| a recently discovered pathogenic paramyxovirus, sosuga virus, is present in rousettus aegyptiacus fruit bats at multiple locations in uganda. | in august 2012, a wildlife biologist became ill immediately following a 6-wk field trip to collect bats and rodents in south sudan and uganda. after returning to the us, the biologist was admitted to the hospital with multiple symptoms including fever, malaise, headache, generalized myalgia and arthralgia, stiffness in the neck, and sore throat. soon after admission, the patient developed a maculopapular rash and oropharynx ulcerations. the patient remained hospitalized for 14 d. several suspect ... | 2015 | 25919464 |
| development of a reverse genetics system for sosuga virus allows rapid screening of antiviral compounds. | sosuga virus (sosv) is a recently discovered zoonotic paramyxovirus isolated from a single human case in 2012; it has been ecologically and epidemiologically associated with transmission by the egyptian rousette bat (rousettus aegyptiacus). bats have long been recognized as sources of novel zoonotic pathogens, including highly lethal paramyxoviruses like nipah virus (niv) and hendra virus (hev). the ability of sosv to cause severe human disease supports the need for studies on sosv pathogenesis ... | 2018 | 29522528 |
| experimental infection of egyptian rousette bats (rousettus aegyptiacus) with sosuga virus demonstrates potential transmission routes for a bat-borne human pathogenic paramyxovirus. | in august 2012, a wildlife biologist became severely ill after becoming infected with a novel paramyxovirus, termed sosuga virus. in the weeks prior to illness, the patient worked with multiple species of bats in south sudan and uganda, including egyptian rousette bats (erbs: rousettus aegyptiacus). a follow-up study of ugandan bats found multiple wild-caught erbs to test positive for sosv in liver and spleen. to determine the competency of these bats to act as a natural reservoir host for sosv ... | 2020 | 32119657 |
| antibody-mediated virus neutralization is not a universal mechanism of marburg, ebola, or sosuga virus clearance in egyptian rousette bats. | although bats are increasingly being recognized as natural reservoir hosts of emerging zoonotic viruses, little is known about how they control and clear virus infection in the absence of clinical disease. here, we test >50 convalescent sera from egyptian rousette bats (erbs) experimentally primed or prime-boosted with marburg virus, ebola virus, or sosuga virus for the presence of virus-specific neutralizing antibodies, using infectious reporter viruses. after serum neutralization testing, we c ... | 2019 | 30590775 |
| genomic features of humoral immunity support tolerance model in egyptian rousette bats. | bats asymptomatically harbor many viruses that can cause severe human diseases. the egyptian rousette bat (erb) is the only known reservoir for marburgviruses and sosuga virus, making it an exceptional animal model to study antiviral mechanisms in an asymptomatic host. with this goal in mind, we constructed and annotated the immunoglobulin heavy chain locus, finding an expansion on immunoglobulin variable genes associated with protective human antibodies to different viruses. we also annotated t ... | 2021 | 34010652 |