| prevalence and risk factors of gammaherpesvirus infection in domestic cats in central europe. | gammaherpesviruses (ghvs) are a large group of dsdna viruses that can infect humans and several animal species. the two human ghvs, epstein-barr virus and kaposi's sarcoma-associated herpesvirus are known for their oncogenic properties in individuals with immunodeficiency. recently, the first feline ghv, felis catus gammaherpesvirus 1 (fcaghv1) was discovered and frequently found in domestic cats in australia, singapore and the usa. fcaghv1 is more likely to be detected in cats co-infected with ... | 2015 | 26377918 |
| felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats. | felis catus gammaherpesvirus 1 (fcaghv1), recently discovered in the usa, was detected in domestic cats in australia (11.4%, 95% confidence interval 5.9-19.1, n=110) and singapore (9.6%, 95% confidence interval 5.9-14.6, n=176) using qpcr. fcaghv1 qpcr positive cats were 2.8 times more likely to be sick than healthy. risk factors for fcaghv1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (fiv) or feline leukaemia virus. f ... | 2014 | 25010275 |
| identification of felis catus gammaherpesvirus 1 in tsushima leopard cats (prionailurus bengalensis euptilurus) on tsushima island, japan. | felis catus gammaherpesvirus 1 (fcaghv1) is a widely endemic infection of domestic cats. current epidemiological data identify domestic cats as the sole natural host for fcaghv1. the tsushima leopard cat (tlc; prionailurus bengalensis euptilurus) is a critically endangered species that lives only on tsushima island, nagasaki, japan. nested pcr was used to test the blood or spleen of 89 tlcs for fcaghv1 dna; three (3.37%; 95% ci, 0.70⁻9.54) were positive. for tlc management purposes, we also scre ... | 2018 | 30029545 |
| detection of felis catus gammaherpesvirus 1 (fcaghv1) in peripheral blood b- and t-lymphocytes in asymptomatic, naturally-infected domestic cats. | the domestic cat is natural host to both feline immunodeficiency virus and felis catus gammaherpesvirus 1 (fcaghv1). comparative data suggest that these agents might act as synergistic copathogens in feline aids-related lymphoma. to identify leucocyte subsets harbouring gammaherpesvirus dna, whole blood from 5 healthy, fcaghv1-infected cats was labelled with monoclonal antibodies to feline cd21, cd4, cd8 and cd14 for 4-way fluorescence-activated cell sorting. fcaghv1gb qpcr was performed on dna ... | 2016 | 27497183 |
| prevalence and risk factors for felis catus gammaherpesvirus 1 detection in domestic cats in italy. | felis catus gammaherpesvirus 1 (fcaghv1), a novel gammaherpesvirus of domestic cats identified in 2014, has been detected in different countries demonstrating a worldwide distribution. the aim of this study was to establish the prevalence of fcaghv1 in italy using a molecular epidemiological approach. fcaghv1 dna was detected with virus-specific real-time pcr in ≃1% of 2659 feline blood samples tested. analysis of risk factors showed that being male and coinfection with feline immunodeficiency v ... | 2019 | 31648722 |
| transcriptome analysis and in situ hybridization for fcaghv1 in feline lymphoma. | lymphoma is one of the most common malignancies in domestic cats. the lymphomagenic potential of felis catus gammaherpesvirus 1 (fcaghv1), a common infection in domestic cats, is unknown. in other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed during latency. we analysed tumour rna, from diffuse large b-cell lymphomas (dlbcl) appearing in cats coinfected with fcaghv1 and feline immunodeficiency virus (fiv) (n = 10), by high ... | 2018 | 30200210 |
| first complete genome sequence of felis catus gammaherpesvirus 1. | we sequenced the complete genome of felis catus gammaherpesvirus 1 (fcaghv1) from lymph node dna of an infected cat. the genome includes a 121,556-nucleotide unique region with 87 predicted open reading frames (61 gammaherpesvirus conserved and 26 unique) flanked by multiple copies of a 966-nucleotide terminal repeat. | 2015 | 26543105 |
| high prevalence of felis catus gammaherpesvirus 1 infection in haemoplasma-infected cats supports co-transmission. | felis catus gammaherpesvirus 1 (fcaghv1), a potential feline pathogen, has been identified in domestic cats from usa, asia-pacific and central europe. transmission of fcaghv1 during territorial encounters, a route not typical for gammaherpesviruses, is suggested by risk factor analyses from some regions. the aim of this study was to investigate the relationship between fcaghv1 detection and risk factors, including haemoplasma co-infections, among uk cats to better understand transmission and glo ... | 2016 | 27387737 |
| domestic cats seropositive for felis catus gammaherpesvirus 1 are often qpcr negative. | felis catus gammaherpesvirus 1 (fcaghv1) is a newly described virus that infects domestic cats. to identify fcaghv1 antigens, we developed an immunofluorescent antibody assay by expressing fcaghv1 open reading frames (orfs) in feline cells and incubating fixed cells with sera from fcaghv1-positive cats. of the seven orfs tested, orf52 and orf38 had the strongest, most consistent antibody responses. we used recombinant orf52 and orf38 proteins to develop two fcaghv1 elisas. these assays were used ... | 2016 | 27540873 |
| molecular diagnosis of felis catus gammaherpesvirus 1 (fcaghv1) infection in cats of known retrovirus status with and without lymphoma. | the pathogenicity offelis catusgammaherpesvirus 1 (fcaghv1), a common infection of domestic cats, is unknown. to explore an association between fcaghv1 detection and feline lymphoma, a retrospective, cross-sectional, disease-association study was conducted. the infection status of all cats for feline immunodeficiency virus and feline leukaemia virus was determined. neither a molecular diagnosis of fcaghv1 nor whole-blood fcaghv1 load was related to outcome in 122 lymphoma cases compared with 71 ... | 2018 | 29538321 |
| felis catus gammaherpesvirus 1 dnaemia in whole blood from therapeutically immunosuppressed or retrovirus-infected cats. | gammaherpesviruses are major co-pathogens of human immunodeficiency virus (hiv) infection, making the interactions between feline immunodeficiency virus (fiv) andfelis catusgammaherpesvirus 1 (fcaghv1) pertinent to both human and veterinary medical research. fiv-infected cats are at increased risk of fcaghv1 dnaemia and consistently harbor higher fcaghv1 loads than fiv-uninfected cats. whether immune deficiencies unrelated to fiv are associated with similar risks is unknown. using whole blood fc ... | 2017 | 29056675 |