| enrofloxacin treatment of long-tailed macaques with acute bacillary dysentery due to multiresistant shigella flexneri iv. | thirty-four cases of acute bacillary dysentery occurred within 90 days among macaques housed at the california regional primate research center. cases were identified by depression, diarrhea with blood and leukocytic exudate, and/or leukocytosis with a left shift. antimicrobial susceptibility testing of enteric isolates and plasmid profile analyses established an etiologic diagnosis of multiple antibiotic resistant shigella flexneri iv infection. when standard therapies were invalidated by high ... | 1992 | 1320152 |
| auxotrophic live oral shigella flexneri vaccine protects monkeys against challenge with s. flexneri of different serotypes. | the aromatic-dependent live shigella flexneri y strain sfl114, attenuated by a tn10-inactivated arod gene, was given as an oral vaccine to 14 macaca fascicularis monkeys. a significant clinical attenuation of sfl114 was seen (p = 0.0058) as all vaccinated monkeys tolerated 2 x 10(10)-1 x 10(11) bacteria of sfl114, whereas four out of seven monkeys orally given 1 x 10(11) of the virulent parent strain sfl1 developed shigellosis. the average excretion time for sfl114 and sfl1 were 2 and 18 days, r ... | 1992 | 1557932 |
| live oral auxotrophic shigella flexneri sfl124 vaccine with a deleted arod gene: characterization and monkey protection studies. | shigella flexneri sfl124, with a deletion encompassing all, or nearly all, of the coding sequence of gene arod was obtained after selection on a fusaric acid medium supplemented with 2,3-dihydroxybenzoic acid for tetracycline-sensitive mutants of s. flexneri sfl114 which is an arod::tn10 transductant. two of 20 tetracycline-sensitive mutants tested in colony hybridization with a 32p-labelled dna probe of approximately 1400 base pairs (comprising all except the 75 n-terminal base pairs of the cod ... | 1992 | 1598787 |
| shigella flexneri infection: a histopathologic study of colonic biopsies in monkeys infected with virulent and attenuated bacterial strains. | macaca fascicularis monkeys were orally infected with live virulent shigella flexneri wild-type strains of either serotype y (s. flexneri sfl1), 2a (s. flexneri m4243) or 1b (s. flexneri sfl27). clinical signs of shigellosis varied from mild watery diarrhea (sfl1) to dysentery (m4243, sfl27), with a fatal outcome in two monkeys (sfl27). colonoscopy showed slight pathologic changes in monkeys infected with sfl1, and pronounced changes in monkeys infected with sfl27. in colonic biopsies the most s ... | 1991 | 1892634 |
| shigellosis in cynomolgus monkeys (macaca irus). iv. bacteriological and histopathological observations on the earlier stage of experimental infection with shigella flexneri 2 a. | | 1966 | 4958740 |
| experimental infection with small doses of virulent shigella flexneri 2a in cynomolgus monkeys (macaca irus). clinical and bacteriological observations. | | 1967 | 4964232 |
| shigellosis in cynomolgus monkeys (macaca irus). v. resistance acquired by the repetition of experimental oral infection with shigella flexneri 2a and fluctuation of serum agglutinin titer. | | 1967 | 4966140 |
| oral challenge with shigella flexneri 2a in cynomolgus monkeys having extremely high titer of serum agglutinin. | | 1968 | 4974278 |
| shigellosis in cynomolgus monkeys (macaca irua). vi. the inoculation with various doses of shigella flexneri 2a into cecal lumen. | | 1968 | 4974847 |
| shigellosis in cynomolgus monkeys (macaca irus). vii. experimental production of dysentery with a relatively small dose of shigella flexneri 2a in ascorbic acid deficient monkeys. | | 1969 | 4981384 |
| dysentery produced by oral administration of the colonic contents of cynomolgus monkeys infected with shigella flexneri 2a. | | 1970 | 4992614 |
| bacillary dysentery in cynomolgus monkeys following the administration with shigella flexneri 2a by the anal route. | | 1971 | 5003951 |
| yersinia pseudotuberculosis infection in a group of macaca fascicularis. | diarrheal disease associated with abortions and stillbirths occurred in a group of 42 macaca fascicularis. the group was composed of wild-caught adults and their colony-born offspring housed in a half-acre cage. thirteen adult females and 1 infant male were affected. all 14 monkeys had diarrhea and all 9 pregnant females either aborted or had a stillbirth. yersinia pseudotuberculosis was isolated from 7 animals. in addition, y enterocolitica was isolated from 1 monkey and shigella flexneri type ... | 1980 | 7005202 |
| arod deletion attenuates shigella flexneri strain 2457t and makes it a safe and efficacious oral vaccine in monkeys. | the aromatic-dependent live shigella flexneri 2a vaccine strain sfl1070, with a deleted arod gene, had a much reduced intracellular growth in hela cells compared with its parent strain s. flexneri 2457t. s. flexneri sfl1070 gave no adverse effects in eight macaca fascicularis monkeys orally vaccinated with four doses of 1 x 10(11) live bacteria within a 5-week period, whereas s. flexneri 2457t caused dysentery in all eight non-vaccinated monkeys. thus the aromatic dependency rendered s. flexneri ... | 1993 | 8356844 |
| shigellosis due to occupational contact with non-human primates. | a small cluster of dysenteric illness, due to shigella flexneri, was identified among technical assistants of a primate research unit. all of the affected individuals had been in regular contact with a colony of cynomolgus macaque monkeys, one of which was known to have suffered from acute haemorrhagic colitis in the preceding few weeks. four monkeys were found to be excreting s. flexneri bacilli of identical antigen type (1b) to that isolated from the human cases. investigation of working pract ... | 1993 | 8472767 |
| construction and evaluation of a virg thya double mutant of shigella flexneri 2a as a candidate live-attenuated oral vaccine. | a virg thya double mutant of shigella flexneri 2a was constructed as a candidate live-attenuated oral vaccine. in the keratoconjunctivitis model it did not provoke any adverse reaction by itself on guinea pigs' eyes and completely protected them from provoking keratoconjunctivitis. when (2.7-4.8) x 10(10) of the vaccine was inoculated intragastrically after 1 day fasting in cynomolgus monkeys three times at weekly intervals, a watery stool was observed at 40% as a side-effect. upon intragastric ... | 1995 | 8578822 |
| lack of reactivation of shigellosis in naturally infected enrofloxacin-treated cynomolgus monkeys after exogenous immunosuppression. | four cynomolgus macaques housed at our facility became acutely ill with dysenteric symptoms. enteric isolates established an etiologic diagnosis of shigella flexneri. enrofloxacin antimicrobial therapy cleared the infection with no perceptible bacterial shedding or clinical signs of disease. high-dose methyl-prednisolone therapy was administered to the four monkeys for 5 weeks. the animals were monitored for signs of shigellosis and bacterial shedding weekly throughout the study, for a total of ... | 1997 | 9433696 |
| shigellosis in cynomolgus monkeys (macaca irus). ii. experimental infection with shigella flexneri 2a with special references to clinical and bacteriological findings. | | 1964 | 14279864 |