| nonstructural protein 3 of bluetongue virus assists virus release by recruiting escrt-i protein tsg101. | the release of bluetongue virus (btv) and other members of the orbivirus genus from infected host cells occurs predominantly by cell lysis, and in some cases, by budding from the plasma membrane. two nonstructural proteins, ns3 and ns3a, have been implicated in this process. here we show that both proteins bind to human tsg101 and its ortholog from drosophila melanogaster with similar strengths in vitro. this interaction is mediated by a conserved psap motif in ns3 and appears to play a role in ... | 2006 | 16352570 |
| drosophila melanogaster as a model organism for bluetongue virus replication and tropism. | bluetongue virus (btv) is the etiological agent of bluetongue (bt), a hemorrhagic disease of ruminants that can cause high levels of morbidity and mortality. btv is an arbovirus transmitted between its ruminant hosts by culicoides biting midges (diptera: ceratopogonidae). recently, europe has experienced some of the largest bt outbreaks ever recorded, including areas with no known history of the disease, leading to unprecedented economic and animal welfare issues. the current lack of genomic res ... | 2012 | 22674991 |