topographic distribution of scrapie amyloid-immunoreactive plaques in chronic wasting disease in captive mule deer (odocoileus hemionus hemionus).chronic wasting disease (cwd), a progressive neurological disorder of captive mule deer, black-tailed deer, hybrids of mule deer and white-tailed deer and rocky mountain elk, is characterized neuropathologically by widespread spongiform change of the neuropil, intracytoplasmic vacuolation in neuronal perikarya and astrocytic hypertrophy and hyperplasia. we report the topographic distribution of amyloid plaques reactive to antibodies prepared against scrapie amyloid in cwd-affected captive mule d ...19911713390
chronic wasting disease of captive mule deer: a spongiform the past 12 years (1967-79) a syndrome we identify as chronic wasting disease has been observed in 53 mule deer (odocoileus hemionus hemionus) and one black-tailed deer (odocoileus hemionus columbianus) held in captivity in several wildlife facilities in colorado and more recently in wyoming. clinical signs were seen in adult deer and included behavioral alterations, progressive weight loss and death in 2 weeks to 8 months. gross necropsy findings included emaciation and excess rumen fluid ad ...19807373730
retrospective investigation of chronic wasting disease of cervids at the toronto zoo, 1973-2003.the occurrence of chronic wasting disease (cwd) at the toronto zoo was investigated retrospectively, based on an examination of management, animal health, and postmortem records, and immunohistochemical studies. records of animal movements, clinical signs, and postmortem findings were examined for all cervids 1973-2003. all available samples of fixed, wax-embedded lymphoid or central nervous system tissue from cervids that died at the toronto zoo from 1973 to 2003, > 12 months of age, were teste ...200617217088
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