| analysis of the complete genome of the first irkut virus isolate from china: comparison across the lyssavirus genus. | the genome of irkut virus, isolate irkv-thchina12, the first non-rabies lyssavirus from china (of bat origin), has been completely sequenced. in general, coding and non-coding regions of this viral genome are similar to those of other lyssaviruses. however, alignment of the deduced amino acid sequences of the structural proteins of irkv-thchina12 with those of other lyssavirus representatives revealed significant variability between viral species. the nucleoprotein and matrix protein were found ... | 2013 | 23872529 |
| antigenic characterisation of lyssaviruses in south africa. | there are at least six lyssavirus species that have been isolated in africa, which include classical rabies virus, lagos bat virus, mokola virus, duvenhage virus, shimoni bat virus and ikoma lyssavirus. in this retrospective study, an analysis of the antigenic reactivity patterns of lyssaviruses in south africa against a panel of 15 anti-nucleoprotein monoclonal antibodies was undertaken. a total of 624 brain specimens, collected between 2005 and 2009, confirmed as containing lyssavirus antigen ... | 2014 | 25685866 |
| comparison of pathogenic domains of rabies and african rabies-related lyssaviruses and pathogenicity observed in mice. | several lyssavirus species occur in africa (rabies virus, lagos bat virus, mokola virus, duvenhage virus, shimoni bat virus and ikoma lyssavirus), displaying a high sequence diversity between isolates belonging to the same species. there is limited information about comparative pathogenesis of these african lyssaviruses and this precludes authoritative opinion on the potential public and veterinary health impact. in this study, an analysis of representative african lyssaviruses attempted to corr ... | 2013 | 23718883 |
| antigenic and genetic characterization of a divergent african virus, ikoma lyssavirus. | in 2009, a novel lyssavirus (subsequently named ikoma lyssavirus, ikov) was detected in the brain of an african civet (civettictis civetta) with clinical rabies in the serengeti national park of tanzania. the degree of nucleotide divergence between the genome of ikov and those of other lyssaviruses predicted antigenic distinction from, and lack of protection provided by, available rabies vaccines. in addition, the index case was considered likely to be an incidental spillover event, and therefor ... | 2014 | 24496827 |
| novel lyssavirus in bat, spain. | a new tentative lyssavirus, lleida bat lyssavirus, was found in a bent-winged bat (miniopterus schreibersii) in spain. it does not belong to phylogroups i or ii, and it seems to be more closely related to the west causasian bat virus, and especially to the ikoma lyssavirus. | 2013 | 23648051 |
| complete genome sequence of ikoma lyssavirus. | lyssaviruses (family rhabdoviridae) constitute one of the most important groups of viral zoonoses globally. all lyssaviruses cause the disease rabies, an acute progressive encephalitis for which, once symptoms occur, there is no effective cure. currently available vaccines are highly protective against the predominantly circulating lyssavirus species. using next-generation sequencing technologies, we have obtained the whole-genome sequence for a novel lyssavirus, ikoma lyssavirus (ikov), isolate ... | 2012 | 22923801 |
| ikoma lyssavirus, highly divergent novel lyssavirus in an african civet. | evidence in support of a novel lyssavirus was obtained from brain samples of an african civet in tanzania. results of phylogenetic analysis of nucleoprotein gene sequences from representative lyssavirus species and this novel lyssavirus provided strong empirical evidence that this is a new lyssavirus species, designated ikoma lyssavirus. | 2012 | 22469151 |