prion disease detection, pmca kinetics, and igg in urine from sheep naturally/experimentally infected with scrapie and deer with preclinical/clinical chronic wasting disease. | prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. low levels of infectious agent and limited, infrequent success of disease transmissibility and prp(sc) detection have been reported with urine from experimentally infected clinical cervids and rodents. we report the detection of prion disease-associated seeding activity (pasa) in urine from naturally and orally infected sheep with clinical scrapie agent and orally infected preclinical ... | 2011 | 21715495 |