| experimental infection and horizontal transmission of modoc virus in deer mice (peromyscus maniculatus). | deer mice (peromyscus maniculatus) were inoculated with a sublethal dose of a field strain of modoc virus to determine patterns of viral persistence, shedding, and transmission. blood, serum, urine, fecal, and oral swab samples were collected at selected intervals until 63 days postinoculation (pi) after which lung, liver, spleen, kidney, and salivary glands were explanted. viral assays were conducted by intracranial inoculations of suckling mice and antibody titers were determined by the micro- ... | 1987 | 3035240 |
| modoc viral infections in the deer mouse peromyscus maniculatus. | the pathogenesis of modoc virus and its mechanism of transmission were investigated in peromyscus maniculatus gambeli (deer mouse) as a model to understand the natural history of this virus. animals were readily infected by the intranasal or subcutaneous route of inoculation. virus could be detected by direct isolation techniques in many organs and body fluids during the first 7 to 9 days after intranasal inoculation. increases in viral titers were detectable first in lungs and then the spleen, ... | 1974 | 4215763 |
| antigenic relationships of flaviviruses with undetermined arthropod-borne status. | in contrast to most of the arthropod-borne flaviviruses, the flaviviruses with undetermined arthropod-borne status are probably disseminated only by direct contact with excreta (saliva, urine, feces, etc.); however, as yet undescribed arthropod transmission cycles may be found for some of them. twenty-two of these flaviviruses, including prototype and recently isolated strains, were compared. biologic properties were defined by infectivity titrations in suckling mice and vero, llc-mk2, and prima ... | 1982 | 6293325 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |