spongiform encephalopathy in a miniature zebu.the first case of spongiform encephalopathy in a zebu (bos indicus) was identified in a zoo in switzerland. although histopathologic and immunohistochemical analyses of the central nervous system indicated a diagnosis of bovine spongiform encephalopathy (bse), molecular typing showed some features different from those of bse in cattle (b. taurus).200617326950
biochemical typing of pathological prion protein in aging cattle with bse.the broad enforcement of active surveillance for bovine spongiform encephalopathy (bse) in 2000 led to the discovery of previously unnoticed, atypical bse phenotypes in aged cattle that differed from classical bse (c-type) in biochemical properties of the pathological prion protein. depending on the molecular mass and the degree of glycosylation of its proteinase k resistant core fragment (prpres), mainly determined in samples derived from the medulla oblongata, these atypical cases are currentl ...200919470160
genetic variability of the coding region for the prion protein gene (prnp) in gayal (bos frontalis).the gayal (bos frontalis) is a rare semi-wild bovid species in which bovine spongiform encephalopathy (bse) has not been reported. polymorphisms of the prion protein gene (prnp) have been correlated significantly with resistance to bse. in this study, the coding region of prnp was cloned and characterized in samples from 125 gayal. a total of ten single nucleotide polymorphisms (snps), including six silent mutations (c60t, g75a, a108t, g126a, c357t and c678t) and four mis-sense mutations (c8a, g ...201121633886
frequencies of polymorphisms associated with bse resistance differ significantly between bos taurus, bos indicus, and composite cattle.transmissible spongiform encephalopathies (tses) are neurodegenerative diseases that affect several mammalian species. at least three factors related to the host prion protein are known to modulate susceptibility or resistance to a tse: amino acid sequence, atypical number of octapeptide repeats, and expression level. these factors have been extensively studied in breeds of bos taurus cattle in relation to classical bovine spongiform encephalopathy (bse). however, little is currently known about ...200818808703
the prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo.prion protein, encoded by the prion protein gene (prnp), plays a crucial role in the pathogenesis of transmissible spongiform encephalopathies (tses). several polymorphisms within the prnp are known to be associated with influencing bovine spongiform encephalopathy (bse) susceptibility in cattle, namely two insertion/deletion (indel) polymorphisms (a 23-bp indel in the putative promoter and a 12-bp indel in intron 1), the number of octapeptide repeats (octarepeats) present in coding sequence (cd ...201526319996
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