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investigation of the prion protein gene (prnp) polymorphisms in anatolian, murrah, and crossbred water buffaloes (bubalus bubalis).bovine spongiform encephalopathy (bse) of the cattle is the outstanding disease among other transmissible spongiform encephalopathy (tses). it can be transmitted from the cattle to a human and causes a new variant of the creutzfeldt-jakob disease (cjd). it is known that prion protein coding gene (prnp) plays a major role in the tse susceptibility or resistance in some species. recent researches demonstrated that the insertion (in) and deletion (del) polymorphisms within promoter and intron 1 reg ...201727822596
detection of prion gene promoter and intron1 indel polymorphisms in anatolian water buffalo (bubalus bubalis).bovine spongiform encephalopathy (bse) is a fatal disease caused by miss folded prion protein. studies in the cattle, comparing genetic data from bse diseased and healthy animals have shown that indel polymorphisms in the promoter and intron 1 of prnp gene were associated with disease susceptibility. several studies were conducted to find out allele and genotypic frequencies of indel polymorphisms in promoter and intron 1 of the cattle prnp gene. unlike domestic cattle and bison, no indel polymo ...200919912420
fixed differences in the 3'utr of buffalo prnp gene provide binding sites for mirnas post-transcriptional regulation.bovine spongiform encephalopathy, a member of transmissible spongiform encephalopathies, has not been reported in buffaloes, bubalus bubalis. prion protein (prp), encoded by the prion protein gene (prnp), is fundamental in the pathogenesis of transmissible spongiform encephalopathies. we previously showed that buffaloes express more prp proteins but lower prnp mrna than cattle in several pivotal tissues like the obex. therefore, we sought to establish whether genetic variability in prnp 3'utr, m ...201728545018
the prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo.prion protein, encoded by the prion protein gene (prnp), plays a crucial role in the pathogenesis of transmissible spongiform encephalopathies (tses). several polymorphisms within the prnp are known to be associated with influencing bovine spongiform encephalopathy (bse) susceptibility in cattle, namely two insertion/deletion (indel) polymorphisms (a 23-bp indel in the putative promoter and a 12-bp indel in intron 1), the number of octapeptide repeats (octarepeats) present in coding sequence (cd ...201526319996
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