diseases of the european wildcat (felis silvestris schreber, 1777) in great britain.the author describes an examination conducted in collaboration with the nature conservancy council of great britain into the status with regard to disease, conservation and genetics of the european wildcat (felis silvestris). feline leukaemia virus (felv) infection was detected by positive enzyme-linked immunosorbent assay in blood from 2 of 23 wildcats and was tested and confirmed by felv isolation in one of the two cats. this is the first time the virus has been clearly demonstrated in a free- ...19921339067
neutrophil survival factors (tnf-alpha, gm-csf, and g-csf) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions.feline infectious peritonitis (fip) is a feline coronavirus (fcov)-induced fatal disease of domestic and wild cats. the infiltration of neutrophils into granulomatous lesions is unusual for a viral disease, but it is a typical finding of fip. this study aimed to investigate the reason for the lesions containing neutrophils in cats with fip. neutrophils of cats with fip were cultured, and changes in the cell survival rate were assessed. in addition, the presence or absence of neutrophil survival ...200919343474
exposure to selected pathogens in to selected pathogens in geoffroy's cats and domestic carnivores from central argentina.wild carnivores share a high percentage of parasites and viruses with closely related domestic carnivores. because of increased overlap and potential contact with domestic species, we conducted a retrospective serosurvey for 11 common carnivore pathogens in 40 geoffroy's cats (leopardus geoffroyi) sampled between 2000 and 2008 within or near two protected areas in central argentina (lihué calel national park, la pampa, and campos del tuyú national park, buenos aires), as well as five domestic ca ...201223060491
x-ray structure and inhibition of the feline infectious peritonitis virus 3c-like protease: structural implications for drug design.feline infectious peritonitis (fip) is a deadly disease that effects both domestic and wild cats and is caused by a mutation in feline coronavirus (fcov) that allows the virus to replicate in macrophages. currently, there are no treatments or vaccines available for the treatment of fip even though it kills approximately 5% of cats in multi-cat households per year. in an effort to develop small molecule drugs targeting fip for the treatment of cats, we screened a small set of designed peptidomime ...201526592814
evaluation of protective efficacy of the synthetic peptide vaccine containing the t-helper 1 epitope with cpg oligodeoxynucleotide against feline infectious peritonitis virus infection in cats.feline infectious peritonitis (fip) is a feline coronavirus-induced fatal disease in domestic and wild cats. cellular immunity is considered to play an important role in the prevention of fip. thus, induction of the cellular immune response is essential in vaccines against fip virus (fipv) infection.201424458025
generation, characterization and therapeutic potential of anti-feline tnf-alpha mabs for feline infectious peritonitis.feline infectious peritonitis (fip) is a lethal infectious disease affecting domestic and wild cats. several reports suggested that tnf-alpha is related to the progression of fip. thus, the administration of a feline tnf-alpha-neutralizing antibody to cats with fip may reduce the disease progression. in this study, we have prepared nine monoclonal antibodies (mabs) that recognize feline tnf-alpha. all mabs neutralized recombinant tnf-alpha. the 50% inhibitory concentrations (ic50) of the mabs fo ...201324095161
effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo.feline infectious peritonitis (fip) is a feline coronavirus-induced fatal disease in domestic and wild cats. several studies have investigated potential treatments for fip. however, there have been no reports on agents that have exhibited a therapeutic effect. recently, chloroquine has been reported to antiviral effect. we investigated whether chloroquine can be used to treat fip in vitro and in vivo. it was demonstrated that chloroquine has inhibitory effect against the replication of fipv and ...201323648708
characterization of amino acid substitutions in feline coronavirus 3c-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor.feline infectious peritonitis (fip) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. we have previously reported the synthesis of potent coronavirus 3c-like protease (3clpro) inhibitors and the efficacy of a protease inhibitor, gc376, in client-owned cats with fip. in this study, we studied the effect of the amino acid changes in 3clpro of feline coronavirus from a feline patient who received antiviral treatment for prolonged duration. we generated rec ...201931585653
virological survey in free-ranging wildcats (felis silvestris) and feral domestic cats in determine the presence of viral pathogens in natural areas a survey was conducted on an opportunistic sample of fifty eight wild (felis silvestris silvestris) and feral cats (f. s. catus). the biological materials included serum, lung tissue extract and stool. feline leukemia virus p27 antigen was detected in 13/50 serum/lung tissue extract samples (26%), canine distemper virus antibodies were detected in 2/26 serum/lung tissue extract samples (7.7%), feline coronavirus rna was present in 6/2 ...201222424865
prevalence of seropositivity to pathogens in small carnivores in adjacent areas of lazovskii reserve.the prevalence of infectious diseases in wild and feral carnivores is poorly known in primorsky krai, where rare species such as the amur tiger and the far east leopard roam. in this study we evaluated the prevalence of seropositivity in feral (cats, dogs) and wild (raccoon dog, badger, american mink, far eastern wild cat) carnivores to various pathogens: distemper virus, parvovirus, feline immunodeficiency and feline leukemia virus, feline coronavirus, toxoplasma gondii, mycoplasma sp., and chl ...201232214774
