| pharmacology of n-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (sch 351591), a novel, orally active phosphodiesterase 4 inhibitor. | n-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (sch 351591) has been identified as a potent (ic(50) = 58 nm) and highly selective type 4 phosphodiesterase (pde4) inhibitor with oral bioactivity in several animal models of lung inflammation. n-(3,5-dichloro-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (sch 365351), the only significant in vivo metabolite, is also a potent and highly selective pde4 inhibitor (ic(50) = 20 nm). both s ... | 2002 | 12065709 |