| leishmania parasites (kinetoplastida: trypanosomatidae) reversibly inhibit visceral muscle contractions in hemimetabolous and holometabolous insects. | female sand flies can acquire protozoan parasites in the genus leishmania when feeding on an infected vertebrate host. the parasites complete a complex growth cycle in the sand fly gut until they are transmitted by bite to another host. recently, a myoinhibitory peptide was isolated from leishmania major promastigotes. this peptide caused significant gut distension and reversible, dose-dependent inhibition of spontaneous hindgut contractions in the enzootic sand fly vector, phlebotomus papatasi. ... | 2004 | 15579321 |
| stages in the identification of phlebotomine sandflies as vectors of leishmaniases and other tropical diseases. | the first time the term phlebotomine sandfly was used, was by an italian naturalist, philippo bonanni, in 1691. the first description though was made by another italian naturalist, scopoli, under the name bibio papatasi. the name of the genus, phlebotomus, was not given until 1840 by rondani and berté. the first description of an american phlebotomine sandfly was made by coquillett, in 1907. the discovery of the three first sandflies in brazil is the work of lutz and neiva, in 1912. from this da ... | 2005 | 16866034 |
| lutzomyia longipalpis saliva or salivary protein ljm19 protects against leishmania braziliensis and the saliva of its vector, lutzomyia intermedia. | leishmania transmission occurs in the presence of insect saliva. immunity to phlebotomus papatasi or lutzomyia longipalpis saliva or salivary components confers protection against an infection by leishmania in the presence of the homologous saliva. however, immunization with lutzomyia intermedia saliva did not protect mice against leishmania braziliensis plus lu. intermedia saliva. in the present study, we have studied whether the immunization with lu. longipalpis saliva or a dna plasmid coding ... | 2011 | 21655303 |
| functional transcriptomics of wild-caught lutzomyia intermedia salivary glands: identification of a protective salivary protein against leishmania braziliensis infection. | leishmania parasites are transmitted in the presence of sand fly saliva. together with the parasite, the sand fly injects salivary components that change the environment at the feeding site. mice immunized with phlebotomus papatasi salivary gland (sg) homogenate are protected against leishmania major infection, while immunity to lutzomyia intermedia sg homogenate exacerbated experimental leishmania braziliensis infection. in humans, antibodies to lu. intermedia saliva are associated with risk of ... | 2013 | 23717705 |
| the flagellar protein flag1/smp1 is a candidate for leishmania-sand fly interaction. | leishmaniasis is a serious problem that affects mostly poor countries. various species of leishmania are the agents of the disease, which take different clinical manifestations. the parasite is transmitted by sandflies, predominantly from the phlebotomus genus in the old world and lutzomyia in the new world. during development in the gut, leishmania must survive various challenges, which include avoiding being expelled with blood remnants after digestion. it is believed that attachment to the gu ... | 0 | 25793476 |