a serological survey of common feline pathogens in free-living european wildcats (felis silvestris) in central spain.twenty-five serum samples of 22 free-living european wildcats (felis silvestris) captured from 1991 to 1993 in central spain were tested for evidence of exposure to seven feline pathogens. all the wildcats but one (95.4%) presented evidence of contact with at least one of the agents (mean = 2.2). contact with feline leukemia virus (felv) was detected in 81% of the wildcats (antibodies, 77%; antigen p27, 15%). antibodies to feline calicivirus (fcv, 80%), feline herpesvirus (fhv, 20%), feline parv ...200932214938
canine distemper virus may affect european wild cat populations in central spain.the main objective of this brief communication is to inform about the exposure to certain pathogens of interest for mesocarnivores in wildcats (felis silvestris silvestris) that inhabit a human-domestic-wild ecotone located in a natural park (serranía de cuenca, central spain). blood and mucosal swabs (nasal, conjunctival and rectal) samples were collected from nine alive animals to detect canine distemper virus (cdv), parvovirus (cpv/fpv), feline leukaemia virus (felv), feline coronavirus (fcov ...201932218716
antiviral activity of itraconazole against type i feline coronavirus infection.feline coronaviruses (fcovs) are the causative agents of severe systemic disease (feline infectious peritonitis: fip) in domestic and wild cats. fcovs have been classified into serotypes i and ii. type i fcov is the dominant serotype (approximately 70-90%) worldwide. therefore, it is necessary to provide antiviral agents for type i fcov infection. in this study, we demonstrated that itraconazole (icz), practically used for fungal infections in cats, inhibits the type i fcov infection. icz also e ...201930658691
pathogenesis of oral type i feline infectious peritonitis virus (fipv) infection: antibody-dependent enhancement infection of cats with type i fipv via the oral route.feline infectious peritonitis virus (fipv) causes a severe, immune-mediated disease called fip in domestic and wild cats. it is unclear whether fip transmits from cat to cat through the oral route of fipv infection, and the reason for this includes that fip is caused by oral inoculation with some fipv strains (e.g., type ii fipv wsu 79-1146), but is not caused by other fipv (e.g., type i fipv ku-2 strain: fipv-i ku-2). in this study, when cats passively immunized with anti-fipv-i ku-2 antibodies ...201931019150
parasite prevalence in free-ranging farm cats, felis silvestris animals tested were positive for feline leukemia virus antigen and chlamydia psittaci antibodies, but all were positive for antibodies to feline calicivirus (fcv), feline herpesvirus 1 (fhv1) and rotavirus. they had antibodies to feline parvovirus (96%), feline coronavirus (84% and cowpox virus (2%). antibody to feline immunodeficiency virus (fiv) was found in 53% of animals, which were less likely to be infected with haemobartonella felis, and had higher fhv antibody titres than cats without ...19968620914
a serologic survey of wild felids from central west saudi arabia.forty-five wildcats (felis silvestris), 17 sand cats (felis margarita), and 17 feral domestic cats were captured in central west saudi arabia, between may 1998 and april 2000, with the aim to assess their exposure to feline immunodeficiency virus/puma lentivirus (fiv/plv), feline leukaemia virus (felv), feline herpesvirus (fhv-1), feline calicivirus (fcv), feline coronavirus (fcov), and feline panleukopenia virus (fplv). serologic prevalence in wildcats, sand cats, and feral domestic cats were r ...200314567233
viral infections in free-living populations of the european wildcat.while the importance of viral infections is well studied in domestic cats, only limited information is available on their occurence and prevalence in the european wildcat (felis silvestris silvestris). the aim of this study was to determine the prevalence of antibodies to feline coronavirus (fcov), calicivirus (fcv), herpesvirus (fhv), parvovirus (fpv), immunodeficiency virus (fiv), leukemia virus (felv), and felv antigenemia in 51 european wildcat sera. samples were collected between 1996 and 1 ...199910574526
feline viruses in wildcats from scotland.few data are available on the prevalence of feline viruses in european wildcats (felis silvestris). previous surveys have indicated that wildcats may be infected with the common viruses of domestic cats, apart from feline immunodeficiency virus (fiv). in the present study, 50 wildcats trapped throughout scotland (uk) between august 1992 and january 1997 were tested for evidence of viral infection. all were negative for fiv by several serological or virological methods. by contrast, 10% of the ca ...199910073361
some viral and protozool diseases in the european wildcat (felis silvestris).ten european wildcats (felis silvestris) were examined at necropsy and an additional 23 were examined clinically for evidence of viral diseases in scotland. two plasma samples taken from live free-living wildcats showed positive elisa reactions to feline leukemia antigen. a feline leukemia virus of subgroup a was isolated from one of these samples, taken from a wildcat in north-western scotland. no antibodies to feline coronavirus or feline immunodeficiency virus were detected in any sample. thr ...19911758037
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