| plasmodium falciparum: passive immunization of aotus lemurinus griseimembra with immune serum. | owl monkeys (aotus lemurinus griseimembra) were immunized against plasmodium falciparum by infection and drug cure. after challenge, 3 of 4 monkeys developed extended prepatent periods and low grade parasitemias followed by self cure. the fourth monkey did not develop a patent infection. immune monkey serum passively transferred at the time of challenge conferred immunity to 20 naive monkeys. immunity was characterized by extended prepatent periods in 19 monkeys, low levels of parasitemia (< or ... | 1995 | 7895839 |
| a recombinant baculovirus 42-kilodalton c-terminal fragment of plasmodium falciparum merozoite surface protein 1 protects aotus monkeys against malaria. | the immunogenicity and protective efficacy of baculovirus recombinant polypeptide based on the plasmodium falciparum merozoite surface protein 1 (msp-1) has been evaluated in aotus lemurinus griseimembra monkeys. the msp-1-based polypeptide, bvp42, corresponds to the 42-kda c-terminal processing fragment of the precursor molecule. immunization of aotus monkeys with bvp42 in complete freund's adjuvant resulted in high antibody titers against the immunogen as well as parasite msp-1. fine specifici ... | 1996 | 8557348 |
| the santa lucia strain of plasmodium falciparum as a model for vaccine studies. i. development in aotus lemurinus griseimembra monkeys. | the santa lucia strain of plasmodium falciparum and the aotus lemurinus griseimembra monkey are proposed as models for the testing of sporozoite vaccines and transmission-blocking vaccines. approximately 85% of splenectomized monkeys were infected when fed upon by 10 or more heavily infected anopheles freeborni mosquitoes. sporozoite-induced infections in monkeys with or without previous infection with p. vivax readily infected mosquitoes, thus making them candidates for testing transmission-blo ... | 1996 | 8615450 |
| the santa lucia strain of plasmodium falciparum as a model for vaccine studies. ii. development of aotus vociferans as a model for testing transmission-blocking vaccines. | the santa lucia strain of plasmodium falciparum and the aotus vociferans monkey were studied as models for the testing of transmission-blocking vaccines. virulence developed early in the passage history. despite the use of only small quantities of chlorguanide and/or quinine to control infection coupled with the use of small inocula and delays in splenectomy, mosquito infection was markedly reduced from that seen during primary passage to this species of aotus. it appears that the model may be m ... | 1996 | 8615451 |
| reproducible infection of intact aotus lemurinus griseimembra monkeys by plasmodium falciparum sporozoite inoculation. | aotus lemurinus griseimembra is considered one of the best nonhuman primate species for malarial studies because of its susceptibility to infection by plasmodium falciparum asexual blood stages. however, reproducible transmission of infective p. falciparum sporozoites by mosquito inoculation has been difficult to achieve even in splenectomized monkeys. characterization of an aotus-p. falciparum cyclical transmission model has become a top priority as a result of the significant progress toward t ... | 2002 | 12197121 |
| aotus monkeys: their great value for anti-malaria vaccines and drug testing. | non-human primates represent a valuable resource for testing potential vaccines candidates and drugs for human use. malaria remains one of the greatest burdens for the humanity represented by approximately 500 million new clinical cases per year worldwide and at least two million deaths caused annually. additional control measures such as vaccines and new anti-malarial compounds are therefore urgently needed. safety and protective efficacy studies in animal models are critical steps for vaccines ... | 2002 | 12435447 |
| immunogenicity and protective efficacy of plasmodium falciparum liver-stage ag-3 in aotus lemurinus griseimembra monkeys. | three recombinant proteins spanning the plasmodium falciparum liver-stage ag-3 (lsa-3) were used to immunize aotus monkeys. the proteins were delivered subcutaneously without adjuvant, adsorbed onto polystyrene 0.5 microm particles at a concentration of 2 microg per immunization. control animals received glutathione-s-transferase formulated similarly. animals were challenged as late as 5 months after the last immunization, by intravenous inoculation of 100,000 p. falciparum sporozoites of a stra ... | 2003 | 12731057 |
