| development and evaluation of a diagnostic cytokine-release assay for mycobacterium suricattae infection in meerkats (suricata suricatta). | sensitive diagnostic tools are necessary for the detection of mycobacterium suricattae infection in meerkats (suricata suricatta) in order to more clearly understand the epidemiology of tuberculosis and the ecological consequences of the disease in this species. we therefore aimed to develop a cytokine release assay to measure antigen-specific cell-mediated immune responses of meerkats. | 2017 | 28052763 |
| social and environmental factors affect tuberculosis related mortality in wild meerkats. | tuberculosis (tb) is an important and widespread disease of wildlife, livestock and humans world-wide, but long-term empirical datasets describing this condition are rare. a population of meerkats (suricata suricatta) in south africa's kalahari desert have been diagnosed with mycobacterium suricattae, a novel strain of tb, causing fatal disease in this group-living species. this study aimed to find characteristics associated with clinical tb in meerkats. these characteristics could subsequently ... | 2017 | 28186336 |
| animal-adapted members of the <i>mycobacterium tuberculosis</i> complex endemic to the southern african subregion. | members of the mycobacterium tuberculosis complex (mtc) cause tuberculosis (tb) in both animals and humans. in this article, three animal-adapted mtc strains that are endemic to the southern african subregion - that is, mycobacterium suricattae, mycobacterium mungi, and the dassie bacillus - are reviewed with a focus on clinical and pathological presentations, geographic distribution, genotyping methods, diagnostic tools and evolution. moreover, factors influencing the transmission and establish ... | 2016 | 27796109 |
| whole genome sequence analysis of mycobacterium suricattae. | tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the mycobacterium tuberculosis complex (mtbc). a recently described member, mycobacterium suricattae, causes tuberculosis in meerkats (suricata suricatta) in southern africa and preliminary genetic analysis showed this organism to be closely related to an mtbc pathogen of rock hyraxes (procavia capensis), the dassie bacillus. here we make use of whole genome sequencing to describe the evolution of th ... | 2015 | 26542221 |
| animal-adapted members of the mycobacterium tuberculosis complex endemic to the southern african subregion. | members of the mycobacterium tuberculosis complex (mtc) cause tuberculosis (tb) in both animals and humans. in this article, three animal-adapted mtc strains that are endemic to the southern african subregion - that is, mycobacterium suricattae, mycobacterium mungi, and the dassie bacillus - are reviewed with a focus on clinical and pathological presentations, geographic distribution, genotyping methods, diagnostic tools and evolution. moreover, factors influencing the transmission and establish ... | 2016 | 27246904 |
| novel cause of tuberculosis in meerkats, south africa. | the organism that causes tuberculosis in meerkats (suricata suricatta) has been poorly characterized. our genetic analysis showed it to be a novel member of the mycobacterium tuberculosis complex and closely related to the dassie bacillus. we have named this epidemiologically and genetically unique strain m. suricattae. | 2013 | 24274183 |