult to control pathogens, enterobacter cloacae and pseudomonas aeruginosa, that were resistant to ceftazidime and/or gentamicin. pharmacokinetic studies in mice showed a linear dose response in serum after the 20 and 50 mg/kg subcutaneous dose and urinary recoveries of administered dose of about 60% in 6 hours. ... | 1989 | 2656617 |
| comparison of gentamicin, carbenicillin and gentamicin, and carbenicillin in pseudomonas sepsis in monkeys. | intravenous inoculation of 6.0 x 10(10)pseudomonas aeruginosa organisms into rhesus monkeys 4 days after intratracheal inoculation of 2.5 mg of vincristine sulfate resulted in fatal sepsis in all of three untreated control monkeys. after intramuscular administration of either 2.5 mg of gentamicin or 50 mg of carbenicillin per kg per day, three of four monkeys in each group survived. when both antibiotics were given at the same dose but in separate sites, six of eight monkeys survived. antibacter ... | 1973 | 4208283 |
| blocking of pseudomonas aeruginosa and chromobacterium violaceum lectins by diverse mammalian milks. | pseudomonas aeruginosa and chromobacterium violaceum morbid and mortal infections are initiated by bacterial adherence to host-cell receptors via their adhesins, including lectins (which also contribute to bacterial biofilm formation). pseudomonas aeruginosa produces a galactophilic lectin, pa-il (leca), and a fucophilic (lewis-specific) lectin, pa-iil (lecb), and c. violaceum produces a fucophilic (h-specific) lectin, cv-iil. the antibiotic resistance of these bacteria prompted the search for g ... | 2010 | 20105519 |
| comparison of colistin-carbenicillin, colistin, and carbenicillin in pseudomonas sepsis in monkeys. | intravenous inoculation of 6.2 x 10(10) to 6.7 x 10(10)pseudomonas aeruginosa organisms into rhesus monkeys 5 days after intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate resulted in fatal sepsis in 8 of 10 untreated monkeys. when similarly infected monkeys were treated intramuscularly with 2.5 mg of colistin or 50 mg of carbenicillin per kg per day, all three monkeys in each treatment group survived; one of three monkeys receiving both antibiotics at the above doses died. six of ... | 1973 | 4208276 |
| comparison of tobramycin, gentamicin, colistin, and carbenicillin in pseudomonas sepsis in monkeys. | intravenous inoculation of 3.4 x 10(10) to 7.4 x 10(10)pseudomonas aeruginosa organisms into rhesus monkeys 4 days after intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate resulted in fatal sepsis in eight of nine monkeys. after intramuscular administration, in two equal doses, of 5 mg of tobramycin, gentamicin, and colistin per kg per day beginning 16 hr after challenge, 4 of 11, 4 of 11, and 3 of 10 monkeys died, respectively. administration of daily doses of 100 ... | 1972 | 4208275 |
| chronic pseudomonas aeruginosa endobronchitis in rhesus monkeys: i. effects of pentoxifylline on neutrophil influx. | host defense abnormalities in cystic fibrosis (cf) against pseudomonas aeruginosa (pa) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. we have developed a rhesus monkey model of chronic pa endobronchitis by intrabronchial instillation of pa-embedded agar beads, utilizing flexible fiberoptic bronchoscopy. treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. the results suggest a method b ... | 1992 | 1307753 |
| binding of mouse mannan-binding lectins to different bacterial pathogens of mice. | humans have one mannan-binding lectin (mbl) in circulation but rodents, pigs, rabbits and rhesus monkeys have two, mbl-a and mbl-c. plasma forms of these proteins have similar mannan-binding activity in vitro, but might differ in their ability to bind other microbial targets. in these studies, we compared carbohydrate-dependent binding of mouse plasma mbl-a and mbl-c to mannan-sepharose beads and to intact bacteria isolated as pathogens from mice. after incubation of mouse plasma with intact bac ... | 2007 | 17493687 |
| anti-hiv-1 immunotoxin 3b3(fv)-pe38: enhanced potency against clinical isolates in human pbmcs and macrophages, and negligible hepatotoxicity in macaques. | highly active antiretroviral therapy (haart) against human immunodeficiency virus type 1 (hiv-1) infection dramatically suppresses viral load, leading to marked reductions in hiv-1 associated morbidity and mortality. however, infected cell reservoirs and low-level replication persist in the face of suppressive haart, leading invariably to viral rebound upon cessation of treatment. toxins engineered to target the env glycoprotein on the surface of productively infected cells represent a complemen ... | 2006 | 16923920 |
| transgenic cystic fibrosis mice exhibit reduced early clearance of pseudomonas aeruginosa from the respiratory tract. | the cystic fibrosis (cf) transmembrane conductance regulator (cftr) has been proposed to be an epithelial cell receptor for pseudomonas aeruginosa involved in bacterial internalization and clearance from the lung. we evaluated the role of cftr in clearing p. aeruginosa from the respiratory tract using transgenic cf mice that carried either the deltaf508 cftr allele or an allele with a cftr stop codon (s489x). intranasal application achieved p. aeruginosa lung infection in inbred c57bl/6 deltaf50 ... | 2001 | 11390493 |
| pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. | liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by mycobacterium avium. amikacin in small, low-clearance liposomes (mikasome) also has curative and prophylactic efficacies against pseudomonas aeruginosa and klebsiella pneumoniae. to develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary ... | 1999 | 10049258 |
| chronic pseudomonas aeruginosa endobronchitis in rhesus monkeys: ii. a histopathologic analysis. | we have recently established a rhesus monkey model of chronic pseudomonas aeruginosa (pa) endobronchitis by bronchoscopic instillation of pa-embedded agar beads. all experimental animals developed chronic neutrophilic endobronchitis similar to chronic pa endobronchitis in cystic fibrosis (cf). histopathologic studies further confirmed similarities to chronic pa endobronchitis in cf, including marked peribronchial inflammation, epithelial damage, presence of degraded cilia and ciliary abnormaliti ... | 1993 | 8230177 |
| effect of vincristine sulfate on pseudomonas infections in monkeys. | in rhesus monkeys, intravenous challenge with 0.6 x 10(10) to 2.2 x 10(10)pseudomonas aeruginosa organisms caused acute illness of 4 to 5 days' duration with spontaneous recovery in 13 of 15 monkeys; blood cultures became negative 3 to 17 days after challenge. leukocytosis was observed in all monkeys. intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate was followed by leukopenia in 4 to 5 days. intravenous inoculation of 4.2 x 10(10) to 7.8 x 10(10) pyocin type 6 pse ... | 1972 | 4631913 |