| the pathogenesis of foot-and-mouth disease ii: viral pathways in swine, small ruminants, and wildlife; myotropism, chronic syndromes, and molecular virus-host interactions. | investigation into the pathogenesis of foot-and-mouth disease (fmd) has focused on the study of the disease in cattle with less emphasis on pigs, small ruminants and wildlife. 'atypical' fmd-associated syndromes such as myocarditis, reproductive losses and chronic heat intolerance have also received little attention. yet, all of these manifestations of fmd are reflections of distinct pathogenesis events. for example, naturally occurring porcinophilic strains and unique virus-host combinations th ... | 2011 | 21672184 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| the pathogenesis and diagnosis of foot-and-mouth disease. | the pathogenesis of foot-and-mouth disease (fmd) is reviewed, taking account of knowledge gained from field and experimental studies and embracing investigations at the level of the virus, the cell, the organ, the whole animal and the herd or flock. the review also addresses the immune response and the carrier state in fmd. progress made in understanding the pathogenesis of the disease is highlighted in relation to developments in diagnosis and methods of control. | 2003 | 12859905 |