| adaptation of a strain of plasmodium falciparum from ghana to aotus lemurinus griseimembra, a. nancymai, and a. vociferans monkeys. | a strain of plasmodium falciparum from ghana was adapted to aotus lemurinus griseimembra, a. nancymai, and a. vociferans monkeys. gametocytes in splenectomized a. nancymai were infective to anopheles freeborni mosquitoes. sporozoite transmission was accomplished in two splenectomized a. nancymai with prepatent periods of 22 and 25 days. the ghana iii/cdc strain of p. falciparum is susceptible to treatment with chloroquine and mefloquine. | 2003 | 14740874 |
| observations on the vietnam palo alto strain of plasmodium vivax in two species of aotus monkeys. | thirty-three splenectomized aotus lemurinus griseimembra monkeys with no previous experience with malaria were infected with the vietnam palo alto strain of plasmodium vivax. the median maximum parasite count was 280,000/microl. nine splenectomized monkeys with previous infection with plasmodium falciparum had median maximum parasite counts of 120,000/microl. splenectomized aotus nancymai monkeys supported infections at a lower level. transmission via the bites of anopheles dirus mosquitoes was ... | 2005 | 15986626 |
| aotus nancymaae as a potential model for the testing of anti-sporozoite and liver stage vaccines against plasmodium falciparum. | the santa lucia strain of plasmodium falciparum was transmitted to aotus lemurinus griseimembra, a. azarae boliviensis, a. vociferans, and a. nancymaae monkeys by bite and by intravenous inoculation of sporozoites dissected from anopheles freeborni, an. stephensi, an. gambiae, an. albimanus, and an. maculatus mosquitoes. the data obtained from these infections indicate that a. nancymaae can be considered a suitable host model when combined with the santa lucia strain of p. falciparum for the tes ... | 2006 | 16525100 |
| studies on sporozoite-induced and chronic infections with plasmodium fragile in macaca mulatta and new world monkeys. | plasmodium fragile continues to be investigated because of its biologic similarities to the human malaria parasite, plasmodium falciparum. two strains of p. fragile are available for study; one strain is able to infect mosquitoes, whereas the other strain is transmissible only by blood inoculation. the sri lanka strain of p. fragile was transmitted to macaca mulatta, macaca fascicularis, aotus lemurinus griseimembra, aotus nancymaae, aotus vociferans, and saimiri boliviensis monkeys via sporozoi ... | 2006 | 17152944 |
| adaptation of a multi-drug resistant strain of plasmodium falciparum from peru to aotus lemurinus griseimembra, a. nancymaae, and a. vociferans monkeys. | a strain of plasmodium falciparum from peru was adapted to splenectomized aotus nancymaae and aotus vociferans monkeys. the peru 134/cdc strain of p. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this peruvian strain of p. falciparum. | 2007 | 17690397 |
| the santa lucia strain of plasmodium falciparum in aotus monkeys. | the santa lucia strain of plasmodium falciparum was studied in 150 aotus lemurinus griseimembra, 30 a. azarae boliviensis, 103 a. nancymaae, and 121 a. vociferans monkeys. all four of these splenectomized hosts supported the production of gametocytes infective to anopheles freeborni mosquitoes. transmission through sporozoites from an. freeborni, an. stephensi, an. maculatus, and an. albimanus mosquitoes was successful to all four species of aotus on a total of 100 occasions with a median pre-pa ... | 2009 | 19346371 |
| antibody responses to a novel plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in aotus monkeys. | the block 2 region of the merozoite surface protein-1 (msp-1) of plasmodium falciparum has been identified as a target of protective immunity by a combination of seroepidemiology and parasite population genetics. immunogenicity studies in small animals and aotus monkeys were used to determine the efficacy of recombinant antigens derived from this region of msp-1 as a potential vaccine antigen. aotus lemurinus griseimembra monkeys were immunized three times with a recombinant antigen derived from ... | 2014 | 24421900 |