| leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors. | sand fly species able to support the survival of the protozoan parasite leishmania have been classified as permissive or specific, based upon their ability to support a wide or limited range of strains and/or species. studies of a limited number of fly/parasite species combinations have implicated parasite surface molecules in this process and here we provide further evidence in support of this proposal. we investigated the role of lipophosphoglycan (lpg) and other phosphoglycans (pgs) in sand f ... | 2010 | 20084096 |
| visualisation of leishmania donovani fluorescent hybrids during early stage development in the sand fly vector. | the leishmania protozoan parasites cause devastating human diseases. leishmania have been considered to replicate clonally, without genetic exchange. however, an accumulation of evidence indicates that there are inter-specific and intra-specific hybrids among natural populations. the first and so far only experimental proof of genetic exchange was obtained in 2009 when double drug resistant leishmania major hybrids were produced by co-infecting sand flies with two strains carrying different drug ... | 2011 | 21637755 |
| the role of surface glycoconjugates in leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies. | binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the leishmania life cycle in the vector. among leishmania surface molecules putatively involved in attachment to the sand fly midgut, two gpi-anchored molecules are the most prominent: lipophosphoglycan (lpg) and promastigote surface protease gp63. in this work, we examined midgut attachment of leishmania lines mutated in gpi-anchored molecules and compared results from 2 different techniques: in vivo ... | 2013 | 23611086 |