historical overview of prion diseases: a view from afar.the transmissible spongiform encephalopathies (tses), or prion diseases, are a group of neurodegenerative disorders which include kuru, creutzfeldt-jakob disease (cjd), gerstmann-sträussler-scheinker (gss) syndrome, and fatal familial insomnia in men, natural scrapie in sheep, goats and mufflons, transmissible mink encephalopathy in ranch-reared mink, chronic wasting disease of mule deer and elk, bovine spongiform encephalopathy or "mad cow disease" and its analogues in several exotic species of ...201222505359
experimental second passage of chronic wasting disease (cwd(mule deer)) agent to compare clinicopathological findings in first and second passage chronic wasting disease (cwd(mule deer)) in cattle, six calves were inoculated intracerebrally with brain tissue derived from a first-passage cwd-affected calf in an earlier experiment. two uninoculated calves served as controls. the inoculated animals began to lose both appetite and weight 10-12 months later, and five subsequently developed clinical signs of central nervous system (cns) abnormality. by 16.5 months, all cattle h ...200616423572
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