| metagenomic discovery and co-infection of diverse wobbly possum disease viruses and a novel hepacivirus in australian brushtail possums. | australian brushtail possums (trichosurus vulpecula) are an introduced pest species in new zealand, but native to australia where they are protected for biodiversity conservation. wobbly possum disease (wpd) is a fatal neurological disease of australian brushtail possums described in new zealand populations that has been associated with infection by the arterivirus (arteriviridae) wobbly possum disease virus (wpdv-nz). clinically, wpd-infected possums present with chronic meningoencephalitis, ch ... | 2019 | 33829126 |
| development of an indirect elisa for detection of antibody to wobbly possum disease virus in archival sera of australian brushtail possums (trichosurus vulpecula) in new zealand. | to develop an indirect elisa based on recombinant nucleocapsid (rn) protein of wobbly possum disease (wpd) virus for investigation of the presence of wpd virus in australian brushtail possums (trichosurus vulpecula) in new zealand. | 2018 | 29669478 |
| viral rna load and histological changes in tissues following experimental infection with an arterivirus of possums (wobbly possum disease virus). | tissues from australian brushtail possums (trichosurus vulpecula) that had been experimentally infected with wobbly possum disease (wpd) virus (wpdv) were examined to elucidate pathogenesis of wpdv infection. mononuclear inflammatory cell infiltrates were present in livers, kidneys, salivary glands and brains of wpd-affected possums. specific staining was detected by immunohistochemistry within macrophages in the livers and kidneys, and undefined cell types in the brains. the highest viral rna l ... | 2018 | 30014860 |
| serological evidence for the presence of wobbly possum disease virus in australia. | wobbly possum disease virus (wpdv) is an arterivirus that was originally identified in common brushtail possums (trichosurus vulpecula) in new zealand, where it causes severe neurological disease. in this study, serum samples (n = 188) from australian common brushtail, mountain brushtail (trichosurus cunninghami) and common ringtail (pseudocheirus peregrinus) possums were tested for antibodies to wpdv using elisa. antibodies to wpdv were detected in possums from all three species that were sampl ... | 2020 | 32750064 |