in vitro prion protein conversion suggests risk of bighorn sheep (ovis canadensis) to transmissible spongiform encephalopathies.transmissible spongiform encephalopathies (tses) affect both domestic sheep (scrapie) and captive and free-ranging cervids (chronic wasting disease; cwd). the geographical range of bighorn sheep (ovis canadensis; bhs) overlaps with states or provinces that have contained scrapie-positive sheep or goats and areas with present epizootics of cwd in cervids. no tses have been documented in bhs, but the susceptibility of this species to tses remains unknown.201323938169
prion disease detection, pmca kinetics, and igg in urine from sheep naturally/experimentally infected with scrapie and deer with preclinical/clinical chronic wasting disease.prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. low levels of infectious agent and limited, infrequent success of disease transmissibility and prp(sc) detection have been reported with urine from experimentally infected clinical cervids and rodents. we report the detection of prion disease-associated seeding activity (pasa) in urine from naturally and orally infected sheep with clinical scrapie agent and orally infected preclinical ...201121715495
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