| intratibial moloney sarcoma virus-induced osteosarcoma in the rat: tumor incidence and pathologic evaluation. | osteosarcomas were induced in approximately 80% of young new zealand black rats by the intratibial inoculation of moloney murine sarcoma virus from day 1 to day 5 after birth. the neoplasms were composed of a spectrum of well-differentiated to poorly differentiated osteoblasts, osteocytes, and osteoclasts. budding of c-type viral particles was associated with tumor induction. compared to rats inoculated on day 1 after birth, rats inoculated at 4 days of age developed consistently more osteoproli ... | 1977 | 264594 |