| pandemic swine-origin h1n1 influenza virus replicates to higher levels and induces more fever and acute inflammatory cytokines in cynomolgus versus rhesus monkeys and can replicate in common marmosets. | the close immunological and physiological resemblance with humans makes non-human primates a valuable model for studying influenza virus pathogenesis and immunity and vaccine efficacy against infection. although both cynomolgus and rhesus macaques are frequently used in influenza virus research, a direct comparison of susceptibility to infection and disease has not yet been performed. in the current study a head-to-head comparison was made between these species, by using a recently described swi ... | 2015 | 25946071 |
| non-human primate orthologues of tmprss2 cleave and activate the influenza virus hemagglutinin. | the cellular serine protease tmprss2, a member of the type ii transmembrane serine protease (ttsp) family, cleaves and activates the hemagglutinin of influenza a viruses (fluav) in cell culture and is essential for spread of diverse fluav in mice. non-human primates (nhp), in particular rhesus and cynomolgus macaques, serve as animal models for influenza and experimental fluav infection of common marmosets has recently also been reported. however, it is currently unknown whether the nhp ortholog ... | 2017 | 28493964 |