Publications

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characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the luangwa valley, zambia.animal and human trypanosomiasis are constraints to both animal and human health in sub-saharan africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems. the luangwa valley in zambia supports high densities of tsetse flies (glossina species) and is recognised as an historical sleeping sickness focus. the objective of this study was to characterise the nature of the reservoir community for trypanosomiasis in the absence of influence from ...201121713019
the influence of host blood on infection rates in glossina morsitans sspp. infected with trypanosoma congolense, t. brucei and t. simiae.trypanosoma congolense, t. brucei and t. simiae isolated from wild-caught glossina pallidipes were fed to laboratory-reared g. morsitans centralis and g.m. morsitans to determine the effect of host blood at the time of the infective feed on infection rates. bloodstream forms of trypanosomes were membrane-fed to flies either neat, or mixed with blood from cows, goats, pigs, buffalo, eland, waterbuck and oryx. the use of different bloods for the infective feed resulted in differences in infection ...19938355996
relationships between protease activity, host blood and infection rates in glossina morsitans sspp. infected with trypanosoma congolense, t. brucei and t. simiae.midgut protease activity in glossina morsitans centralis and g.m. morsitans, at 48 h post bloodmeal averaged 1.8iu of trypsin-like activity. these two tsetse subspecies differ in their susceptibility to trypanosome infection. except for low levels in flies fed on waterbuck blood (0.7 iu), activity did not differ in flies fed a variety of host bloods (goat, pig, cow, buffalo, eland) and trypanosome species (trypanosoma congolense, t. brucei, t. simiae). protease activity was also not correlated w ...19948161844
infection rates in glossina morsitans morsitans fed on waterbuck and boran cattle infected with trypanosoma congolense.teneral glossina morsitans morsitans were fed on waterbuck (kobus defassa) and boran cattle (bos indicus) infected experimentally with trypanosoma congolense clone il2895. infection rates in tsetse varied from 9 to 31% when fed on cattle, and from 2 to 59% when fed on waterbuck. in waterbuck, infections were often detected through the development of parasites in tsetse at times when parasitaemia could not be detected through microscopic examination of blood. male and female, and 1- and 2-day-old ...19911685299
pathogenicity of tsetse-transmitted trypanosoma congolense for waterbuck (kobus defassa) and boran cattle (bos indicus).five waterbuck (kobus defassa) and four boran cattle (bos indicus) were infected with trypanosoma congolense il2895 using glossina morsitans morsitans. at the same time, two waterbuck and two cattle were inoculated intravenously with bloodstream forms. with both methods of challenge, cattle had short prepatent periods followed by a continuous high parasitaemia. all cattle became severely anaemic and had to be treated with trypanocidal drugs to prevent death. in contrast, tsetse and intravenous c ...19911685298
study on the sequential tsetse-transmitted trypanosoma congolense, t. brucei brucei and t. vivax infections to african buffalo, eland, waterbuck, n'dama and boran cattle.susceptibility of african buffalo, eland, waterbuck, n'dama and boran cattle to sequential glossina morsitans centralis-transmitted infections of trypanosoma congolense, t. brucei brucei and t. vivax was compared, and their possible role as reservoirs of these parasites for g. moristans centralis, g. pallidipes, g. austeni, g. brevipalpis and g. longipennis determined. the buffalo, eland, waterbuck and n'dama controlled t. congolense parasitaemias and were able to prevent anaemia. by contrast, o ...19999950344
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